GOG6D_HUMAN
ID GOG6D_HUMAN Reviewed; 693 AA.
AC P0CG33;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Golgin subfamily A member 6D;
GN Name=GOLGA6D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SIMILARITY: Belongs to the GOLGA6 family. {ECO:0000305}.
CC -!- CAUTION: Maps to a duplicated region on chromosome 15; the gene is
CC present in at least 4 almost identical copies. {ECO:0000305}.
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DR EMBL; AC068338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45308.1; -.
DR RefSeq; NP_001138696.1; NM_001145224.1.
DR AlphaFoldDB; P0CG33; -.
DR SMR; P0CG33; -.
DR IntAct; P0CG33; 1.
DR iPTMnet; P0CG33; -.
DR PhosphoSitePlus; P0CG33; -.
DR BioMuta; GOLGA6D; -.
DR DMDM; 300680959; -.
DR EPD; P0CG33; -.
DR MassIVE; P0CG33; -.
DR PaxDb; P0CG33; -.
DR PeptideAtlas; P0CG33; -.
DR PRIDE; P0CG33; -.
DR ProteomicsDB; 52463; -.
DR DNASU; 653643; -.
DR Ensembl; ENST00000434739.4; ENSP00000391085.3; ENSG00000140478.16.
DR GeneID; 653643; -.
DR KEGG; hsa:653643; -.
DR MANE-Select; ENST00000434739.4; ENSP00000391085.3; NM_001145224.3; NP_001138696.1.
DR UCSC; uc010uma.3; human.
DR CTD; 653643; -.
DR GeneCards; GOLGA6D; -.
DR HGNC; HGNC:32204; GOLGA6D.
DR HPA; ENSG00000140478; Tissue enriched (testis).
DR neXtProt; NX_P0CG33; -.
DR PharmGKB; PA162389960; -.
DR VEuPathDB; HostDB:ENSG00000140478; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR InParanoid; P0CG33; -.
DR OMA; QRKENAN; -.
DR OrthoDB; 358120at2759; -.
DR PhylomeDB; P0CG33; -.
DR TreeFam; TF316990; -.
DR SignaLink; P0CG33; -.
DR BioGRID-ORCS; 653643; 42 hits in 556 CRISPR screens.
DR GenomeRNAi; 653643; -.
DR Pharos; P0CG33; Tdark.
DR PRO; PR:P0CG33; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; P0CG33; protein.
DR Bgee; ENSG00000140478; Expressed in right testis and 30 other tissues.
DR ExpressionAtlas; P0CG33; baseline and differential.
DR Genevisible; P0CG33; HS.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 2.
DR Pfam; PF15070; GOLGA2L5; 3.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome.
FT CHAIN 1..693
FT /note="Golgin subfamily A member 6D"
FT /id="PRO_0000395400"
FT REGION 20..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 14..611
FT /evidence="ECO:0000255"
FT COMPBIAS 20..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 79896 MW; 90CC350EAA94EE41 CRC64;
MWPQPYLPPH PMMLEESRQN KLAAAKKKLK EYQQRKSPGI PAGAKTKKKK TDSSPETTTS
GGGHSPGDSQ YQELAVALES SSVTINQLNE NIESLKQQKK QVEHQLEEAK KTNNEIHKAQ
MEQLETINIL TLEKADLKTT LYHTKRAARH FEEESKDLAG RLQYSLQHIQ ELERALCAVS
TQQQEEDRSS SCREAVLQRR LQQTIKERAL LNAHVTQVTE SLKQVQLERD EYAKHIKGER
ARWQERMWKM SVEARTLKEE KKRDIHRIQE LERSLSELKN QMAEPPSLAP PAVTSVVEQL
QDEAKHLRQE VEGLEGKLQS QVENNQALSL LSKEQKQRLQ EQEEMLREQE AQRVREQERL
CEQNERLREQ QKTLQEQGER LRKQEQRLRK QEERLRKEEE RLQKQEKRLW DQEERLWKKE
ERLQKQEERL ALSQNHKLDK QLAEPQCSFE DLNNEKKSAL QLEQQVKELQ EKLDEEHLEA
ASQRNQQLET QLSLVALPGE GDGGQHLDSE EEEAPRPTPN IPEDLESREA TSSFMDLPKE
KADGTEQVER RELGFVQPSG VTDGMRESFT VYESQGAVPN TRHQEMEDVI RLAQKEEEMK
VKLLELQELV LPLVGNHEGH GKFLIAAQNP ADEPTPGAPA PQELGAAGEQ DVFYEVSLDN
NVEPAPGVAR EGSPHNNPTV QQIVQLSPVM QDT