GNT14_DICDI
ID GNT14_DICDI Reviewed; 640 AA.
AC Q54PG8;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Glycosyltransferase-like protein gnt14;
GN Name=gnt14; ORFNames=DDB_G0284567;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=17588537; DOI=10.1016/j.bbrc.2007.06.016;
RA Pang T.L., Wu C.J., Chen P.A., Weng Y.L., Chen M.Y.;
RT "Dictyostelium gnt15 encodes a protein with similarity to LARGE and plays
RT an essential role in development.";
RL Biochem. Biophys. Res. Commun. 360:83-89(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at a relatively steady level during
CC vegetative growth and development. {ECO:0000269|PubMed:17588537}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Cells exhibit normal
CC developmental morphology. {ECO:0000269|PubMed:17588537}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 8 family. Highly
CC divergent. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000066; EAL65152.1; -; Genomic_DNA.
DR RefSeq; XP_638506.1; XM_633414.1.
DR AlphaFoldDB; Q54PG8; -.
DR STRING; 44689.DDB0231852; -.
DR PaxDb; Q54PG8; -.
DR EnsemblProtists; EAL65152; EAL65152; DDB_G0284567.
DR GeneID; 8624656; -.
DR KEGG; ddi:DDB_G0284567; -.
DR dictyBase; DDB_G0284567; gnt14.
DR eggNOG; KOG3765; Eukaryota.
DR HOGENOM; CLU_427915_0_0_1; -.
DR InParanoid; Q54PG8; -.
DR PRO; PR:Q54PG8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IBA:GO_Central.
DR GO; GO:0042285; F:xylosyltransferase activity; IBA:GO_Central.
DR GO; GO:0035269; P:protein O-linked mannosylation; IBA:GO_Central.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..640
FT /note="Glycosyltransferase-like protein gnt14"
FT /id="PRO_0000393409"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..640
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 63..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 410
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 539
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 640 AA; 74409 MW; 86ED52889F2BA70A CRC64;
MFGFKTTKNK KRVRLLVVAI GVMIFFMCLS NFSSIQSRQS SSTDTPLQQN GKHQVIRVLE
TQPSININNS ENNINNENIN NNQNNNPNNN MDNNNKNNNK NNNIDNNNNK NNNNNDNIDN
NINNNNNNNN NNNNINNNNN INNNNNIDNT DNNINNNINN NNININNNNK PSYKKPEKKP
PLSSSQIFFN SLPPHIQKQV VIREKSNYAQ ALQYDSYGIV PAKDFFDGLD AVFETKPNYK
ISTVRKLFNI ENLNSNNNNN NNNNNNNNNN NNNNNNYDIN NYNNINIKED DKFENKNYQN
GDKNIMYSDY KGIDYGNNNN IEEIERIKEE LKIELEKENV NDIFKYRVTI VTQTTVDRLY
KVAAMAERWR SPISVSLFIK SQGDIDKLEK AISANKILAT FADFHLFYHN NTRYPVNNLR
NLAIRNALTE HVLLLDVDFI PPSHLHDHIA HYINLNYLNQ DDSLNAFVIP SFSSNLQPKD
IPDSKFEFIE MLTKNKIEPS NLKVCPKCHS PTDYTRWMTS TEPYAIEYHW IYEPFLVYNR
SQTLPFDERF KGYGFDKNSQ IFGMAAQGFT FSVLPEAYIV HINHPTSRWD GPSLDDQQWD
SLRVVCDLLP EIRKRYAKGY KVDRLFDEPT TENCYSNDHW
