GOG8H_HUMAN
ID GOG8H_HUMAN Reviewed; 632 AA.
AC P0CJ92;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Golgin subfamily A member 8H;
GN Name=GOLGA8H;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SIMILARITY: Belongs to the GOLGA8 family. {ECO:0000305}.
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DR EMBL; AC026150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS61576.1; -.
DR RefSeq; NP_001269419.1; NM_001282490.1.
DR AlphaFoldDB; P0CJ92; -.
DR SMR; P0CJ92; -.
DR iPTMnet; P0CJ92; -.
DR PhosphoSitePlus; P0CJ92; -.
DR BioMuta; GOLGA8H; -.
DR DMDM; 325530054; -.
DR jPOST; P0CJ92; -.
DR MassIVE; P0CJ92; -.
DR MaxQB; P0CJ92; -.
DR PaxDb; P0CJ92; -.
DR PeptideAtlas; P0CJ92; -.
DR PRIDE; P0CJ92; -.
DR ProteomicsDB; 52500; -.
DR Antibodypedia; 69118; 56 antibodies from 9 providers.
DR DNASU; 728498; -.
DR Ensembl; ENST00000566740.2; ENSP00000456894.1; ENSG00000261794.2.
DR GeneID; 728498; -.
DR KEGG; hsa:728498; -.
DR MANE-Select; ENST00000566740.2; ENSP00000456894.1; NM_001282490.2; NP_001269419.1.
DR UCSC; uc032byf.2; human.
DR CTD; 728498; -.
DR GeneCards; GOLGA8H; -.
DR HGNC; HGNC:37443; GOLGA8H.
DR HPA; ENSG00000261794; Tissue enhanced (testis).
DR neXtProt; NX_P0CJ92; -.
DR OpenTargets; ENSG00000261794; -.
DR VEuPathDB; HostDB:ENSG00000261794; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR HOGENOM; CLU_012403_1_2_1; -.
DR InParanoid; P0CJ92; -.
DR OMA; GETHWIL; -.
DR PhylomeDB; P0CJ92; -.
DR TreeFam; TF316990; -.
DR PathwayCommons; P0CJ92; -.
DR SignaLink; P0CJ92; -.
DR BioGRID-ORCS; 728498; 10 hits in 516 CRISPR screens.
DR GenomeRNAi; 728498; -.
DR Pharos; P0CJ92; Tdark.
DR PRO; PR:P0CJ92; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; P0CJ92; protein.
DR Bgee; ENSG00000261794; Expressed in sural nerve and 91 other tissues.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 2.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome.
FT CHAIN 1..632
FT /note="Golgin subfamily A member 8H"
FT /id="PRO_0000405257"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 110..201
FT /evidence="ECO:0000255"
FT COILED 240..468
FT /evidence="ECO:0000255"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 71342 MW; 02B53CB1531D376D CRC64;
MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SVPEKATSGG CQPPGDSATG
FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
NNKKQKAKRV LEVQIQTLNI QKGKLNTDLY HMKRSLRYFE EKSKDLAVCL QHSLQRKGEL
ESVLSNVMAT QKKKANQLSS RSKARTEWKL EQSMREEALL KVQLTQLKES FQQVQLERDE
CAEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
AVPSEVELQH LRKELERVAG ELQAQVKKNQ RISLLNQRQE ERIQEQEERL RKQEERIQEQ
HKSLQQLAKP QSVFEEPNNE NKNALQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP ESREAMSSFM DHLEEKADLS ELVKKKELCF
IHHWRDRCHQ KTHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLCEVS LTSSAQGEAR EDPLLDKPTA
QPIVQDHQEH PGLGSNCCVP LLCWAWLPRR RR
