GNTP_BACSU
ID GNTP_BACSU Reviewed; 448 AA.
AC P12012;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Gluconate permease;
GN Name=gntP; OrderedLocusNames=BSU40070;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3020045; DOI=10.1016/s0021-9258(18)67083-8;
RA Fujita Y., Fujita T., Miwa Y., Nihashi J., Aratani Y.;
RT "Organization and transcription of the gluconate operon, gnt, of Bacillus
RT subtilis.";
RL J. Biol. Chem. 261:13744-13753(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=7584049; DOI=10.1093/dnares/2.2.61;
RA Yoshida K., Seki S., Fujimura M., Miwa Y., Fujita Y.;
RT "Cloning and sequencing of a 36-kb region of the Bacillus subtilis genome
RT between the gnt and iol operons.";
RL DNA Res. 2:61-69(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the GntP permease family. {ECO:0000305}.
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DR EMBL; J02584; AAA56926.1; -; Genomic_DNA.
DR EMBL; AB005554; BAA21577.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB16044.1; -; Genomic_DNA.
DR PIR; A26190; A26190.
DR RefSeq; NP_391887.1; NC_000964.3.
DR RefSeq; WP_003243139.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P12012; -.
DR SMR; P12012; -.
DR STRING; 224308.BSU40070; -.
DR TCDB; 2.A.8.1.1; the gluconate:h(+) symporter (gntp) family.
DR PaxDb; P12012; -.
DR DNASU; 937715; -.
DR EnsemblBacteria; CAB16044; CAB16044; BSU_40070.
DR GeneID; 937715; -.
DR KEGG; bsu:BSU40070; -.
DR PATRIC; fig|224308.179.peg.4334; -.
DR eggNOG; COG2610; Bacteria.
DR InParanoid; P12012; -.
DR OMA; LMRIGIP; -.
DR PhylomeDB; P12012; -.
DR BioCyc; BSUB:BSU40070-MON; -.
DR UniPathway; UPA00792; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015128; F:gluconate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0046177; P:D-gluconate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0035429; P:gluconate transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003474; Glcn_transporter.
DR PANTHER; PTHR30354; PTHR30354; 1.
DR Pfam; PF02447; GntP_permease; 1.
DR PIRSF; PIRSF002746; Gluconate_transporter; 1.
DR TIGRFAMs; TIGR00791; gntP; 1.
PE 3: Inferred from homology;
KW Cell membrane; Gluconate utilization; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..448
FT /note="Gluconate permease"
FT /id="PRO_0000061931"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 448 AA; 46655 MW; D89C57EB12B7F199 CRC64;
MPLIIVALGI LALLFLIMGL KLNTFISLLV VSFGVALALG MPFDKVVSSI EAGIGGTLGH
IALIFGLGAM LGKLIADSGG AQRIAMTLVN KFGEKNIQWA VVIASFIIGI ALFFEVGLVL
LIPIVFAISR ELKISILFLG IPMVAALSVT HGFLPPHPGP TAIAGEYGAN IGEVLLYGFI
VAVPTVLIAG PLFTKFAKKI VPASFAKNGN IASLGTQKTF NLEETPGFGI SVFTAMLPII
IMSVATIIDL LQETIGFADN GVLAFIRLIG NASTAMIISL LVAVYTMGIK RNIPVKTVMD
SCSTAISQIG MMLLIIGGGG AFKQVLINGG VGDYVADLFK GTALSPIILA WLIAAILRIS
LGSATVAALS TTGLVIPLLG HSDVNLALVV LATGAGSVIA SHVNDAGFWM FKEYFGLSMK
ETFATWTLLE TIISVAGLGF ILLLSLVV
