GOG7B_MOUSE
ID GOG7B_MOUSE Reviewed; 167 AA.
AC Q9D428; A8Y5D0; Q3UTK8;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Golgin subfamily A member 7B;
GN Name=GOLGA7B;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
CC -!- FUNCTION: Play a role in cell adhesion by regulating the plasma
CC membrane localization of the palmitoyltransferase ZDHHC5. May be
CC involved in protein transport from Golgi to cell surface.
CC {ECO:0000250|UniProtKB:Q2TAP0}.
CC -!- INTERACTION:
CC Q9D428; Q8VDZ4: Zdhhc5; NbExp=2; IntAct=EBI-25635843, EBI-7057556;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2TAP0}.
CC Golgi apparatus membrane {ECO:0000250|UniProtKB:Q2TAP0}; Lipid-anchor
CC {ECO:0000250|UniProtKB:Q2TAP0}.
CC -!- PTM: Palmitoylated by ZDHHC5. Palmitoylation is required for the
CC maintenance of ZDHHC5 at the plasma membrane.
CC {ECO:0000250|UniProtKB:Q2TAP0}.
CC -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE23972.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK016850; BAB30463.1; -; mRNA.
DR EMBL; AK139354; BAE23972.1; ALT_INIT; mRNA.
DR EMBL; AL603804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC049116; AAH49116.1; -; mRNA.
DR CCDS; CCDS29827.1; -.
DR RefSeq; NP_001135455.1; NM_001141983.1.
DR RefSeq; NP_081970.1; NM_027694.2.
DR AlphaFoldDB; Q9D428; -.
DR IntAct; Q9D428; 1.
DR STRING; 10090.ENSMUSP00000112575; -.
DR PhosphoSitePlus; Q9D428; -.
DR SwissPalm; Q9D428; -.
DR jPOST; Q9D428; -.
DR MaxQB; Q9D428; -.
DR PaxDb; Q9D428; -.
DR PeptideAtlas; Q9D428; -.
DR PRIDE; Q9D428; -.
DR ProteomicsDB; 267741; -.
DR Antibodypedia; 31009; 62 antibodies from 13 providers.
DR DNASU; 71146; -.
DR Ensembl; ENSMUST00000087123; ENSMUSP00000084362; ENSMUSG00000042532.
DR Ensembl; ENSMUST00000122375; ENSMUSP00000112575; ENSMUSG00000042532.
DR GeneID; 71146; -.
DR KEGG; mmu:71146; -.
DR UCSC; uc008hnm.2; mouse.
DR CTD; 401647; -.
DR MGI; MGI:1918396; Golga7b.
DR VEuPathDB; HostDB:ENSMUSG00000042532; -.
DR eggNOG; KOG4069; Eukaryota.
DR GeneTree; ENSGT00390000000134; -.
DR HOGENOM; CLU_130071_0_1_1; -.
DR InParanoid; Q9D428; -.
DR OMA; AMQNERV; -.
DR OrthoDB; 1528169at2759; -.
DR PhylomeDB; Q9D428; -.
DR TreeFam; TF313115; -.
DR BioGRID-ORCS; 71146; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Golga7b; mouse.
DR PRO; PR:Q9D428; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9D428; protein.
DR Bgee; ENSMUSG00000042532; Expressed in visual cortex and 87 other tissues.
DR Genevisible; Q9D428; MM.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002178; C:palmitoyltransferase complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR019383; Golgin_A_7/ERF4.
DR Pfam; PF10256; Erf4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Golgi apparatus; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..167
FT /note="Golgin subfamily A member 7B"
FT /id="PRO_0000244091"
FT REGION 140..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 78
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 81
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 167 AA; 18335 MW; 4A34CB2080A4B167 CRC64;
MATEVHNLQE LRRSASLATK VFIQRDYSDG TICQFQTKFP PELDSRIERQ LFEETVKTLN
GFYAEAEKIG GSSYLEGCLA CATAYFIFLC METHYEKVLK KISRYIQEQN EKVFAPRGLL
LTDPVERGMR VIEISIYEDR CSSGSSSSGS SSGSGSSSAG GGGAGAR
