GOG6B_HUMAN
ID GOG6B_HUMAN Reviewed; 693 AA.
AC A6NDN3; A8MYY7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 3.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Golgin subfamily A member 6B;
GN Name=GOLGA6B; Synonyms=GOLGA;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SIMILARITY: Belongs to the GOLGA6 family. {ECO:0000305}.
CC -!- CAUTION: Maps to a duplicated region on chromosome 15; the gene is
CC present in at least 4 almost identical copies. {ECO:0000305}.
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DR EMBL; AC009712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC100827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS10245.2; -.
DR RefSeq; NP_061122.4; NM_018652.4.
DR AlphaFoldDB; A6NDN3; -.
DR SMR; A6NDN3; -.
DR IntAct; A6NDN3; 1.
DR STRING; 9606.ENSP00000408132; -.
DR iPTMnet; A6NDN3; -.
DR PhosphoSitePlus; A6NDN3; -.
DR BioMuta; GOLGA6B; -.
DR EPD; A6NDN3; -.
DR MassIVE; A6NDN3; -.
DR PaxDb; A6NDN3; -.
DR PeptideAtlas; A6NDN3; -.
DR PRIDE; A6NDN3; -.
DR ProteomicsDB; 919; -.
DR Antibodypedia; 43026; 88 antibodies from 23 providers.
DR DNASU; 55889; -.
DR Ensembl; ENST00000421285.4; ENSP00000408132.3; ENSG00000215186.7.
DR GeneID; 55889; -.
DR KEGG; hsa:55889; -.
DR MANE-Select; ENST00000421285.4; ENSP00000408132.3; NM_018652.5; NP_061122.4.
DR UCSC; uc010uks.2; human.
DR CTD; 55889; -.
DR GeneCards; GOLGA6B; -.
DR HGNC; HGNC:32205; GOLGA6B.
DR HPA; ENSG00000215186; Group enriched (liver, testis).
DR neXtProt; NX_A6NDN3; -.
DR OpenTargets; ENSG00000215186; -.
DR PharmGKB; PA162389878; -.
DR VEuPathDB; HostDB:ENSG00000215186; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR HOGENOM; CLU_012403_1_2_1; -.
DR InParanoid; A6NDN3; -.
DR OMA; CEQNETL; -.
DR OrthoDB; 358120at2759; -.
DR PhylomeDB; A6NDN3; -.
DR TreeFam; TF316990; -.
DR PathwayCommons; A6NDN3; -.
DR SignaLink; A6NDN3; -.
DR BioGRID-ORCS; 55889; 73 hits in 922 CRISPR screens.
DR GenomeRNAi; 55889; -.
DR Pharos; A6NDN3; Tdark.
DR PRO; PR:A6NDN3; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A6NDN3; protein.
DR Bgee; ENSG00000215186; Expressed in right testis and 68 other tissues.
DR Genevisible; A6NDN3; HS.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 2.
DR Pfam; PF15070; GOLGA2L5; 3.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome.
FT CHAIN 1..693
FT /note="Golgin subfamily A member 6B"
FT /id="PRO_0000332248"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..611
FT /evidence="ECO:0000255"
FT COMPBIAS 20..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 200
FT /note="R -> W (in dbSNP:rs2081561)"
FT /id="VAR_042994"
SQ SEQUENCE 693 AA; 79913 MW; 462832EB3A4DB159 CRC64;
MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS
GGGHSPGDSQ YQELAVALES SSVTISQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ
MERLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQRIQ ELERALCAVS
TQQQEEDRSS SCREAVLHRR LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER
ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAKPPSLAP PAVTSVVEQL
QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE VQRVREQERL
CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE
ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA
ASQQNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE
KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DDFYEVSLDN
NVEPAPGAAR EGSPHDNPTV QQIVQLSPVM QDT
