ID   GNRR2_CHLAE             Reviewed;         379 AA.
AC   Q95MH6;
DT   12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Gonadotropin-releasing hormone II receptor;
DE            Short=GnRH II receptor;
DE            Short=GnRH-II-R;
DE   AltName: Full=Type II GnRH receptor;
GN   Name=GNRHR2;
OS   Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=9534;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11352653; DOI=10.1006/bbrc.2001.4678;
RA   Neill J.D., Duck L.W., Sellers J.C., Musgrove L.C.;
RT   "A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in
RT   primates.";
RL   Biochem. Biophys. Res. Commun. 282:1012-1018(2001).
CC   -!- FUNCTION: Receptor for gonadotropin releasing hormone II (GnRH II).
CC       This receptor mediates its action by association with G proteins that
CC       activate a phosphatidylinositol-calcium second messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- PTM: Phosphorylated on the C-terminal cytoplasmic tail. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF353988; AAK52746.1; -; mRNA.
DR   AlphaFoldDB; Q95MH6; -.
DR   SMR; Q95MH6; -.
DR   BindingDB; Q95MH6; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR027983; GphnRH_2_rcpt.
DR   InterPro; IPR001658; GphnRH_fam_rcpt.
DR   PANTHER; PTHR24241:SF69; PTHR24241:SF69; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00529; GNADOTRPHINR.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Phosphoprotein; Receptor; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..379
FT                   /note="Gonadotropin-releasing hormone II receptor"
FT                   /id="PRO_0000069495"
FT   TOPO_DOM        1..40
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..60
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        61..76
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..96
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..114
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..136
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..160
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..178
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        179..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..224
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        225..278
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..297
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..303
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..323
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        324..379
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        113..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   379 AA;  41435 MW;  F1ECA8DD3B8CC1BE CRC64;
     MSAGNGTPWG SAVGEEAWAG SGVAVEGSEL PTFSTAAKVR VGVTIVLFVS SAGGNLAVLW
     SVTRPQPSQL RPSPVRTLFA HLAAADLLVT FVVMPLDATW NITVQWLAGD IACRTLMFLK
     LMAMYSAAFL PVVIGLDRQA AVLNPLGSRS GVRKLLGAAW GLSFLLALPQ LFLFHTVHRA
     GPVPFTQCVT KGSFKARWQE TTYNLFTFCC LFLLPLIAMA ICYSRIVLSV SSPQTRKGSH
     APAGEFALRR SFDNRPRVCL RALRLALLIL LTFILCWTPY YLLGLWYWFS PTMLTEVPPS
     LSHILFLFGL LNAPLDPLLY GAFTFGCRRG HQELSIDSSK EGSGRMLQQE IHALRQQEVQ
     KTVTSRSAGE TKGISITSI