ID   GNTX_ECOLI              Reviewed;         227 AA.
AC   P46846; Q2M778;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=DNA utilization protein YhgH {ECO:0000305|PubMed:16707682};
DE   AltName: Full=Protein GntX;
GN   Name=gntX {ECO:0000303|PubMed:9871335}; Synonyms=yhgH;
GN   OrderedLocusNames=b3413, JW5691;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   FUNCTION.
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9871335;
RX   DOI=10.1002/(sici)1521-4028(199811)38:5/6<395::aid-jobm395>3.0.co;2-7;
RA   Porco A., Alonso G., Isturiz T.;
RT   "The gluconate high affinity transport of GntI in Escherichia coli involves
RT   a multicomponent complex system.";
RL   J. Basic Microbiol. 38:395-404(1998).
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / W3110 / ZK126;
RX   PubMed=16707682; DOI=10.1128/jb.01974-05;
RA   Palchevskiy V., Finkel S.E.;
RT   "Escherichia coli competence gene homologs are essential for competitive
RT   fitness and the use of DNA as a nutrient.";
RL   J. Bacteriol. 188:3902-3910(2006).
CC   -!- FUNCTION: Required for the use of extracellular DNA as a nutrient
CC       (PubMed:16707682). Has been suggested to be involved in gluconate
CC       metabolism (PubMed:9871335). {ECO:0000269|PubMed:16707682,
CC       ECO:0000305|PubMed:9871335}.
CC   -!- DISRUPTION PHENOTYPE: Mutants are unable to use DNA as a sole carbon
CC       and energy source and show decreased competitive fitness when
CC       cocultured with wild-type cells. {ECO:0000269|PubMed:16707682}.
CC   -!- SIMILARITY: Belongs to the ComF/GntX family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA58211.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U18997; AAA58211.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC76438.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77878.1; -; Genomic_DNA.
DR   PIR; H65136; H65136.
DR   RefSeq; NP_417872.2; NC_000913.3.
DR   RefSeq; WP_001333371.1; NZ_SSZK01000008.1.
DR   AlphaFoldDB; P46846; -.
DR   BioGRID; 4261222; 7.
DR   STRING; 511145.b3413; -.
DR   PaxDb; P46846; -.
DR   PRIDE; P46846; -.
DR   EnsemblBacteria; AAC76438; AAC76438; b3413.
DR   EnsemblBacteria; BAE77878; BAE77878; BAE77878.
DR   GeneID; 947915; -.
DR   KEGG; ecj:JW5691; -.
DR   KEGG; eco:b3413; -.
DR   PATRIC; fig|1411691.4.peg.3315; -.
DR   EchoBASE; EB2770; -.
DR   eggNOG; COG1040; Bacteria.
DR   HOGENOM; CLU_054549_0_2_6; -.
DR   InParanoid; P46846; -.
DR   OMA; RYNQSAL; -.
DR   PhylomeDB; P46846; -.
DR   BioCyc; EcoCyc:G7747-MON; -.
DR   PRO; PR:P46846; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0015976; P:carbon utilization; IMP:EcoCyc.
DR   GO; GO:0006308; P:DNA catabolic process; IMP:EcoCyc.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR005222; Competence_ComF.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR00201; comF; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..227
FT                   /note="DNA utilization protein YhgH"
FT                   /id="PRO_0000209458"
SQ   SEQUENCE   227 AA;  25726 MW;  BA8768610CDA03BE CRC64;
     MLTVPGLCWL CRMPLALGHW GICSVCSRAT RTDKTLCPQC GLPATHSHLP CGRCLQKPPP
     WQRLVTVADY APPLSPLIHQ LKFSRRSEIA SALSRLLLLE VLHARRTTGL QLPDRIVSVP
     LWQRRHWRRG FNQSDLLCQP LSRWLHCQWD SEAVTRTRAT ATQHFLSARL RKRNLKNAFR
     LELPVQGRHM VIVDDVVTTG STVAEIAQLL LRNGAAAVQV WCLCRTL