GNTK_ARATH
ID GNTK_ARATH Reviewed; 189 AA.
AC Q9SLE0; Q8LDN6;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Gluconokinase {ECO:0000303|PubMed:12447540};
DE EC=2.7.1.12 {ECO:0000250|UniProtKB:Q5FQ97};
DE AltName: Full=Gluconate kinase {ECO:0000303|PubMed:12447540};
GN OrderedLocusNames=At2g16790 {ECO:0000312|Araport:AT2G16790};
GN ORFNames=T24I21.20 {ECO:0000312|EMBL:AEC06538.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP REVIEW.
RX PubMed=12447540; DOI=10.1007/s00425-002-0842-1;
RA Garlick A.P., Moore C., Kruger N.J.;
RT "Monitoring flux through the oxidative pentose phosphate pathway using [1-
RT 14C]gluconate.";
RL Planta 216:265-272(2002).
CC -!- FUNCTION: Phosphorylates gluconate to 6-phosphogluconate.
CC {ECO:0000250|UniProtKB:Q5FQ97}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+);
CC Xref=Rhea:RHEA:19433, ChEBI:CHEBI:15378, ChEBI:CHEBI:18391,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58759, ChEBI:CHEBI:456216;
CC EC=2.7.1.12; Evidence={ECO:0000250|UniProtKB:Q5FQ97};
CC -!- PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation.
CC {ECO:0000250|UniProtKB:Q5FQ97}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q5FQ97}.
CC -!- SIMILARITY: Belongs to the gluconokinase GntK/GntV family.
CC {ECO:0000305}.
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DR EMBL; AC005825; AAD24612.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC06538.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM63213.1; -; Genomic_DNA.
DR EMBL; AY085892; AAM63104.1; -; mRNA.
DR PIR; C84544; C84544.
DR RefSeq; NP_001325317.1; NM_001335492.1.
DR RefSeq; NP_565393.1; NM_127231.2.
DR AlphaFoldDB; Q9SLE0; -.
DR SMR; Q9SLE0; -.
DR STRING; 3702.AT2G16790.1; -.
DR PaxDb; Q9SLE0; -.
DR ProteomicsDB; 247016; -.
DR EnsemblPlants; AT2G16790.1; AT2G16790.1; AT2G16790.
DR EnsemblPlants; AT2G16790.5; AT2G16790.5; AT2G16790.
DR GeneID; 816180; -.
DR Gramene; AT2G16790.1; AT2G16790.1; AT2G16790.
DR Gramene; AT2G16790.5; AT2G16790.5; AT2G16790.
DR KEGG; ath:AT2G16790; -.
DR Araport; AT2G16790; -.
DR TAIR; locus:2059878; AT2G16790.
DR eggNOG; KOG3354; Eukaryota.
DR InParanoid; Q9SLE0; -.
DR OMA; ENFIQVS; -.
DR PhylomeDB; Q9SLE0; -.
DR UniPathway; UPA00792; -.
DR PRO; PR:Q9SLE0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SLE0; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046316; F:gluconokinase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046177; P:D-gluconate catabolic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd02021; GntK; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR006001; Therm_gnt_kin.
DR PANTHER; PTHR43442; PTHR43442; 1.
DR Pfam; PF01202; SKI; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01313; therm_gnt_kin; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Gluconate utilization; Hydrolase; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..189
FT /note="Gluconokinase"
FT /id="PRO_0000441919"
FT BINDING 16..23
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 13
FT /note="A -> V (in Ref. 3; AAM63104)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="G -> V (in Ref. 3; AAM63104)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 189 AA; 20969 MW; A24B234B145F1720 CRC64;
MSAKNDVTGK VIAIMGVSGA GKSTIGKMLG KALSCDFLDA DDFHSLSNRD KMRQGIALSD
EDRMPWLEKI QESLRKRLLD GETVVLACSS LRKQYREILR GSDPDYKPGS YTSCKVTFVL
LEGNAEVIAA RLQKRASEEE HFMPLTLLQS QFDLLQADEC EKIFKISVVL SPEVIVNTIL
EMVANSLNP
