GOG8B_HUMAN
ID GOG8B_HUMAN Reviewed; 603 AA.
AC A8MQT2; A6NLZ2; O94937; Q2M3S9; Q9NZG8; Q9NZW0; Q9NZW3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Golgin subfamily A member 8B;
DE AltName: Full=Golgin-67;
GN Name=GOLGA8B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ROLE IN AUTOIMMUNE DISEASES, AND
RP SUBCELLULAR LOCATION.
RX PubMed=10677249; DOI=10.1006/jaut.1999.0359;
RA Eystathioy T., Jakymiw A., Fujita D.J., Fritzler M.J., Chan E.K.L.;
RT "Human autoantibodies to a novel Golgi protein golgin-67: high similarity
RT with golgin-95/gm 130 autoantigen.";
RL J. Autoimmun. 14:179-187(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC TISSUE=Leukemic T-cell;
RX PubMed=10660574; DOI=10.1074/jbc.275.6.4137;
RA Jakymiw A., Raharjo E., Rattner J.B., Eystathioy T., Chan E.K.L.,
RA Fujita D.J.;
RT "Identification and characterization of a novel Golgi protein, golgin-67.";
RL J. Biol. Chem. 275:4137-4144(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in maintaining Golgi structure.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC {ECO:0000269|PubMed:10677249}; Peripheral membrane protein
CC {ECO:0000269|PubMed:10677249}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A8MQT2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8MQT2-2; Sequence=VSP_030496;
CC -!- TISSUE SPECIFICITY: Highly expressed in brain, heart and kidney.
CC Detected at lower levels in liver, thymus, spleen, lung and peripheral
CC blood leukocytes. {ECO:0000269|PubMed:10660574}.
CC -!- DOMAIN: Extended rod-like protein with coiled-coil domains.
CC -!- MISCELLANEOUS: Antibodies against GM88 are present in serum from a
CC patient with Sjoegren syndrome. Sera from patients with Sjoegren
CC syndrome often contain antibodies that react with normal components of
CC the Golgi complex.
CC -!- SIMILARITY: Belongs to the GOLGA8 family. {ECO:0000305}.
CC -!- CAUTION: A family of highly similar proteins (GOLGA8A, GOLGA8B,
CC GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated
CC region on chromosome 15q11-15q13. Our sequences are in agreement with
CC HGNC nomenclature. {ECO:0000305}.
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DR EMBL; AF164622; AAF40308.1; -; mRNA.
DR EMBL; AF163441; AAF34136.1; -; mRNA.
DR EMBL; AC027139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC104800; AAI04801.1; -; mRNA.
DR CCDS; CCDS45211.1; -. [A8MQT2-1]
DR RefSeq; NP_001018861.3; NM_001023567.4. [A8MQT2-1]
DR RefSeq; XP_011519898.1; XM_011521596.1.
DR RefSeq; XP_011519899.1; XM_011521597.1.
DR RefSeq; XP_016877699.1; XM_017022210.1.
DR RefSeq; XP_016877700.1; XM_017022211.1.
DR RefSeq; XP_016877701.1; XM_017022212.1.
DR RefSeq; XP_016877702.1; XM_017022213.1.
DR RefSeq; XP_016877704.1; XM_017022215.1.
DR RefSeq; XP_016877705.1; XM_017022216.1.
DR RefSeq; XP_016877706.1; XM_017022217.1.
DR RefSeq; XP_016877707.1; XM_017022218.1.
DR AlphaFoldDB; A8MQT2; -.
DR SMR; A8MQT2; -.
DR BioGRID; 136421; 1.
DR IntAct; A8MQT2; 1.
DR STRING; 9606.ENSP00000343064; -.
DR GlyConnect; 1283; 3 N-Linked glycans (1 site).
DR GlyGen; A8MQT2; 1 site, 3 N-linked glycans (1 site).
DR iPTMnet; A8MQT2; -.
DR PhosphoSitePlus; A8MQT2; -.
DR BioMuta; GOLGA8B; -.
DR jPOST; A8MQT2; -.
DR MassIVE; A8MQT2; -.
DR MaxQB; A8MQT2; -.
DR PaxDb; A8MQT2; -.
DR PeptideAtlas; A8MQT2; -.
DR PRIDE; A8MQT2; -.
DR Antibodypedia; 67287; 67 antibodies from 11 providers.
DR DNASU; 440270; -.
DR Ensembl; ENST00000342314.9; ENSP00000343064.5; ENSG00000215252.12. [A8MQT2-1]
DR Ensembl; ENST00000683415.1; ENSP00000507830.1; ENSG00000215252.12. [A8MQT2-1]
DR GeneID; 440270; -.
DR KEGG; hsa:440270; -.
DR MANE-Select; ENST00000683415.1; ENSP00000507830.1; NM_001023567.5; NP_001018861.3.
DR UCSC; uc001ziq.4; human. [A8MQT2-1]
DR CTD; 440270; -.
DR GeneCards; GOLGA8B; -.
