ID   GNTK_BACSU              Reviewed;         513 AA.
AC   P12011;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Gluconokinase;
DE            EC=2.7.1.12;
DE   AltName: Full=Gluconate kinase;
GN   Name=gntK; OrderedLocusNames=BSU40060;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3020045; DOI=10.1016/s0021-9258(18)67083-8;
RA   Fujita Y., Fujita T., Miwa Y., Nihashi J., Aratani Y.;
RT   "Organization and transcription of the gluconate operon, gnt, of Bacillus
RT   subtilis.";
RL   J. Biol. Chem. 261:13744-13753(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=7584049; DOI=10.1093/dnares/2.2.61;
RA   Yoshida K., Seki S., Fujimura M., Miwa Y., Fujita Y.;
RT   "Cloning and sequencing of a 36-kb region of the Bacillus subtilis genome
RT   between the gnt and iol operons.";
RL   DNA Res. 2:61-69(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+);
CC         Xref=Rhea:RHEA:19433, ChEBI:CHEBI:15378, ChEBI:CHEBI:18391,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58759, ChEBI:CHEBI:456216;
CC         EC=2.7.1.12;
CC   -!- ACTIVITY REGULATION: Catabolite repression by gluconate.
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation.
CC   -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
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DR   EMBL; J02584; AAA56925.1; -; Genomic_DNA.
DR   EMBL; AB005554; BAA21578.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB16043.1; -; Genomic_DNA.
DR   PIR; B26190; B26190.
DR   RefSeq; NP_391886.1; NC_000964.3.
DR   RefSeq; WP_009968422.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P12011; -.
DR   SMR; P12011; -.
DR   STRING; 224308.BSU40060; -.
DR   jPOST; P12011; -.
DR   PaxDb; P12011; -.
DR   PRIDE; P12011; -.
DR   EnsemblBacteria; CAB16043; CAB16043; BSU_40060.
DR   GeneID; 937713; -.
DR   KEGG; bsu:BSU40060; -.
DR   PATRIC; fig|224308.179.peg.4333; -.
DR   eggNOG; COG1070; Bacteria.
DR   InParanoid; P12011; -.
DR   OMA; SDAMHFK; -.
DR   PhylomeDB; P12011; -.
DR   BioCyc; BSUB:BSU40060-MON; -.
DR   UniPathway; UPA00792; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046316; F:gluconokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046177; P:D-gluconate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000577; Carb_kinase_FGGY.
DR   InterPro; IPR018485; Carb_kinase_FGGY_C.
DR   InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR   InterPro; IPR018484; Carb_kinase_FGGY_N.
DR   InterPro; IPR006002; Gluconate_kinase.
DR   Pfam; PF02782; FGGY_C; 1.
DR   Pfam; PF00370; FGGY_N; 1.
DR   PIRSF; PIRSF000538; GlpK; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   TIGRFAMs; TIGR01314; gntK_FGGY; 1.
DR   PROSITE; PS00933; FGGY_KINASES_1; 1.
DR   PROSITE; PS00445; FGGY_KINASES_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Gluconate utilization; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..513
FT                   /note="Gluconokinase"
FT                   /id="PRO_0000059544"
FT   BINDING         16
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         261
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         300
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         412..416
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   513 AA;  57169 MW;  351D44064C7AC3ED CRC64;
     MTSYMLGIDI GTTSTKAVLF SENGDVVQKE SIGYPLYTPD ISTAEQNPEE IFQAVIHTTA
     RITKQHPEKR ISFISFSSAM HSVIAIDEND KPLTPCITWA DNRSEGWAHK IKEELNGHEV
     YKRTGTPIHP MAPLSKIAWI TNERKEIASK AKKYIGIKEY IFKQLFNEYV IDYSLASATG
     MMNLKGLDWD EEALRIAGIT PDHLSKLVPT TEIFQHCSPE IAIQMGIDPE TPFVIGASDG
     VLSNLGVNAI KKGEIAVTIG TSGAIRTIID KPQTDEKGRI FCYALTDKHW VIGGPVNNGG
     IVLRWIRDEF ASSEIETATR LGIDPYDVLT KIAQRVRPGS DGLLFHPYLA GERAPLWNPD
     VRGSFFGLTM SHKKEHMIRA ALEGVIYNLY TVFLALTECM DGPVTRIQAT GGFARSEVWR
     QMMSDIFESE VVVPESYESS CLGACILGLY ATGKIDSFDA VSDMIGSTYR HTPIEDSAKE
     YRTLMPIFIN LSRLLENQYT QIADYQRGLI THK