ID   GNTR_PAENI              Reviewed;         226 AA.
AC   Q8GAL4;
DT   11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Probable D-xylose utilization operon transcriptional repressor;
DE   AltName: Full=HTH-type transcriptional regulator GntR;
GN   Name=gntR; ORFNames=ORF32;
OS   Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans).
OG   Plasmid pAO1.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Paenarthrobacter.
OX   NCBI_TaxID=29320;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 49919 / DSM 420 / JCM 3874 / NBRC 15511; PLASMID=pAO1;
RX   PubMed=12618462; DOI=10.1128/jb.185.6.1976-1986.2003;
RA   Igloi G.L., Brandsch R.;
RT   "Sequence of the 165-kilobase catabolic plasmid pAO1 from Arthrobacter
RT   nicotinovorans and identification of a pAO1-dependent nicotine uptake
RT   system.";
RL   J. Bacteriol. 185:1976-1986(2003).
RN   [2]
RP   FUNCTION, INDUCTION, AND PATHWAY.
RC   STRAIN=ATCC 49919 / DSM 420 / JCM 3874 / NBRC 15511; PLASMID=pAO1;
RX   PubMed=23063486; DOI=10.1016/j.resmic.2012.10.003;
RA   Mihasan M., Stefan M., Hritcu L., Artenie V., Brandsch R.;
RT   "Evidence of a plasmid-encoded oxidative xylose-catabolic pathway in
RT   Arthrobacter nicotinovorans pAO1.";
RL   Res. Microbiol. 164:22-30(2013).
CC   -!- FUNCTION: Transcriptional regulator involved in the regulation of the
CC       entire oxidative D-xylose degradation pathway via repression of the
CC       corresponding genes. {ECO:0000305|PubMed:23063486}.
CC   -!- PATHWAY: Carbohydrate metabolism; D-xylose degradation [regulation].
CC       {ECO:0000269|PubMed:23063486}.
CC   -!- INDUCTION: Is constitutively expressed at low levels regardless of the
CC       presence or absence of D-xylose. {ECO:0000269|PubMed:23063486}.
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DR   EMBL; AJ507836; CAD47890.1; -; Genomic_DNA.
DR   RefSeq; WP_016359401.1; NC_021229.1.
DR   RefSeq; YP_007988716.1; NC_021229.1.
DR   AlphaFoldDB; Q8GAL4; -.
DR   SMR; Q8GAL4; -.
DR   UniPathway; UPA00810; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:UniProtKB.
DR   GO; GO:0042843; P:D-xylose catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0043469; P:regulation of D-xylose catabolic process; TAS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:UniProtKB.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Plasmid; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..226
FT                   /note="Probable D-xylose utilization operon transcriptional
FT                   repressor"
FT                   /id="PRO_0000429426"
FT   DOMAIN          11..78
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        38..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   226 AA;  24154 MW;  DD6DDC94E3BD7ADE CRC64;
     MDATSKRLTR TTVASQVRDF IVMEIAQGRL PLGAPVREME IAAQLGTSQT PVREAFRELA
     ALGLLESRIH VGTRVRQLAE KDLVEAVPIR SALEGIAGRL AANNYHKHAE EVRGSFEAMK
     EVAEGGDRRV FAAASTTFHR SVVRAAENAS LLRAWNALGI EVMTILAMAS SDIPLDDAAE
     SHRPIVDALE AGDPELAEHA LTHHVAAYLP ATAHSNGGVD AAVQAS