GOG8J_HUMAN
ID GOG8J_HUMAN Reviewed; 632 AA.
AC A6NMD2; H3BRU0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 3.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Golgin subfamily A member 8J;
GN Name=GOLGA8J;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- SIMILARITY: Belongs to the GOLGA8 family. {ECO:0000305}.
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DR EMBL; AC120045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS61574.1; -.
DR RefSeq; NP_001269401.1; NM_001282472.1.
DR AlphaFoldDB; A6NMD2; -.
DR SMR; A6NMD2; -.
DR BioGRID; 575504; 2.
DR STRING; 9606.ENSP00000456401; -.
DR iPTMnet; A6NMD2; -.
DR PhosphoSitePlus; A6NMD2; -.
DR BioMuta; GOLGA8J; -.
DR jPOST; A6NMD2; -.
DR MassIVE; A6NMD2; -.
DR PaxDb; A6NMD2; -.
DR PeptideAtlas; A6NMD2; -.
DR PRIDE; A6NMD2; -.
DR Antibodypedia; 69034; 55 antibodies from 8 providers.
DR DNASU; 653073; -.
DR Ensembl; ENST00000567927.2; ENSP00000456401.1; ENSG00000179938.13.
DR Ensembl; ENST00000611771.1; ENSP00000480494.1; ENSG00000278119.1.
DR GeneID; 653073; -.
DR KEGG; hsa:653073; -.
DR MANE-Select; ENST00000567927.2; ENSP00000456401.1; NM_001282472.2; NP_001269401.1.
DR UCSC; uc021sgy.3; human.
DR CTD; 653073; -.
DR GeneCards; GOLGA8J; -.
DR HGNC; HGNC:38650; GOLGA8J.
DR HPA; ENSG00000179938; Tissue enriched (testis).
DR neXtProt; NX_A6NMD2; -.
DR PharmGKB; PA165478975; -.
DR VEuPathDB; HostDB:ENSG00000179938; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR HOGENOM; CLU_012403_1_2_1; -.
DR InParanoid; A6NMD2; -.
DR OMA; GHLCEVS; -.
DR OrthoDB; 358120at2759; -.
DR PhylomeDB; A6NMD2; -.
DR TreeFam; TF316990; -.
DR PathwayCommons; A6NMD2; -.
DR BioGRID-ORCS; 653073; 24 hits in 185 CRISPR screens.
DR GenomeRNAi; 653073; -.
DR Pharos; A6NMD2; Tdark.
DR PRO; PR:A6NMD2; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A6NMD2; protein.
DR Bgee; ENSG00000179938; Expressed in left testis and 94 other tissues.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 2.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome.
FT CHAIN 1..632
FT /note="Golgin subfamily A member 8J"
FT /id="PRO_0000332313"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..154
FT /evidence="ECO:0000255"
FT COILED 220..421
FT /evidence="ECO:0000255"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 71775 MW; 13C914769F4D6692 CRC64;
MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SIPEKATSGG CQPPRDSATG
FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
NNKKQKAKRV LEVQIQTLNI QKEELNTDLY HMKRSLRYFE EKSKDLAVRL QHSLQRKGEL
ESVLSNVMAT QKKKANQLSS RSKARTEWKL EQSMREEALL KVQLTQFKES FQQVQLERDE
YSEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
AVPSEVELQH LRKELERVAG ELQAQVKNNQ RISLLNQRQE ERIREQEERL RKQEERIQEQ
HKSLQQLAKP QSVFKEPNNE NKNALQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP ESREAMSSFM DHLEEKADLS ELVKKKELCF
IHHWRERCHQ KTHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGHLCEVS LTSSAQGEAR EDPLLDKPTA
QPIVQDHQEH PGLGSNCCVP FLCWAWLPRR RR
