ID   GNL3_XENTR              Reviewed;         548 AA.
AC   Q6P4W5;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Guanine nucleotide-binding protein-like 3;
DE   AltName: Full=Nucleostemin-like protein;
GN   Name=gnl3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in regulating cellular proliferation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q811S9}. Nucleus,
CC       nucleolus {ECO:0000250|UniProtKB:Q811S9}. Note=Shuttles between the
CC       nucleus and nucleolus. {ECO:0000250|UniProtKB:Q811S9}.
CC   -!- DOMAIN: In contrast to other GTP-binding proteins, this family is
CC       characterized by a circular permutation of the GTPase motifs described
CC       by a G4-G1-G3 pattern.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01058}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH63220.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC063220; AAH63220.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001263611.1; NM_001276682.1.
DR   AlphaFoldDB; Q6P4W5; -.
DR   SMR; Q6P4W5; -.
DR   GeneID; 394765; -.
DR   KEGG; xtr:394765; -.
DR   CTD; 26354; -.
DR   Xenbase; XB-GENE-6456133; gnl3.
DR   InParanoid; Q6P4W5; -.
DR   OrthoDB; 1210675at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013669; Expressed in 4-cell stage embryo and 14 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
DR   Gene3D; 1.10.1580.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR014813; Gnl3_N_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR023179; GTP-bd_ortho_bundle_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF08701; GN3L_Grn1; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; GTP-binding; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..548
FT                   /note="Guanine nucleotide-binding protein-like 3"
FT                   /id="PRO_0000122449"
FT   DOMAIN          125..305
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
FT   REGION          1..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          58..114
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..40
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..499
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..519
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         172..175
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         256..263
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   BINDING         298..301
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   548 AA;  61115 MW;  4EDD9BD7583F77FC CRC64;
     MKRPKLKKGS KRLSCHKRYK IQKKVREHNR KARKEAKKSG TRKQKKEISV PNNAPFKAEI
     LQEAQRRRQQ EEELKQNRKL ERQKEVAKRR KLDEKKKKNS EKREKRDNKK NKGTKAAESA
     EVVSCRHVNK VLEQSDVVLE VLDARDPLGS RCAQAEEAVL KSPNKRLLLL LNKADLVPRD
     VLEKWLQVLT AELPTVPFRC LPQAPSKSPG KKHKVPNTAD LCTENRCPGG QVLLRILHSL
     CPSQSDAIKV GVIGFANVGK SSVINSLKQS HVCNVGPTKG TTRVLQEVRL DPQIRMLDSP
     ALVVSPQNAP LAVMLRSVSD CNVDVLAAVS AILKHCSKQE LMLHYTLPDY RNSLECVTLL
     AQRRGLLKKG GVPDTEAAGR LLFNDWMGVR MKYYCQPPDS PGVQPHITKE VTAAMSSGIC
     SEQLAQDNAS TLKALKCPSP ANLVVFTSVG PTGAIMDERQ LVEPEPIEEE LEANDGEEDV
     EEEHEGSEEE EDEEVEQEVV SAKEQEVVSA KEQEVVSAKE QDSKSAGPSV SFDQAQEDDA
     YDFNTDFV