DR HGNC; HGNC:31973; GOLGA8B.
DR HPA; ENSG00000215252; Tissue enhanced (pancreas).
DR MIM; 609619; gene.
DR neXtProt; NX_A8MQT2; -.
DR OpenTargets; ENSG00000215252; -.
DR PharmGKB; PA142671717; -.
DR VEuPathDB; HostDB:ENSG00000215252; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR HOGENOM; CLU_012403_1_2_1; -.
DR InParanoid; A8MQT2; -.
DR OMA; ELTMECE; -.
DR OrthoDB; 358120at2759; -.
DR PhylomeDB; A8MQT2; -.
DR TreeFam; TF316990; -.
DR PathwayCommons; A8MQT2; -.
DR SignaLink; A8MQT2; -.
DR BioGRID-ORCS; 440270; 9 hits in 592 CRISPR screens.
DR ChiTaRS; GOLGA8B; human.
DR GenomeRNAi; 440270; -.
DR Pharos; A8MQT2; Tdark.
DR PRO; PR:A8MQT2; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A8MQT2; protein.
DR Bgee; ENSG00000215252; Expressed in body of pancreas and 92 other tissues.
DR ExpressionAtlas; A8MQT2; baseline and differential.
DR Genevisible; A8MQT2; HS.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; IBA:GO_Central.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Golgi apparatus; Membrane;
KW Reference proteome.
FT CHAIN 1..603
FT /note="Golgin subfamily A member 8B"
FT /id="PRO_0000316091"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..603
FT /note="Golgi-targeting domain"
FT COILED 82..173
FT /evidence="ECO:0000255"
FT COILED 212..440
FT /evidence="ECO:0000255"
FT COMPBIAS 35..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..143
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10660574,
FT ECO:0000303|PubMed:10677249"
FT /id="VSP_030496"
FT CONFLICT 181
FT /note="A -> T (in Ref. 2; AAF34136)"
FT /evidence="ECO:0000305"
FT CONFLICT 352
FT /note="R -> Q (in Ref. 1; AAF40308, 2; AAF34136 and 4;
FT AAI04801)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="A -> S (in Ref. 1; AAF40308)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="Missing (in Ref. 1; AAF40308)"
FT /evidence="ECO:0000305"
FT CONFLICT 394
FT /note="M -> T (in Ref. 1; AAF40308, 2; AAF34136 and 4;
FT AAI04801)"
FT /evidence="ECO:0000305"
FT CONFLICT 428
FT /note="A -> V (in Ref. 1; AAF40308 and 4; AAI04801)"
FT /evidence="ECO:0000305"
FT CONFLICT 452
FT /note="K -> N (in Ref. 2; AAF34136)"
FT /evidence="ECO:0000305"
FT CONFLICT 468
FT /note="S -> A (in Ref. 2; AAF34136)"
FT /evidence="ECO:0000305"
FT CONFLICT 480
FT /note="Q -> R (in Ref. 1; AAF40308, 2; AAF34136 and 4;
FT AAI04801)"
FT /evidence="ECO:0000305"
FT CONFLICT 488
FT /note="A -> V (in Ref. 1; AAF40308, 2; AAF34136 and 4;
FT AAI04801)"
FT /evidence="ECO:0000305"
FT CONFLICT 493
FT /note="D -> N (in Ref. 2; AAF34136)"
FT /evidence="ECO:0000305"
FT CONFLICT 569
FT /note="L -> V (in Ref. 1; AAF40308 and 2; AAF34136)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 603 AA; 67278 MW; E314724D662AC0E4 CRC64;
MAEETGQSKL AAAKKKFKEY WQRNRPGVPA AAKRNTKANG SSPETAASGG CHSSEASSSA
SSSLHARQSP CQEQAAVLNS RSIKISRLND TIKSLKQQKK QVEHQLEEEK KANNEKQKAE
RELEGQIQRL NTEKKKLNTD LYHMKHSLRY FEEESKDLAG RLQRSSQRIG ELEWSLCAVA
ATQKKKPDGF SSRSKALLKR QLEQSIREQI LLKGHVTQLK ESLKEVQLER DQYAEQIKGE
RAQWQQRMRK MSQEVCTLKE EKKHDTHRVE ELERSLSRLK NQMAEPLPPD APAVSSEVEL
QDLRKELERV AGELQAQVEN NQCISLLNRG QKERLREQEE RLQEQQERLR EREKRLQQLA
EPQSDLEELK HENKSALQLE QQVKELQEKL GQVMETLTSA EKEPEAAVPA SGTGGESSGL
MDLLEEKADL REHVEKLELG FIQYRRERCH QKVHRLLTEP GDSAKDASPG GGHHQAGPGQ
GGEEGEAAGA AGDGVAACGS YSEGHGKFLA AARNPAAEPS PGAPAPQELG AADKHGDLCE
ASLTNSVEPA QGEAREGSSQ DNPTAQPVLQ LLGEMQDHQE HPGLGSNCCV PCFCWAWLPR
RRR
