GNT1_GIBZE
ID GNT1_GIBZE Reviewed; 450 AA.
AC Q4HVS2; A0A0E0SIU1; I1S2E4;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-SEP-2016, sequence version 2.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Glucose N-acetyltransferase 1;
DE EC=2.4.1.-;
DE AltName: Full=N-acetylglucosaminyltransferase;
GN Name=GNT1; ORFNames=FGRRES_17495, FGSG_10936;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: N-acetylglucosaminyltransferase involved in the Golgi-
CC specific modification of N-linked glycans. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type II membrane protein {ECO:0000250}. Vacuole membrane
CC {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GNT1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ESU17817.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; DS231670; ESU17817.1; ALT_SEQ; Genomic_DNA.
DR EMBL; HG970334; CEF86354.1; -; Genomic_DNA.
DR RefSeq; XP_011325439.1; XM_011327137.1.
DR AlphaFoldDB; Q4HVS2; -.
DR SMR; Q4HVS2; -.
DR STRING; 5518.FGSG_10936P0; -.
DR EnsemblFungi; ESU17817; ESU17817; FGSG_10936.
DR GeneID; 23557813; -.
DR KEGG; fgr:FGSG_10936; -.
DR eggNOG; KOG1950; Eukaryota.
DR HOGENOM; CLU_034860_2_1_1; -.
DR InParanoid; Q4HVS2; -.
DR Proteomes; UP000070720; Chromosome 3.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008375; F:acetylglucosaminyltransferase activity; IEA:InterPro.
DR GO; GO:0006487; P:protein N-linked glycosylation; IEA:InterPro.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR030518; GNT1.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR11183:SF121; PTHR11183:SF121; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Signal-anchor;
KW Transferase; Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..450
FT /note="Glucose N-acetyltransferase 1"
FT /id="PRO_0000087535"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..450
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 122..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 258..260
FT /note="DXD"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 450 AA; 52390 MW; D87E8DED8A0A13C1 CRC64;
MGEASSFVAV RLMRIIPILA ILGATYYIFL TCFASFQATD VPVPEEWRNH DAVVDEVDEI
TETLTHDPDS RPTPHKLTIA EIEDLENKGE FMGFEDEDEI DVFINLDDDG DWEEDDLKKE
LGDELEGDFE DEEDEDFGDD DDDDDNDDDV DWSRFAYIQY VTNEDYLCNS VMIFEQLHRL
GSKADRLLMY PKEMLEPDAA YSNKRGGQLL IRARDEYNVT LQPIEIQHRD GQDETWADSF
TKLLAFNQTQ YDRVLSLDSD SMVLQHMDEL FQLPPCPVAM PRAYWLYNEN PPKRILSSQV
MLIQPDDVEF ERIVQKMNSI GPNDYDMEIV NSLYLDSALI LPHRKYDMLT AEFRNKDHTA
YLGSEREKWD SSVALSEAKF VHFSDWPVPK PWINDVETRL ANQPDCPEGE TSCPDRDIWN
GFYTDFTDNK KRVCESVGKT GQKWIHWRRM
