GOG6A_HUMAN
ID GOG6A_HUMAN Reviewed; 693 AA.
AC Q9NYA3; A8K959; Q9NYA7;
DT 03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 3.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Golgin subfamily A member 6A;
DE AltName: Full=Golgin linked to PML;
DE AltName: Full=Golgin-like protein;
GN Name=GOLGA6A; Synonyms=GLP, GOLGA6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT ARG-200.
RC TISSUE=Testis;
RX PubMed=11161787; DOI=10.1006/geno.2000.6388;
RA Gilles F., Goy A., Remache Y., Manova K., Zelenetz A.D.;
RT "Cloning and characterization of a golgin-related gene from the large-scale
RT polymorphism linked to the PML gene.";
RL Genomics 70:364-374(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- INTERACTION:
CC Q9NYA3; Q9BRR9: ARHGAP9; NbExp=3; IntAct=EBI-11163335, EBI-750254;
CC Q9NYA3; Q9UL15: BAG5; NbExp=3; IntAct=EBI-11163335, EBI-356517;
CC Q9NYA3; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-11163335, EBI-8643161;
CC Q9NYA3; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-11163335, EBI-11524851;
CC Q9NYA3; O00311: CDC7; NbExp=3; IntAct=EBI-11163335, EBI-374980;
CC Q9NYA3; Q9H4E7: DEF6; NbExp=3; IntAct=EBI-11163335, EBI-745369;
CC Q9NYA3; Q68J44: DUSP29; NbExp=3; IntAct=EBI-11163335, EBI-1054321;
CC Q9NYA3; Q14241: ELOA; NbExp=3; IntAct=EBI-11163335, EBI-742350;
CC Q9NYA3; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11163335, EBI-744099;
CC Q9NYA3; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-11163335, EBI-7225287;
CC Q9NYA3; Q14192: FHL2; NbExp=3; IntAct=EBI-11163335, EBI-701903;
CC Q9NYA3; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-11163335, EBI-372506;
CC Q9NYA3; P09067: HOXB5; NbExp=3; IntAct=EBI-11163335, EBI-3893317;
CC Q9NYA3; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-11163335, EBI-747204;
CC Q9NYA3; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11163335, EBI-2556193;
CC Q9NYA3; Q7L273: KCTD9; NbExp=3; IntAct=EBI-11163335, EBI-4397613;
CC Q9NYA3; O60341: KDM1A; NbExp=3; IntAct=EBI-11163335, EBI-710124;
CC Q9NYA3; Q9HAQ2: KIF9; NbExp=5; IntAct=EBI-11163335, EBI-8472129;
CC Q9NYA3; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-11163335, EBI-6426443;
CC Q9NYA3; P45984: MAPK9; NbExp=3; IntAct=EBI-11163335, EBI-713568;
CC Q9NYA3; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-11163335, EBI-14086479;
CC Q9NYA3; Q13064: MKRN3; NbExp=3; IntAct=EBI-11163335, EBI-2340269;
CC Q9NYA3; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-11163335, EBI-10288852;
CC Q9NYA3; P00540: MOS; NbExp=3; IntAct=EBI-11163335, EBI-1757866;
CC Q9NYA3; Q96DV4: MRPL38; NbExp=3; IntAct=EBI-11163335, EBI-720441;
CC Q9NYA3; Q9NP98: MYOZ1; NbExp=3; IntAct=EBI-11163335, EBI-744402;
CC Q9NYA3; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-11163335, EBI-5662487;
CC Q9NYA3; O76041: NEBL; NbExp=3; IntAct=EBI-11163335, EBI-2880203;
CC Q9NYA3; O15160: POLR1C; NbExp=3; IntAct=EBI-11163335, EBI-1055079;
CC Q9NYA3; P30153: PPP2R1A; NbExp=3; IntAct=EBI-11163335, EBI-302388;
CC Q9NYA3; P54646: PRKAA2; NbExp=3; IntAct=EBI-11163335, EBI-1383852;
CC Q9NYA3; P25786: PSMA1; NbExp=3; IntAct=EBI-11163335, EBI-359352;
CC Q9NYA3; Q9H0A9-2: SPATC1L; NbExp=5; IntAct=EBI-11163335, EBI-11995806;
CC Q9NYA3; Q9BSW7: SYT17; NbExp=5; IntAct=EBI-11163335, EBI-745392;
CC Q9NYA3; Q9BUZ4: TRAF4; NbExp=3; IntAct=EBI-11163335, EBI-3650647;
CC Q9NYA3; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-11163335, EBI-8451480;
CC Q9NYA3; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11163335, EBI-10241197;
CC Q9NYA3; Q8N0Z6: TTC5; NbExp=3; IntAct=EBI-11163335, EBI-9526213;
CC Q9NYA3; P40222: TXLNA; NbExp=3; IntAct=EBI-11163335, EBI-359793;
CC Q9NYA3; Q9Y4E8-2: USP15; NbExp=3; IntAct=EBI-11163335, EBI-12041225;
CC Q9NYA3; O75604: USP2; NbExp=3; IntAct=EBI-11163335, EBI-743272;
CC Q9NYA3; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-11163335, EBI-11737646;
CC Q9NYA3; Q9BW85: YJU2; NbExp=3; IntAct=EBI-11163335, EBI-10300345;
CC Q9NYA3; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-11163335, EBI-14104088;
CC -!- TISSUE SPECIFICITY: Highly expressed in seminiferous tubes in testis.
