GOG8I_HUMAN
ID GOG8I_HUMAN Reviewed; 632 AA.
AC A6NC78;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Putative golgin subfamily A member 8I {ECO:0000305};
DE AltName: Full=Golgin subfamily A member 8I pseudogene {ECO:0000305};
GN Name=GOLGA8IP {ECO:0000312|HGNC:HGNC:26660};
GN Synonyms=GOLGA8I {ECO:0000312|HGNC:HGNC:26660},
GN GOLGA9P {ECO:0000312|HGNC:HGNC:26660};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- FUNCTION: May be involved in maintaining Golgi structure.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GOLGA8 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC091565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NC78; -.
DR SMR; A6NC78; -.
DR iPTMnet; A6NC78; -.
DR PhosphoSitePlus; A6NC78; -.
DR BioMuta; HGNC:26660; -.
DR jPOST; A6NC78; -.
DR MassIVE; A6NC78; -.
DR PaxDb; A6NC78; -.
DR PeptideAtlas; A6NC78; -.
DR PRIDE; A6NC78; -.
DR GeneCards; GOLGA8IP; -.
DR HGNC; HGNC:26660; GOLGA8IP.
DR neXtProt; NX_A6NC78; -.
DR InParanoid; A6NC78; -.
DR PhylomeDB; A6NC78; -.
DR TreeFam; TF316990; -.
DR PathwayCommons; A6NC78; -.
DR Pharos; A6NC78; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NC78; protein.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 2.
PE 5: Uncertain;
KW Coiled coil; Golgi apparatus; Membrane; Reference proteome.
FT CHAIN 1..632
FT /note="Putative golgin subfamily A member 8I"
FT /id="PRO_0000328760"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..632
FT /note="Golgi-targeting domain"
FT /evidence="ECO:0000250"
FT REGION 550..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..154
FT /evidence="ECO:0000255"
FT COILED 209..421
FT /evidence="ECO:0000255"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 71330 MW; 1B88983B175FEA86 CRC64;
MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SIPQTATSGG CQPPGDSATG
FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
NIKKQKAKRV LEVQIQTLNI QKEELNTDLY HMKRSLRYFE EKSKDLAVRL QHSLQRKGEL
ESVLSDVMAT QKKKANQLSS PSKAGTEWKL EQSMREEALL KVQLTQLKES FQQLQLERHE
YAEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
AVPSEVELQH LRKELERVAG ALQAQVKNNQ RISLLNRGQE ERIREQEERL RKQEERIQEQ
HKSLQQLAKP QSVFEEPNNE NKSALQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
ALPGEGHGGE HLDSEGEEAP QPMPSVPEDL ESREAMSSFM DHLEEKADLS ELVKKKELCF
IHHWRERCHQ KTHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
NGHRKFLAAA HNPADEPGPG APAPQELGAA DKHGDLCEVS LTSSAQGEAR EDPLLDKPTA
QPIVQDHQEH PGLGSNCCVP FFCWAWLPRR RR
