ID   GNRHR_SHEEP             Reviewed;         328 AA.
AC   P32237;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Gonadotropin-releasing hormone receptor;
DE            Short=GnRH receptor;
DE            Short=GnRH-R;
GN   Name=GNRHR;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=7694577; DOI=10.1006/bbrc.1993.2312;
RA   Illing N., Jacobs G.F.M., Becker I.I., Flanagan C.A., Davidson J.S.,
RA   Eales A., Zhou W., Sealfon S.C., Millar R.P.;
RT   "Comparative sequence analysis and functional characterization of the
RT   cloned sheep gonadotropin-releasing hormone receptor reveal differences in
RT   primary structure and ligand specificity among mammalian receptors.";
RL   Biochem. Biophys. Res. Commun. 196:745-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Scottish blackface; TISSUE=Pituitary;
RX   PubMed=8224516; DOI=10.1016/0303-7207(93)90177-l;
RA   Brooks J., Taylor P.L., Sauders P.T.K., Eidne K.A., Struthers W.J.,
RA   McNeilly A.S.;
RT   "Cloning and sequencing of the sheep pituitary gonadotropin-releasing
RT   hormone receptor and changes in expression of its mRNA during the estrous
RT   cycle.";
RL   Mol. Cell. Endocrinol. 94:R23-R27(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=8666259; DOI=10.1016/0378-1119(96)00042-x;
RA   Campion C.E., Turzillo A.M., Clay C.M.;
RT   "The gene encoding the ovine gonadotropin-releasing hormone (GnRH)
RT   receptor: cloning and initial characterization.";
RL   Gene 170:277-280(1996).
CC   -!- FUNCTION: Receptor for gonadotropin releasing hormone (GnRH) that
CC       mediates the action of GnRH to stimulate the secretion of the
CC       gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating
CC       hormone (FSH). This receptor mediates its action by association with G-
CC       proteins that activate a phosphatidylinositol-calcium second messenger
CC       system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; L22215; AAC37336.1; -; mRNA.
DR   EMBL; X72088; CAA50978.1; -; mRNA.
DR   EMBL; L42937; AAB38515.1; -; Genomic_DNA.
DR   EMBL; AH004943; AAB41939.1; -; Genomic_DNA.
DR   PIR; JN0882; JN0882.
DR   RefSeq; NP_001009397.1; NM_001009397.1.
DR   AlphaFoldDB; P32237; -.
DR   SMR; P32237; -.
DR   STRING; 9940.ENSOARP00000008075; -.
DR   Ensembl; ENSOART00000008195; ENSOARP00000008075; ENSOARG00000007526.
DR   Ensembl; ENSOART00020000471; ENSOARP00020000363; ENSOARG00020000382.
DR   GeneID; 443413; -.
DR   KEGG; oas:443413; -.
DR   CTD; 2798; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   HOGENOM; CLU_009579_15_2_1; -.
DR   OMA; SEPVNHF; -.
DR   OrthoDB; 858238at2759; -.
DR   Proteomes; UP000002356; Chromosome 6.
DR   Bgee; ENSOARG00000007526; Expressed in pituitary gland and 14 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IEA:Ensembl.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001658; GphnRH_fam_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00529; GNADOTRPHINR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="Gonadotropin-releasing hormone receptor"
FT                   /id="PRO_0000069492"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..58
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        59..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..97
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..115
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..137
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..164
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..184
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        185..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..232
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..281
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..300
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        301..306
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..326
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        327..328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        114..196
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        8
FT                   /note="D -> N (in Ref. 2; CAA50978)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        27
FT                   /note="S -> R (in Ref. 2; CAA50978)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        64
FT                   /note="T -> A (in Ref. 2; CAA50978)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        312
FT                   /note="A -> G (in Ref. 2; CAA50978)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   328 AA;  37685 MW;  0618374F33ECC6FE CRC64;
     MANGDSPDQN ENHCSAINSS ILLTPGSLPT LTLSGKIRVT VTFFLFLLST IFNTSFLLKL
     QNWTQRKEKR KKLSKMKVLL KHLTLANLLE TLIVMPLDGM WNITVQWYAG ELLCKVLSYL
     KLFSMYAPAF MMVVISLDRS LAITRPLAVK SNSKLGQFMI GLAWLLSSIF AGPQLYIFGM
     IHLADDSGQT EGFSQCVTHC SFPQWWHQAF YNFFTFSCLF IIPLLIMLIC NAKIIFTLTR
     VLHQDPHKLQ LNQSKNNIPQ ARLRTLKMTV AFATSFTVCW TPYYVLGIWY WFDPDMVNRV
     SDPVNHFFFL FAFLNPCFDP LIYGYFSL