GNTR_ECOLI
ID GNTR_ECOLI Reviewed; 331 AA.
AC P0ACP5; P46860; Q2M7A1; Q47241;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=HTH-type transcriptional regulator GntR;
DE AltName: Full=Gluconate utilization system GNT-I transcriptional repressor;
GN Name=gntR; OrderedLocusNames=b3438, JW5946;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9135111; DOI=10.1006/jmbi.1996.0913;
RA Izu H., Adachi O., Yamada M.;
RT "Gene organization and transcriptional regulation of the gntRKU operon
RT involved in gluconate uptake and catabolism of Escherichia coli.";
RL J. Mol. Biol. 267:778-793(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP SEQUENCE REVISION.
RX PubMed=16397293; DOI=10.1093/nar/gkj405;
RA Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R.,
RA Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T.,
RA Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H.,
RA Thomson N.R., Wishart D., Wanner B.L.;
RT "Escherichia coli K-12: a cooperatively developed annotation snapshot
RT -- 2005.";
RL Nucleic Acids Res. 34:1-9(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP CHARACTERIZATION.
RX PubMed=8655507; DOI=10.1128/jb.178.11.3260-3269.1996;
RA Tong S., Porco A., Isturiz T., Conway T.;
RT "Cloning and molecular genetic characterization of the Escherichia coli
RT gntR, gntK, and gntU genes of GntI, the main system for gluconate
RT metabolism.";
RL J. Bacteriol. 178:3260-3269(1996).
CC -!- FUNCTION: Negative regulator for the gluconate utilization system GNT-
CC I, the gntUKR operon.
CC -!- PATHWAY: Carbohydrate acid metabolism; D-gluconate degradation
CC [regulation].
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DR EMBL; D84362; BAA12324.1; -; Genomic_DNA.
DR EMBL; U18997; AAA58236.1; -; Genomic_DNA.
DR EMBL; U00096; AAT48184.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77855.1; -; Genomic_DNA.
DR PIR; A65140; A65140.
DR RefSeq; WP_000730252.1; NZ_SSZK01000008.1.
DR RefSeq; YP_026222.1; NC_000913.3.
DR AlphaFoldDB; P0ACP5; -.
DR SMR; P0ACP5; -.
DR BioGRID; 4259299; 18.
DR DIP; DIP-9822N; -.
DR STRING; 511145.b3438; -.
DR jPOST; P0ACP5; -.
DR PaxDb; P0ACP5; -.
DR PRIDE; P0ACP5; -.
DR EnsemblBacteria; AAT48184; AAT48184; b3438.
DR EnsemblBacteria; BAE77855; BAE77855; BAE77855.
DR GeneID; 60902224; -.
DR GeneID; 947946; -.
DR KEGG; ecj:JW5946; -.
DR KEGG; eco:b3438; -.
DR PATRIC; fig|1411691.4.peg.3291; -.
DR EchoBASE; EB2514; -.
DR eggNOG; COG1609; Bacteria.
DR HOGENOM; CLU_037628_6_3_6; -.
DR InParanoid; P0ACP5; -.
DR OMA; MVFVDRW; -.
DR PhylomeDB; P0ACP5; -.
DR BioCyc; EcoCyc:PD03585; -.
DR UniPathway; UPA00792; -.
DR PRO; PR:P0ACP5; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR GO; GO:0046177; P:D-gluconate catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd01392; HTH_LacI; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF00532; Peripla_BP_1; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..331
FT /note="HTH-type transcriptional regulator GntR"
FT /id="PRO_0000107958"
FT DOMAIN 6..60
FT /note="HTH lacI-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT DNA_BIND 8..27
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ SEQUENCE 331 AA; 36422 MW; 5A40666364E0C896 CRC64;
MKKKRPVLQD VADRVGVTKM TVSRFLRNPE QVSVALRGKI AAALDELGYI PNRAPDILSN
ATSRAIGVLL PSLTNQVFAE VLRGIESVTD AHGYQTMLAH YGYKPEMEQE RLESMLSWNI
DGLILTERTH TPRTLKMIEV AGIPVVELMD SKSPCLDIAV GFDNFEAARQ MTTAIIARGH
RHIAYLGARL DERTIIKQKG YEQAMLDAGL VPYSVMVEQS SSYSSGIELI RQARREYPQL
DGVFCTNDDL AVGAAFECQR LGLKVPDDMA IAGFHGHDIG QVMEPRLASV LTPRERMGSI
GAERLLARIR GESVTPKMLD LGFTLSPGGS I
