GOG8M_HUMAN
ID GOG8M_HUMAN Reviewed; 632 AA.
AC H3BSY2; A6NCM5; F8WBD5;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Golgin subfamily A member 8M;
GN Name=GOLGA8M {ECO:0000312|HGNC:HGNC:44404};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1 {ECO:0000269|PubMed:16572171};
CC IsoId=H3BSY2-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:16572171};
CC IsoId=H3BSY2-2; Sequence=VSP_044751, VSP_044752, VSP_044753,
CC VSP_044754;
CC Name=3;
CC IsoId=H3BSY2-3; Sequence=VSP_053442, VSP_044753, VSP_044754;
CC -!- SIMILARITY: Belongs to the GOLGA8 family. {ECO:0000255}.
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DR EMBL; AC055876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS61572.1; -. [H3BSY2-1]
DR RefSeq; NP_001269397.1; NM_001282468.1. [H3BSY2-1]
DR AlphaFoldDB; H3BSY2; -.
DR SMR; H3BSY2; -.
DR BioGRID; 576013; 1.
DR STRING; 9606.ENSP00000456927; -.
DR iPTMnet; H3BSY2; -.
DR PhosphoSitePlus; H3BSY2; -.
DR BioMuta; GOLGA8M; -.
DR jPOST; H3BSY2; -.
DR MassIVE; H3BSY2; -.
DR MaxQB; H3BSY2; -.
DR PaxDb; H3BSY2; -.
DR PeptideAtlas; H3BSY2; -.
DR PRIDE; H3BSY2; -.
DR DNASU; 653720; -.
DR Ensembl; ENST00000563027.2; ENSP00000456927.1; ENSG00000188626.7. [H3BSY2-1]
DR GeneID; 653720; -.
DR KEGG; hsa:653720; -.
DR MANE-Select; ENST00000563027.2; ENSP00000456927.1; NM_001282468.3; NP_001269397.1.
DR UCSC; uc021sgq.3; human. [H3BSY2-1]
DR CTD; 653720; -.
DR GeneCards; GOLGA8M; -.
DR HGNC; HGNC:44404; GOLGA8M.
DR HPA; ENSG00000188626; Tissue enhanced (testis, thyroid gland).
DR neXtProt; NX_H3BSY2; -.
DR OpenTargets; ENSG00000188626; -.
DR VEuPathDB; HostDB:ENSG00000188626; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR HOGENOM; CLU_012403_1_2_1; -.
DR InParanoid; H3BSY2; -.
DR OMA; ERCHQNI; -.
DR OrthoDB; 358120at2759; -.
DR PhylomeDB; H3BSY2; -.
DR PathwayCommons; H3BSY2; -.
DR BioGRID-ORCS; 653720; 49 hits in 882 CRISPR screens.
DR ChiTaRS; GOLGA8M; human.
DR GenomeRNAi; 653720; -.
DR Pharos; H3BSY2; Tdark.
DR PRO; PR:H3BSY2; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; H3BSY2; protein.
DR Bgee; ENSG00000188626; Expressed in sural nerve and 90 other tissues.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 2.
PE 3: Inferred from homology;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..632
FT /note="Golgin subfamily A member 8M"
FT /id="PRO_0000420860"
FT REGION 1..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..154
FT /evidence="ECO:0000255"
FT COILED 209..421
FT /evidence="ECO:0000255"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..81
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16572171"
FT /id="VSP_044751"
FT VAR_SEQ 82..116
FT /note="RAVVLDSRSVEISQLKNTIKSLKQQKKQVEHQLEE -> MGGPVLGHWWHSG
FT GMSLAVPSLPPPGKSSVFLFLQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16572171"
FT /id="VSP_044752"
FT VAR_SEQ 104..262
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_053442"
FT VAR_SEQ 401..452
FT /note="EHLEAASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPQPMPSVPEDPES
FT -> VKESETSTPSKKGWEAGSSLWGGEVPGQRQLPAWGLVTTAPPRAVLFLASCL (in
FT isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_044753"
FT VAR_SEQ 453..632
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_044754"
SQ SEQUENCE 632 AA; 71498 MW; B2939F3C64BD3D60 CRC64;
MAEETQHNKL AAAKKKLKEY WQKNSPRVPA GANRNRKTNG SIPQTATSGG CQPPGDSATG
FHREGPTSSA TLKDLESPCQ ERAVVLDSRS VEISQLKNTI KSLKQQKKQV EHQLEEEKKA
NNKKQKAKRV LEVQLQTLNI QKEELNTDLY HMKRSLRYFE EKSKDLAVRL QHSLQRKGEL
ESVLSDVMAT QKKKANQLSS PSKAGTEWKL EQSMREEALL KVQLTQLKES FQQVQLERDE
YSEHLKGERA RWQQRMRKMS QEICTLKKEK QQDMRRVEKL ERSLSKLKNQ MAEPLPPEPP
AVPSEVELQH LRKELERVAG ELQAQVKNNQ RISLLNQRQE ERIREQEERL RKQEERIQEQ
HKSLQQLAKP QSVFEEPNNE NKSTLQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
ALPGEGHGGE HLDSEGEEAP QPMPSVPEDP ESREAMSSFM DHLEEKADLS ELVKKQELRF
IQYWQERCHQ KIHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLCEVS LTSSAQGEAR EDPLLDKPTA
QPIVQDHQEH PGLGSNCCVP FFCWAWLPRR RR
