ID   GNT1_CANAL              Reviewed;         462 AA.
AC   Q59ZI3; A0A1D8PHA6;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Glucose N-acetyltransferase 1;
DE            EC=2.4.1.-;
DE   AltName: Full=N-acetylglucosaminyltransferase;
GN   Name=GNT1; OrderedLocusNames=CAALFM_C205050CA;
GN   ORFNames=CaO19.11020, CaO19.3536;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: N-acetylglucosaminyltransferase involved in the Golgi-
CC       specific modification of N-linked glycans. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC       pass type II membrane protein {ECO:0000250}. Vacuole membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GNT1 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27523.1; -; Genomic_DNA.
DR   RefSeq; XP_714895.1; XM_709802.1.
DR   AlphaFoldDB; Q59ZI3; -.
DR   STRING; 237561.Q59ZI3; -.
DR   GeneID; 3643450; -.
DR   KEGG; cal:CAALFM_C205050CA; -.
DR   CGD; CAL0000177663; orf19.11020.
DR   VEuPathDB; FungiDB:C2_05050C_A; -.
DR   eggNOG; KOG1950; Eukaryota.
DR   HOGENOM; CLU_034860_1_2_1; -.
DR   InParanoid; Q59ZI3; -.
DR   OMA; ILPHRVY; -.
DR   OrthoDB; 1424146at2759; -.
DR   PRO; PR:Q59ZI3; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008375; F:acetylglucosaminyltransferase activity; IEA:InterPro.
DR   GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006487; P:protein N-linked glycosylation; IEA:InterPro.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR030518; GNT1.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR11183:SF121; PTHR11183:SF121; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase;
KW   Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..462
FT                   /note="Glucose N-acetyltransferase 1"
FT                   /id="PRO_0000087532"
FT   TOPO_DOM        1..18
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        19..35
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..462
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           171..173
FT                   /note="DXD"
SQ   SEQUENCE   462 AA;  55312 MW;  4EB71727636B916C CRC64;
     MTSKSSSWKA LLKNWEFKVA AFIGIYFLIS HVVLETTDVV NEKGLKSHLK VLPEEVIDYY
     GKQPFSNVDK YAYMQYATNY DYLNLAIINF IHLRKANTKI PNLVIIYDEV LHYYASDKWS
     ELYQVANQYK ITLKAAPLIK ASYQDDSNWA ASFTKFHIFN QVEYDRIVFF DSDSMLVDIP
     NEIDFDNMES RFNHIDELFK IPQELSFASP QAYWLNNVVE GKSPRPRKNV EIPNKKRYSL
     RMKKLVNDLS IYQDFNLLPS LIYENHYFDN ANHFFANHIM VITPSKNTFQ ELMRYIHNPW
     WWSITNRGSL RKPNDYDMEI LNKYLNNELQ RKRINVGILP HRVYGVLTGE FGEEWHERFV
     VEPQYLPFIN KKSNKGWSPL EFFKKIKVVH FSDSPIPKPW EEENNEEHYN IKKIYCDKGD
     MEKFHKDYPV YKPRLTDDCD SVSIWNWFRE QFYKERSGYW FA