ID   GNRHR_MACMU             Reviewed;          59 AA.
AC   Q8SPZ1;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Gonadotropin-releasing hormone receptor;
DE            Short=GnRH receptor;
DE            Short=GnRH-R;
DE   Flags: Fragment;
GN   Name=GNRHR;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Norgren R.B. Jr., Zink M.A., Jia Y., Ojeda S.R., Spindel E.R.;
RT   "Construction of a targeted rhesus macaque microarray.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that
CC       mediates the action of GnRH to stimulate the secretion of the
CC       gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating
CC       hormone (FSH). This receptor mediates its action by association with G-
CC       proteins that activate a phosphatidylinositol-calcium second messenger
CC       system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF478039; AAL85874.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8SPZ1; -.
DR   SMR; Q8SPZ1; -.
DR   STRING; 9544.ENSMMUP00000005039; -.
DR   BindingDB; Q8SPZ1; -.
DR   ChEMBL; CHEMBL5647; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   HOGENOM; CLU_009579_15_2_1; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           <1..59
FT                   /note="Gonadotropin-releasing hormone receptor"
FT                   /id="PRO_0000069488"
FT   TOPO_DOM        1..2
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..23
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..37
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   59 AA;  7090 MW;  B814467FF135B93A CRC64;
     VAFATSFTVC WTPYYVLGIW YWFDPEMLNR VSDPVNHFFF LFAFLNPCFD PLIYGYFSL