GOG8F_HUMAN
ID GOG8F_HUMAN Reviewed; 430 AA.
AC Q08AF8; A4FTY1; Q1A5X9; Q8NDK0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Putative golgin subfamily A member 8F/8G;
GN Name=GOLGA8F;
GN and
GN Name=GOLGA8G;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=18226259; DOI=10.1186/1471-2164-9-50;
RA Jiang Y.-H., Wauki K., Liu Q., Bressler J., Pan Y., Kashork C.D.,
RA Shaffer L.G., Beaudet A.L.;
RT "Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region
RT and characterization of transcripts for GOLGA8E and WHCD1L1 from the
RT proximal breakpoint region.";
RL BMC Genomics 9:50-50(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-430 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- INTERACTION:
CC Q08AF8; P18848: ATF4; NbExp=7; IntAct=EBI-10181260, EBI-492498;
CC Q08AF8; Q14032: BAAT; NbExp=3; IntAct=EBI-10181260, EBI-8994378;
CC Q08AF8; Q00994: BEX3; NbExp=3; IntAct=EBI-10181260, EBI-741753;
CC Q08AF8; Q5H9J7: BEX5; NbExp=3; IntAct=EBI-10181260, EBI-10243741;
CC Q08AF8; Q99459: CDC5L; NbExp=3; IntAct=EBI-10181260, EBI-374880;
CC Q08AF8; Q96DN0: ERP27; NbExp=3; IntAct=EBI-10181260, EBI-953772;
CC Q08AF8; O14653: GOSR2; NbExp=5; IntAct=EBI-10181260, EBI-4401517;
CC Q08AF8; Q8N4P3: HDDC3; NbExp=3; IntAct=EBI-10181260, EBI-750003;
CC Q08AF8; Q8NC69: KCTD6; NbExp=3; IntAct=EBI-10181260, EBI-2511344;
CC Q08AF8; P50222: MEOX2; NbExp=3; IntAct=EBI-10181260, EBI-748397;
CC Q08AF8; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-10181260, EBI-995714;
CC Q08AF8; Q08499: PDE4D; NbExp=3; IntAct=EBI-10181260, EBI-1642831;
CC Q08AF8; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-10181260, EBI-1105124;
CC Q08AF8; P30153: PPP2R1A; NbExp=3; IntAct=EBI-10181260, EBI-302388;
CC Q08AF8; Q96R06: SPAG5; NbExp=3; IntAct=EBI-10181260, EBI-413317;
CC Q08AF8; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-10181260, EBI-2212028;
CC Q08AF8; O75558: STX11; NbExp=3; IntAct=EBI-10181260, EBI-714135;
CC Q08AF8; P15884: TCF4; NbExp=3; IntAct=EBI-10181260, EBI-533224;
CC Q08AF8; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10181260, EBI-739895;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q08AF8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q08AF8-2; Sequence=VSP_035081;
CC Name=3;
CC IsoId=Q08AF8-3; Sequence=VSP_037944;
CC -!- SIMILARITY: Belongs to the GOLGA8 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. A family of highly
CC similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F,
CC GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13.
CC Our sequences are in agreement with HGNC nomenclature. {ECO:0000305}.
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DR EMBL; DQ309038; ABD73922.1; -; mRNA.
DR EMBL; AC138749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC066774; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC099913; AAH99913.1; -; mRNA.
DR EMBL; BC125193; AAI25194.1; -; mRNA.
DR EMBL; BC125194; AAI25195.1; -; mRNA.
DR EMBL; BC150302; AAI50303.1; -; mRNA.
DR EMBL; AL833871; CAD38728.1; -; mRNA.
DR AlphaFoldDB; Q08AF8; -.
DR SMR; Q08AF8; -.
DR IntAct; Q08AF8; 19.
DR STRING; 9606.ENSP00000454322; -.
DR BioMuta; GOLGA8G; -.
DR DMDM; 121939991; -.
DR jPOST; Q08AF8; -.
DR MassIVE; Q08AF8; -.
DR PaxDb; Q08AF8; -.
DR PeptideAtlas; Q08AF8; -.
DR PRIDE; Q08AF8; -.
DR ProteomicsDB; 58666; -. [Q08AF8-2]
DR Ensembl; ENST00000526619.7; ENSP00000456138.3; ENSG00000153684.16.
DR Ensembl; ENST00000612831.2; ENSP00000481013.2; ENSG00000277090.2.
DR UCSC; uc001zbp.4; human. [Q08AF8-1]
DR GeneCards; GOLGA8F; -.
DR GeneCards; GOLGA8G; -.
DR HGNC; HGNC:32378; GOLGA8F.
DR HGNC; HGNC:25328; GOLGA8G.
DR HPA; ENSG00000153684; Tissue enriched (testis).
DR neXtProt; NX_Q08AF8; -.
DR VEuPathDB; HostDB:ENSG00000153684; -.
DR eggNOG; KOG4725; Eukaryota.
DR HOGENOM; CLU_012403_1_0_1; -.
DR InParanoid; Q08AF8; -.
DR PhylomeDB; Q08AF8; -.
DR PathwayCommons; Q08AF8; -.
DR SignaLink; Q08AF8; -.
DR Pharos; Q08AF8; Tdark.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q08AF8; protein.
DR Bgee; ENSG00000153684; Expressed in left testis and 65 other tissues.
DR ExpressionAtlas; Q08AF8; baseline.
DR Genevisible; Q08AF8; HS.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 2.
PE 5: Uncertain;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..430
FT /note="Putative golgin subfamily A member 8F/8G"
FT /id="PRO_0000314968"
FT REGION 138..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2..217
FT /evidence="ECO:0000255"
FT VAR_SEQ 121..267
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18226259"
FT /id="VSP_035081"
FT VAR_SEQ 195
FT /note="K -> KVKET (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_037944"
FT CONFLICT 232
FT /note="E -> K (in Ref. 3; BC066774)"
FT /evidence="ECO:0000305"
FT CONFLICT 391
FT /note="S -> P (in Ref. 3; AAH99913)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 430 AA; 48405 MW; C758D5AF42EC4171 CRC64;
MEWKLEQSMR EQALLKAQLT QLKESLKEVQ LERDEYAEHL KGERARWQQR MRKMSQEVCS
LKKEKKHDKY RVEKLERSLS KLKHQMAEPL PPEPPAVPSE VELQHLRKEL ERVAGELQAQ
VEYNQRISLL NEGQKERLRE QEERLQEQQE RLPEQEERLQ QLAEPQNSFK ELNNENKSVL
QLEQQVKELQ EKLGKERLEA ASQQKQQLTA QLSLMALPGE GDGGGHLDSE GEEAPRPIPS
IPQDLESREA MSGFMDHLEE KADLSELVEK EELGFFQYYR ERCHQKVYHP ITKPGGSAKD
AAPGGGHHQA GPGQGGDEGE AAGAAGDGVA AGGDYKGHSK FLVTAQNPAH EPSPGAPAPQ
ELGAAHKHGD LCEVSLTDSV EPVQGEAREG SPHDNPTAQP IVQDHQEHPG LGSNCCVPFF
CWAWLPRRRR
