GNTU_ECO57
ID GNTU_ECO57 Reviewed; 446 AA.
AC P0AC97; P46858; P76694; P76695;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Low-affinity gluconate transporter;
DE AltName: Full=Gluconate permease;
DE AltName: Full=Gnt-I system;
GN Name=gntU; OrderedLocusNames=Z4804, ECs4285;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Part of the gluconate utilization system Gnt-I; low-affinity
CC intake of gluconate. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GntP permease family. {ECO:0000305}.
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DR EMBL; AE005174; AAG58545.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37708.1; -; Genomic_DNA.
DR PIR; E86010; E86010.
DR PIR; E91164; E91164.
DR RefSeq; NP_312312.1; NC_002695.1.
DR RefSeq; WP_000210111.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P0AC97; -.
DR STRING; 155864.EDL933_4646; -.
DR EnsemblBacteria; AAG58545; AAG58545; Z4804.
DR EnsemblBacteria; BAB37708; BAB37708; ECs_4285.
DR GeneID; 66672681; -.
DR GeneID; 915858; -.
DR KEGG; ece:Z4804; -.
DR KEGG; ecs:ECs_4285; -.
DR PATRIC; fig|386585.9.peg.4476; -.
DR eggNOG; COG2610; Bacteria.
DR HOGENOM; CLU_027949_0_2_6; -.
DR OMA; MGGILGH; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015128; F:gluconate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR003474; Glcn_transporter.
DR PANTHER; PTHR30354; PTHR30354; 1.
DR Pfam; PF02447; GntP_permease; 1.
DR PIRSF; PIRSF002746; Gluconate_transporter; 1.
DR TIGRFAMs; TIGR00791; gntP; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Gluconate utilization; Membrane;
KW Reference proteome; Sugar transport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..446
FT /note="Low-affinity gluconate transporter"
FT /id="PRO_0000061936"
FT TOPO_DOM 1
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..26
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..109
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..176
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..225
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..261
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..330
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 374..387
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 409..424
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 446
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 446 AA; 46416 MW; 9BC51A785FF80A5F CRC64;
MTTLTLVLTA VGSVLLLLFL VMKARMHAFL ALMVVSMGAG LFSGMPLDKI AATMEKGMGG
TLGFLAVVVA LGAMFGKILH ETGAVDQIAV KMLKSFGHSR AHYAIGLAGL VCALPLFFEV
AIVLLISVAF SMARHTGTNL VKLVIPLFAG VAAAAAFLVP GPAPMLLASQ MNADFGWMIL
IGLCAAIPGM IIAGPLWGNF ISRYVELHIP DDISEPHLGE GKMPSFGFSL SLILLPLVLV
GLKTIAARFV PEGSTAYEWF EFIGHPFTAI LVACLVAIYG LAMRQGMPKD KVMEICGHAL
QPAGIILLVI GAGGVFKQVL VDSGVGPALG EALTGMGLPI AITCFVLAAA VRIIQGSATV
ACLTAVGLVM PVIEQLNYSG AQMAALSICI AGGSIVVSHV NDAGFWLFGK FTGATEAETL
KTWTMMETIL GTVGAIVGMI AFQLLS
