GNRHR_MOUSE
ID GNRHR_MOUSE Reviewed; 327 AA.
AC Q01776; Q61611;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Gonadotropin-releasing hormone receptor;
DE Short=GnRH receptor;
DE Short=GnRH-R;
GN Name=Gnrhr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1324422; DOI=10.1210/mend.6.7.1324422;
RA Tsutsumi M., Zhou W., Millar R.P., Mellon P.L., Roberts J.L.,
RA Flanagan C.A., Dong K., Gillo B., Sealfon S.C.;
RT "Cloning and functional expression of a mouse gonadotropin-releasing
RT hormone receptor.";
RL Mol. Endocrinol. 6:1163-1169(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1328228; DOI=10.1016/s0021-9258(19)36602-5;
RA Reinhart J., Mertz L.M., Catt K.J.;
RT "Molecular cloning and expression of cDNA encoding the murine gonadotropin-
RT releasing hormone receptor.";
RL J. Biol. Chem. 267:21281-21284(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ; TISSUE=Liver;
RA Clay C.M., Nelson S.E., Campion C.E., Digregorio G.B.;
RL Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that
CC mediates the action of GnRH to stimulate the secretion of the
CC gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating
CC hormone (FSH). This receptor mediates its action by association with G-
CC proteins that activate a phosphatidylinositol-calcium second messenger
CC system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Pituitary gland.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L01119; AAB59636.1; -; mRNA.
DR EMBL; M93108; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L33789; AAA37716.1; -; Genomic_DNA.
DR EMBL; L33778; AAA37716.1; JOINED; Genomic_DNA.
DR EMBL; L33788; AAA37716.1; JOINED; Genomic_DNA.
DR CCDS; CCDS19379.1; -.
DR PIR; A44013; A44013.
DR RefSeq; NP_034453.1; NM_010323.2.
DR AlphaFoldDB; Q01776; -.
DR SMR; Q01776; -.
DR CORUM; Q01776; -.
DR STRING; 10090.ENSMUSP00000031172; -.
DR BindingDB; Q01776; -.
DR ChEMBL; CHEMBL3232679; -.
DR DrugCentral; Q01776; -.
DR GuidetoPHARMACOLOGY; 256; -.
DR GlyGen; Q01776; 3 sites.
DR iPTMnet; Q01776; -.
DR PhosphoSitePlus; Q01776; -.
DR PaxDb; Q01776; -.
DR PRIDE; Q01776; -.
DR Antibodypedia; 12675; 441 antibodies from 37 providers.
DR DNASU; 14715; -.
DR Ensembl; ENSMUST00000031172; ENSMUSP00000031172; ENSMUSG00000029255.
DR GeneID; 14715; -.
DR KEGG; mmu:14715; -.
DR UCSC; uc008xxl.1; mouse.
DR CTD; 2798; -.
DR MGI; MGI:95790; Gnrhr.
DR VEuPathDB; HostDB:ENSMUSG00000029255; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244841; -.
DR HOGENOM; CLU_009579_15_2_1; -.
DR InParanoid; Q01776; -.
DR OMA; SEPVNHF; -.
DR OrthoDB; 858238at2759; -.
DR PhylomeDB; Q01776; -.
DR TreeFam; TF106499; -.
DR Reactome; R-MMU-375281; Hormone ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 14715; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Gnrhr; mouse.
DR PRO; PR:Q01776; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q01776; protein.
DR Bgee; ENSMUSG00000029255; Expressed in lumbar subsegment of spinal cord and 33 other tissues.
DR ExpressionAtlas; Q01776; baseline and differential.
DR Genevisible; Q01776; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IBA:GO_Central.
DR GO; GO:0016520; F:growth hormone-releasing hormone receptor activity; ISO:MGI.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001658; GphnRH_fam_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00529; GNADOTRPHINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..327
FT /note="Gonadotropin-releasing hormone receptor"
FT /id="PRO_0000069489"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..58
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 59..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..231
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..299
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..305
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..325
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 326..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..195
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 76
FT /note="M -> I (in Ref. 3; AAA37716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 327 AA; 37684 MW; FDDC7B985306FC9F CRC64;
MANNASLEQD PNHCSAINNS IPLIQGKLPT LTVSGKIRVT VTFFLFLLST AFNASFLLKL
QKWTQKRKKG KKLSRMKVLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG EFLCKVLSYL
KLFSMYAPAF MMVVISLDRS LAITQPLAVQ SNSKLEQSMI SLAWILSIVF AGPQLYIFRM
IYLADGSGPT VFSQCVTHCS FPQWWHQAFY NFFTFGCLFI IPLLIMLICN AKIIFALTRV
LHQDPRKLQL NQSKNNIPRA RLRTLKMTVA FATSFVVCWT PYYVLGIWYW FDPEMLNRVS
EPVNHFFFLF AFLNPCFDPL IYGYFSL
