GNRR2_HUMAN
ID GNRR2_HUMAN Reviewed; 292 AA.
AC Q96P88; E7EN27; Q8TCX8;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 4.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=Putative gonadotropin-releasing hormone II receptor;
DE Short=GnRH II receptor;
DE Short=GnRH-II-R;
DE AltName: Full=Type II GnRH receptor;
GN Name=GNRHR2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11707068; DOI=10.1006/geno.2001.6650;
RA Faurholm B., Millar R.P., Katz A.A.;
RT "The genes encoding the type II gonadotropin-releasing hormone receptor and
RT the ribonucleoprotein RBM8A in humans overlap in two genomic loci.";
RL Genomics 78:15-18(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=11861490; DOI=10.1210/endo.143.3.8705;
RA Neill J.D.;
RT "Minireview: GnRH and GnRH receptor genes in the human genome.";
RL Endocrinology 143:737-743(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP FUNCTION.
RX PubMed=12538601; DOI=10.1210/en.2002-220622;
RA Morgan K., Conklin D., Pawson A.J., Sellar R., Ott T.R., Millar R.P.;
RT "A transcriptionally active human type II gonadotropin-releasing hormone
RT receptor gene homolog overlaps two genes in the antisense orientation on
RT chromosome 1q.12.";
RL Endocrinology 144:423-436(2003).
RN [5]
RP FUNCTION.
RX PubMed=19657181; DOI=10.1159/000233303;
RA Stewart A.J., Katz A.A., Millar R.P., Morgan K.;
RT "Retention and silencing of prepro-GnRH-II and type II GnRH receptor genes
RT in mammals.";
RL Neuroendocrinology 90:416-432(2009).
CC -!- FUNCTION: Putative receptor for gonadotropin releasing hormone II (GnRH
CC II) which is most probably non-functional.
CC {ECO:0000269|PubMed:12538601, ECO:0000269|PubMed:19657181}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in many tissues.
CC {ECO:0000269|PubMed:11861490}.
CC -!- PTM: Phosphorylated on the C-terminal cytoplasmic tail. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. A frameshift introducing
CC a premature stop codon in exon 1 most probably results in the
CC inactivation of that transcribed gene in human. However, alternative
CC splicing may allow the production of a truncated but possibly
CC functional protein containing 5 transmembrane domains which is shown
CC here. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL27000.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF403014; AAL27000.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY081843; AAL89821.1; -; mRNA.
DR EMBL; AL160282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q96P88; -.
DR SMR; Q96P88; -.
DR DrugBank; DB01406; Danazol.
DR DrugBank; DB00644; Gonadorelin.
DR DrugBank; DB00666; Nafarelin.
DR PhosphoSitePlus; Q96P88; -.
DR BioMuta; HGNC:16341; -.
DR DMDM; 408360337; -.
DR PaxDb; Q96P88; -.
DR PRIDE; Q96P88; -.
DR GeneCards; GNRHR2; -.
DR HGNC; HGNC:16341; GNRHR2.
DR MIM; 612875; gene.
DR neXtProt; NX_Q96P88; -.
DR InParanoid; Q96P88; -.
DR TreeFam; TF106499; -.
DR PathwayCommons; Q96P88; -.
DR Reactome; R-HSA-375281; Hormone ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR ChiTaRS; GNRHR2; human.
DR Pharos; Q96P88; Tdark.
DR PRO; PR:Q96P88; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q96P88; protein.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004968; F:gonadotropin-releasing hormone receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR027983; GphnRH_2_rcpt.
DR InterPro; IPR001658; GphnRH_fam_rcpt.
DR PANTHER; PTHR24241:SF69; PTHR24241:SF69; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00529; GNADOTRPHINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..292
FT /note="Putative gonadotropin-releasing hormone II receptor"
FT /id="PRO_0000069497"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..177
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 26..101
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 96
FT /note="V -> D (in Ref. 2; AAL89821)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 32537 MW; CB8E31DABE8030FC CRC64;
MSAGNGTPWD ATWNITVQWL AVDIACRTLM FLKLMATYSA AFLPVVIGLD RQAAVLNPLG
SRSGVRKLLG AAWGLSFLLA FPQLFLFHTV HCAGPVPFTQ CVTKGSFKAQ WQETTYNLFT
FCCLFLLPLT AMAICYSRIV LSVSRPQTRK GSHAPAGEFA LPRSFDNCPR VRLRALRLAL
LILLTFILCW TPYYLLGMWY WFSPTMLTEV PPSLSHILFL LGLLNAPLDP LLYGAFTLGC
RRGHQELSID SSKEGSGRML QEEIHAFRQL EVQKTVTSRR AGETKGISIT SI
