ID   GNT12_DICDI             Reviewed;         550 AA.
AC   Q55FD5;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Glycosyltransferase-like protein gnt12;
GN   Name=gnt12; ORFNames=DDB_G0268160;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=17588537; DOI=10.1016/j.bbrc.2007.06.016;
RA   Pang T.L., Wu C.J., Chen P.A., Weng Y.L., Chen M.Y.;
RT   "Dictyostelium gnt15 encodes a protein with similarity to LARGE and plays
RT   an essential role in development.";
RL   Biochem. Biophys. Res. Commun. 360:83-89(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expression peaks at mid- to late-stages of
CC       development. {ECO:0000269|PubMed:17588537}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 8 family. Highly
CC       divergent. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73533.1; -; Genomic_DNA.
DR   RefSeq; XP_647598.1; XM_642506.1.
DR   AlphaFoldDB; Q55FD5; -.
DR   PaxDb; Q55FD5; -.
DR   EnsemblProtists; EAL73533; EAL73533; DDB_G0268160.
DR   GeneID; 8616410; -.
DR   KEGG; ddi:DDB_G0268160; -.
DR   dictyBase; DDB_G0268160; gnt12.
DR   eggNOG; KOG3765; Eukaryota.
DR   HOGENOM; CLU_528327_0_0_1; -.
DR   InParanoid; Q55FD5; -.
DR   PhylomeDB; Q55FD5; -.
DR   PRO; PR:Q55FD5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0042285; F:xylosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0035269; P:protein O-linked mannosylation; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..550
FT                   /note="Glycosyltransferase-like protein gnt12"
FT                   /id="PRO_0000393407"
FT   TOPO_DOM        1..36
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        58..550
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        233
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        322
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        426
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   550 AA;  64059 MW;  64435BCF13BF5F6D CRC64;
     MSYLPLYNNN NNINNNNNNN NNRINNNKEK GVKNKPFQIF ISIVFIVFLC FFLIWSMEAK
     KDKNIKINKI SNIDQKNSPN LINEPINNNK NNKNNIPKNH KQFKNKKGLI KSFQYEPFAY
     KALRNEDGFE ISIVTHVPIE NMEKIAMIAD IWRAPISASV LIKNKNDIDS VYKLIRNSLS
     VSEFVDFHFL YWNEDSDSII NNNNNNIINK NKINTNEEDN LNYYYYPINS LRNLSLKNSK
     TDWILTIDID YLPNYGIYQY LERTLYTSLQ PSKKLINSDL VSFVVPSFQL TSISTKTAPT
     TISTQSPTPI STLKKTTLEN KNKTISTMST TMSTTTTTSA TTNTKITTKI NKPLKKVNRY
     DLPETKFQLQ TFIYDDKLIE ILNKKSCLKC QSPTNYNKWF SLIDTTNPSP YKIEYSWMYD
     PYLLYNKSQL LEFYDERIFK EYPSSSTLSS STTTNDYDKI SFTFSMASQG FQFFILPDAW
     LVKMNDNEDN DNDNDGNNNL IFNNLNNNNN NNEYNENFYI VCNSILPDSK IKNNHNPHKK
     LFNEPLTNEC