GNRHR_BOVIN
ID GNRHR_BOVIN Reviewed; 328 AA.
AC P32236;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Gonadotropin-releasing hormone receptor;
DE Short=GnRH receptor;
DE Short=GnRH-R;
GN Name=GNRHR;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8306635; DOI=10.1016/0739-7240(93)90037-c;
RA Kakar S.S., Rahe C.H., Neill J.D.;
RT "Molecular cloning, sequencing, and characterizing the bovine receptor for
RT gonadotropin releasing hormone (GnRH).";
RL Domest. Anim. Endocrinol. 10:335-342(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74.
RA Nelson S.E., Quirk C.E., Clay C.M.;
RT "Bovine gonadotropin releasing hormone receptor gene.";
RL Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that
CC mediates the action of GnRH to stimulate the secretion of the
CC gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating
CC hormone (FSH). This receptor mediates its action by association with G-
CC proteins that activate a phosphatidylinositol-calcium second messenger
CC system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U00934; AAC48857.1; -; mRNA.
DR EMBL; AF034950; AAB91470.1; -; Genomic_DNA.
DR RefSeq; NP_803480.1; NM_177514.2.
DR AlphaFoldDB; P32236; -.
DR SMR; P32236; -.
DR STRING; 9913.ENSBTAP00000000559; -.
DR PaxDb; P32236; -.
DR PRIDE; P32236; -.
DR Ensembl; ENSBTAT00000000559; ENSBTAP00000000559; ENSBTAG00000000438.
DR GeneID; 281798; -.
DR KEGG; bta:281798; -.
DR CTD; 2798; -.
DR VEuPathDB; HostDB:ENSBTAG00000000438; -.
DR VGNC; VGNC:29482; GNRHR.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244841; -.
DR HOGENOM; CLU_009579_15_2_1; -.
DR InParanoid; P32236; -.
DR OMA; SEPVNHF; -.
DR OrthoDB; 858238at2759; -.
DR TreeFam; TF106499; -.
DR Reactome; R-BTA-375281; Hormone ligand-binding receptors.
DR Reactome; R-BTA-416476; G alpha (q) signalling events.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000000438; Expressed in pituitary gland and 10 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001658; GphnRH_fam_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00529; GNADOTRPHINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..328
FT /note="Gonadotropin-releasing hormone receptor"
FT /id="PRO_0000069483"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..300
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..326
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 327..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 328 AA; 37741 MW; 845312BAB53B4F72 CRC64;
MANSDSPEQN ENHCSAINSS IPLTPGSLPT LTLSGKIRVT VTFFLFLLST IFNTSFLLKL
QNWTQRKEKR KKLSRMKLLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKVLSYL
KLFSMYAPAF MMVVISLDRS LAITKPLAVK SNSKLGQFMI GLAWLLSSIF AGPQLYIFGM
IHLADDSGQT EGFSQCVTHC SFPQWWHQAF YNFFTFSCLF IIPLLIMVIC NAKIIFTLTR
VLHQDPHKLQ LNQSKNNIPR ARLRTLKMTV AFATSFTVCW TPYYVLGIWY WFDPDMVNRV
SDPVNHFFFL FAFLNPCFDP LIYGYFSL
