ID   GNTK_MOUSE              Reviewed;         184 AA.
AC   Q8R0J8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Probable gluconokinase;
DE            EC=2.7.1.12;
DE   AltName: Full=Gluconate kinase;
GN   Name=Idnk;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+);
CC         Xref=Rhea:RHEA:19433, ChEBI:CHEBI:15378, ChEBI:CHEBI:18391,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58759, ChEBI:CHEBI:456216;
CC         EC=2.7.1.12;
CC   -!- PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation.
CC   -!- SIMILARITY: Belongs to the gluconokinase GntK/GntV family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH26742.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC026742; AAH26742.1; ALT_INIT; mRNA.
DR   CCDS; CCDS36682.1; -.
DR   RefSeq; NP_932121.2; NM_198004.3.
DR   AlphaFoldDB; Q8R0J8; -.
DR   SMR; Q8R0J8; -.
DR   STRING; 10090.ENSMUSP00000060218; -.
DR   iPTMnet; Q8R0J8; -.
DR   PhosphoSitePlus; Q8R0J8; -.
DR   EPD; Q8R0J8; -.
DR   jPOST; Q8R0J8; -.
DR   MaxQB; Q8R0J8; -.
DR   PaxDb; Q8R0J8; -.
DR   PRIDE; Q8R0J8; -.
DR   ProteomicsDB; 271242; -.
DR   Antibodypedia; 13014; 118 antibodies from 21 providers.
DR   Ensembl; ENSMUST00000051490; ENSMUSP00000060218; ENSMUSG00000050002.
DR   GeneID; 75731; -.
DR   KEGG; mmu:75731; -.
DR   UCSC; uc007qth.2; mouse.
DR   CTD; 414328; -.
DR   MGI; MGI:1922981; Idnk.
DR   VEuPathDB; HostDB:ENSMUSG00000050002; -.
DR   eggNOG; KOG3354; Eukaryota.
DR   GeneTree; ENSGT00390000003364; -.
DR   HOGENOM; CLU_077168_4_0_1; -.
DR   InParanoid; Q8R0J8; -.
DR   OMA; ENFIQVS; -.
DR   OrthoDB; 1275465at2759; -.
DR   PhylomeDB; Q8R0J8; -.
DR   TreeFam; TF315136; -.
DR   UniPathway; UPA00792; -.
DR   BioGRID-ORCS; 75731; 4 hits in 75 CRISPR screens.
DR   ChiTaRS; Idnk; mouse.
DR   PRO; PR:Q8R0J8; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q8R0J8; protein.
DR   Bgee; ENSMUSG00000050002; Expressed in facial nucleus and 261 other tissues.
DR   ExpressionAtlas; Q8R0J8; baseline and differential.
DR   Genevisible; Q8R0J8; MM.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046316; F:gluconokinase activity; IBA:GO_Central.
DR   GO; GO:0046177; P:D-gluconate catabolic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd02021; GntK; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR031322; Shikimate/glucono_kinase.
DR   InterPro; IPR006001; Therm_gnt_kin.
DR   PANTHER; PTHR43442; PTHR43442; 1.
DR   Pfam; PF01202; SKI; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01313; therm_gnt_kin; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..184
FT                   /note="Probable gluconokinase"
FT                   /id="PRO_0000327371"
FT   BINDING         11..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   184 AA;  19981 MW;  ADEA93B8EC453C1A CRC64;
     MEAPGVLLVM GVSGSGKSTV GALLASKLGW KFYDADDYHS EENRIKMAKG VPLSDQDRIP
     WLCTLHDILL RDVALGQPVV LACSALKKTY RDILIRGGSD APLKSDDSAK EPLAGGKLLV
     VYLCGSFDII YGRLLQRKGH FMPPELLQSQ FSILEPPSAP ENFIQVSVDK SLPEITAAVM
     EALK