CC Highly expressed in spermatids, barely detectable in late pachytene
CC spermatocytes, and not detectable in spermatogonia. Detected at
CC intermediate levels in pancreas and lymph nodes, and at much lower
CC levels in spleen, peripheral blood leukocytes, skeletal muscle, liver,
CC lung, placenta, brain and heart.
CC -!- SIMILARITY: Belongs to the GOLGA6 family. {ECO:0000305}.
CC -!- CAUTION: Maps to a duplicated region on chromosome 15; the gene is
CC present in at least 4 almost identical copies. {ECO:0000305}.
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DR EMBL; AF263742; AAF72196.1; -; mRNA.
DR EMBL; AF266285; AAF72535.1; -; Genomic_DNA.
DR EMBL; AK292574; BAF85263.1; -; mRNA.
DR EMBL; AC013486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS32290.1; -.
DR RefSeq; NP_001033729.2; NM_001038640.2.
DR AlphaFoldDB; Q9NYA3; -.
DR SMR; Q9NYA3; -.
DR BioGRID; 131163; 56.
DR IntAct; Q9NYA3; 46.
DR STRING; 9606.ENSP00000290438; -.
DR iPTMnet; Q9NYA3; -.
DR PhosphoSitePlus; Q9NYA3; -.
DR BioMuta; GOLGA6A; -.
DR DMDM; 215274151; -.
DR MassIVE; Q9NYA3; -.
DR PaxDb; Q9NYA3; -.
DR PeptideAtlas; Q9NYA3; -.
DR PRIDE; Q9NYA3; -.
DR ProteomicsDB; 83204; -.
DR Antibodypedia; 26853; 115 antibodies from 22 providers.
DR DNASU; 342096; -.
DR Ensembl; ENST00000290438.3; ENSP00000290438.3; ENSG00000159289.6.
DR GeneID; 342096; -.
DR KEGG; hsa:342096; -.
DR MANE-Select; ENST00000290438.3; ENSP00000290438.3; NM_001038640.2; NP_001033729.2.
DR UCSC; uc002axa.1; human.
DR CTD; 342096; -.
DR DisGeNET; 342096; -.
DR GeneCards; GOLGA6A; -.
DR HGNC; HGNC:13567; GOLGA6A.
DR HPA; ENSG00000159289; Group enriched (liver, testis).
DR MIM; 610288; gene.
DR neXtProt; NX_Q9NYA3; -.
DR OpenTargets; ENSG00000159289; -.
DR PharmGKB; PA38364; -.
DR VEuPathDB; HostDB:ENSG00000159289; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR HOGENOM; CLU_012403_1_2_1; -.
DR InParanoid; Q9NYA3; -.
DR OMA; SQEAMSG; -.
DR OrthoDB; 358120at2759; -.
DR PhylomeDB; Q9NYA3; -.
DR TreeFam; TF316990; -.
DR PathwayCommons; Q9NYA3; -.
DR SignaLink; Q9NYA3; -.
DR BioGRID-ORCS; 342096; 583 hits in 968 CRISPR screens.
DR GenomeRNAi; 342096; -.
DR Pharos; Q9NYA3; Tdark.
DR PRO; PR:Q9NYA3; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9NYA3; protein.
DR Bgee; ENSG00000159289; Expressed in right testis and 97 other tissues.
DR Genevisible; Q9NYA3; HS.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 2.
DR Pfam; PF15070; GOLGA2L5; 3.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..693
FT /note="Golgin subfamily A member 6A"
FT /id="PRO_0000190069"
FT REGION 20..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 14..611
FT /evidence="ECO:0000255"
FT COMPBIAS 20..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 200
FT /note="W -> R (in dbSNP:rs2018461)"
FT /evidence="ECO:0000269|PubMed:11161787"
FT /id="VAR_047540"
FT CONFLICT 86
FT /note="S -> N (in Ref. 1; AAF72196)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="R -> Q (in Ref. 1; AAF72196)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="K -> E (in Ref. 2; BAF85263)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="Q -> H (in Ref. 1; AAF72535)"
FT /evidence="ECO:0000305"
FT CONFLICT 561..566
FT /note="VTDGMR -> LCPLTG (in Ref. 1; AAF72535)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 693 AA; 79946 MW; D54FA366168C27B2 CRC64;
MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS
GGCHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ
MERLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQRIQ ELERALCAVS
TQQQEEDRSS SCREAVLQRW LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER
ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL
QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE AQRVREQERL
CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE
ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA
ASHQNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE
KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DVFYEVSLDN
NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT
