ID   GNRHR_CAVPO             Reviewed;         328 AA.
AC   Q8CH60;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Gonadotropin-releasing hormone receptor;
DE            Short=GnRH receptor;
DE            Short=GnRH-R;
GN   Name=GNRHR;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley;
RA   Fujii Y., Ikemoto T., Park M.K.;
RT   "Molecular cloning of a GnRH receptor in the guinea pig.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that
CC       mediates the action of GnRH to stimulate the secretion of the
CC       gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating
CC       hormone (FSH). This receptor mediates its action by association with G-
CC       proteins that activate a phosphatidylinositol-calcium second messenger
CC       system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF426176; AAN75711.2; -; mRNA.
DR   RefSeq; NP_001166428.1; NM_001172957.2.
DR   AlphaFoldDB; Q8CH60; -.
DR   SMR; Q8CH60; -.
DR   STRING; 10141.ENSCPOP00000013163; -.
DR   Ensembl; ENSCPOT00000014754; ENSCPOP00000013163; ENSCPOG00000014609.
DR   GeneID; 100135532; -.
DR   KEGG; cpoc:100135532; -.
DR   CTD; 2798; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244841; -.
DR   HOGENOM; CLU_009579_15_2_1; -.
DR   InParanoid; Q8CH60; -.
DR   OMA; SEPVNHF; -.
DR   OrthoDB; 858238at2759; -.
DR   TreeFam; TF106499; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000014609; Expressed in pituitary gland and 1 other tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IEA:Ensembl.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001658; GphnRH_fam_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00529; GNADOTRPHINR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="Gonadotropin-releasing hormone receptor"
FT                   /id="PRO_0000069485"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..84
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..115
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..160
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..306
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        114..196
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   328 AA;  37690 MW;  7DCE4E9609D2B161 CRC64;
     MQDDTSSEQN PTHCSAINSS VPLVQGALPT LTLSGKIRVT VTFFLFLVST TLNASFLLKL
     QKWTQKKEKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKILSYL
     KLFSMYAPAF MMVVISLDRS MAITRPLPVQ SNRKLEQSMT GLAWGLSSVL AGPQLYIFKM
     IHLENGPGQT EVFSQCVTHC SFPQWWHQAF YNFFTFICLF IIPLLIMLIC NAKIIFTLTQ
     VLQQDSNKLQ LNQSKNNIPR ARLRTLKMTV AFAASFIVCW TPYYVLGLWY WFDPGMLHRM
     SEPVNHFFFL FAFLNPCFDP LIYGYFSL