GNRR2_CALJA
ID GNRR2_CALJA Reviewed; 380 AA.
AC Q95MG6;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Gonadotropin-releasing hormone II receptor;
DE Short=GnRH II receptor;
DE Short=GnRH-II-R;
DE AltName: Full=Type II GnRH receptor;
GN Name=GNRHR2;
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11493674; DOI=10.1073/pnas.141048498;
RA Millar R., Lowe S., Conklin D., Pawson A., Maudsley S., Troskie B., Ott T.,
RA Millar M., Lincoln G., Sellar R., Faurholm B., Scobie G., Kuestner R.,
RA Terasawa E., Katz A.;
RT "A novel mammalian receptor for the evolutionarily conserved type II
RT GnRH.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9636-9641(2001).
CC -!- FUNCTION: Receptor for gonadotropin releasing hormone II (GnRH II).
CC This receptor mediates its action by association with G proteins that
CC activate a phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylated on the C-terminal cytoplasmic tail. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF368286; AAK60927.1; -; mRNA.
DR RefSeq; NP_001254688.1; NM_001267759.1.
DR AlphaFoldDB; Q95MG6; -.
DR SMR; Q95MG6; -.
DR STRING; 9483.ENSCJAP00000050460; -.
DR iPTMnet; Q95MG6; -.
DR GeneID; 100399755; -.
DR KEGG; cjc:100399755; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q95MG6; -.
DR OrthoDB; 858238at2759; -.
DR Proteomes; UP000008225; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR027983; GphnRH_2_rcpt.
DR InterPro; IPR001658; GphnRH_fam_rcpt.
DR PANTHER; PTHR24241:SF69; PTHR24241:SF69; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00529; GNADOTRPHINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..380
FT /note="Gonadotropin-releasing hormone II receptor"
FT /id="PRO_0000069494"
FT TOPO_DOM 1..40
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..114
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..178
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..297
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..323
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..380
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 113..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 380 AA; 41991 MW; 110637D5ACFA0B1C CRC64;
MSAVNGTPWG SSAREEVWAG SGVEVEGSEL PTFSTAAKVR VGVTIVLFVS SAGGNLAVLW
SVTRPQPSQL RPSPVRRLFA HLAAADLLVT FVVMPLDATW NITVQWLAGD IACRTLMFLK
LMAMYAAAFL PVVIGLDRQA AVLNPLGSRS GVRKLLGAAW GLSFLLALPQ LFLFHTVHRA
GPVPFTQCAT KGSFKARWQE TTYNLFTFCC LFLLPLTAMA ICYSRIVLGV SSPRTRKGSH
APAGEFALRR SFDNRPRVRL RALRLALLVL LTFILCWTPY YLLGLWYWFS PSMLSEVPPS
LSHILFLFGL LNAPLDPLLY GAFTLGCRRG HQELSMDSSR EEGSRRMFQQ DIQALRQTEV
QKTVTSRKAG ETKDIPITSI
