GOG7B_HUMAN
ID GOG7B_HUMAN Reviewed; 167 AA.
AC Q2TAP0; Q5T4F5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Golgin subfamily A member 7B;
GN Name=GOLGA7B; Synonyms=C10orf132, C10orf133;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND EXON SHARING WITH CRTAC1.
RX PubMed=17074475; DOI=10.1016/j.matbio.2006.09.006;
RA Steck E., Braeun J., Pelttari K., Kadel S., Kalbacher H., Richter W.;
RT "Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule
RT of human articular cartilage.";
RL Matrix Biol. 26:30-41(2007).
RN [4]
RP FUNCTION, PALMITOYLATION, AND SUBCELLULAR LOCATION.
RX PubMed=31402609; DOI=10.15252/embr.201847472;
RA Woodley K.T., Collins M.O.;
RT "S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate
RT cell adhesion.";
RL EMBO Rep. 20:e47472-e47472(2019).
CC -!- FUNCTION: Play a role in cell adhesion by regulating the plasma
CC membrane localization of the palmitoyltransferase ZDHHC5
CC (PubMed:31402609). May be involved in protein transport from Golgi to
CC cell surface. {ECO:0000269|PubMed:31402609}.
CC -!- INTERACTION:
CC Q2TAP0; O14964: HGS; NbExp=3; IntAct=EBI-13310443, EBI-740220;
CC Q2TAP0; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-13310443, EBI-12837904;
CC Q2TAP0; Q9C0B5: ZDHHC5; NbExp=3; IntAct=EBI-13310443, EBI-2799626;
CC Q2TAP0; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-13310443, EBI-10273713;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31402609}.
CC Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, but not in lung, nor
CC chondrocytes. {ECO:0000269|PubMed:17074475}.
CC -!- PTM: Palmitoylated by ZDHHC5. Palmitoylation is required for the
CC maintenance of ZDHHC5 at the plasma membrane.
CC {ECO:0000269|PubMed:31402609}.
CC -!- MISCELLANEOUS: Shares an exon with the neighboring tail-to-tail
CC oriented gene CRTAC1.
CC -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
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DR EMBL; AL358938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC110810; AAI10811.1; -; mRNA.
DR CCDS; CCDS31265.1; -.
DR RefSeq; NP_001010917.1; NM_001010917.2.
DR AlphaFoldDB; Q2TAP0; -.
DR BioGRID; 135189; 14.
DR IntAct; Q2TAP0; 7.
DR STRING; 9606.ENSP00000359634; -.
DR iPTMnet; Q2TAP0; -.
DR PhosphoSitePlus; Q2TAP0; -.
DR SwissPalm; Q2TAP0; -.
DR BioMuta; GOLGA7B; -.
DR DMDM; 109821405; -.
DR MassIVE; Q2TAP0; -.
DR MaxQB; Q2TAP0; -.
DR PaxDb; Q2TAP0; -.
DR PeptideAtlas; Q2TAP0; -.
DR PRIDE; Q2TAP0; -.
DR ProteomicsDB; 61472; -.
DR Antibodypedia; 31009; 62 antibodies from 13 providers.
DR DNASU; 401647; -.
DR Ensembl; ENST00000370602.6; ENSP00000359634.1; ENSG00000155265.11.
DR GeneID; 401647; -.
DR KEGG; hsa:401647; -.
DR MANE-Select; ENST00000370602.6; ENSP00000359634.1; NM_001010917.3; NP_001010917.1.
DR UCSC; uc001kos.4; human.
DR CTD; 401647; -.
DR DisGeNET; 401647; -.
DR GeneCards; GOLGA7B; -.
DR HGNC; HGNC:31668; GOLGA7B.
DR HPA; ENSG00000155265; Tissue enhanced (brain, choroid plexus, epididymis).
DR MIM; 614189; gene.
DR neXtProt; NX_Q2TAP0; -.
DR OpenTargets; ENSG00000155265; -.
DR PharmGKB; PA164720284; -.
DR VEuPathDB; HostDB:ENSG00000155265; -.
DR eggNOG; KOG4069; Eukaryota.
DR GeneTree; ENSGT00390000000134; -.
DR HOGENOM; CLU_130071_0_1_1; -.
DR InParanoid; Q2TAP0; -.
DR OMA; YCEALAV; -.
DR OrthoDB; 1528169at2759; -.
DR PhylomeDB; Q2TAP0; -.
DR TreeFam; TF313115; -.
DR PathwayCommons; Q2TAP0; -.
DR SignaLink; Q2TAP0; -.
DR BioGRID-ORCS; 401647; 7 hits in 1063 CRISPR screens.
DR GenomeRNAi; 401647; -.
DR Pharos; Q2TAP0; Tdark.
DR PRO; PR:Q2TAP0; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q2TAP0; protein.
DR Bgee; ENSG00000155265; Expressed in right hemisphere of cerebellum and 147 other tissues.
DR ExpressionAtlas; Q2TAP0; baseline and differential.
DR Genevisible; Q2TAP0; HS.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002178; C:palmitoyltransferase complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR019383; Golgin_A_7/ERF4.
DR Pfam; PF10256; Erf4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Golgi apparatus; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..167
FT /note="Golgin subfamily A member 7B"
FT /id="PRO_0000244090"
FT REGION 140..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 78
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 81
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 83
FT /note="T -> M (in Ref. 2; AAI10811)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 167 AA; 18335 MW; 1DB5D42080A4A66C CRC64;
MATEVHNLQE LRRSASLATK VFIQRDYSDG TICQFQTKFP PELDSRIERQ LFEETVKTLN
GFYAEAEKIG GSSYLEGCLA CATAYFIFLC METHYEKVLK KISRYIQEQN EKIFAPRGLL
LTDPVERGMR VIEISIYEDR CSSGSSSSGS SSGSGSSSGG GGGAGAR
