ID   GNRHR_HORSE             Reviewed;         328 AA.
AC   O18821;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   04-MAY-2001, sequence version 3.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Gonadotropin-releasing hormone receptor;
DE            Short=GnRH receptor;
DE            Short=GnRH-R;
GN   Name=GNRHR;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Porter M.B., Green M.L., Simmen R.C.M., Sharp D.C.;
RT   "Cloning and sequencing of the equine pituitary gonadotropin-releasing
RT   hormone receptor and expression of its mRNA following administration of
RT   pulsatile or continuous GnRH.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that
CC       mediates the action of GnRH to stimulate the secretion of the
CC       gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating
CC       hormone (FSH). This receptor mediates its action by association with G-
CC       proteins that activate a phosphatidylinositol-calcium second messenger
CC       system (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF018072; AAC27099.2; -; mRNA.
DR   RefSeq; NP_001075305.1; NM_001081836.1.
DR   AlphaFoldDB; O18821; -.
DR   SMR; O18821; -.
DR   STRING; 9796.ENSECAP00000004001; -.
DR   PaxDb; O18821; -.
DR   Ensembl; ENSECAT00000005669; ENSECAP00000004001; ENSECAG00000005763.
DR   GeneID; 100033874; -.
DR   KEGG; ecb:100033874; -.
DR   CTD; 2798; -.
DR   VGNC; VGNC:58457; GNRHR.
DR   GeneTree; ENSGT01050000244841; -.
DR   InParanoid; O18821; -.
DR   OrthoDB; 858238at2759; -.
DR   Proteomes; UP000002281; Chromosome 3.
DR   Bgee; ENSECAG00000005763; Expressed in blood and 4 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IBA:GO_Central.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001658; GphnRH_fam_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00529; GNADOTRPHINR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="Gonadotropin-releasing hormone receptor"
FT                   /id="PRO_0000069486"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..84
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..115
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..157
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        179..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        230..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..306
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        114..196
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   328 AA;  37649 MW;  ADD7E25A41EACD0A CRC64;
     MANSASPEQN QNHCSASNSS IPLTQANLPT LTLSGKIRVT VTFFLFLLST TFNASFLLKL
     HKWTQKKENG KKLSKMKVLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKVLSYL
     KLFSMYAPAF MMVVISLDRS LAITRPLAVK SNSKLGRSMI GLAWLLSSIF AGPQLYIFRM
     IHLADSSGQT EGFSQCVTHC SFPQWWHQAF YNFFTFSCLF IIPLLFMLIC NAKIIFTLTR
     VLHQDPHKLQ LNQSKNNIPR ARLRTLKMTV AFATSFTVCW TPYYVLGIWY WFDPEMLNRV
     SDPVNHFFFL FALLNPCFDP LIYGYFSL