GOG8O_HUMAN
ID GOG8O_HUMAN Reviewed; 632 AA.
AC A6NCC3; A6NHZ1; E7ENU5;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 3.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Golgin subfamily A member 8O;
GN Name=GOLGA8O;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- INTERACTION:
CC A6NCC3; PRO_0000308465 [P29991]; Xeno; NbExp=3; IntAct=EBI-8827490, EBI-8826747;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6NCC3-2; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NCC3-1; Sequence=VSP_044760, VSP_044761, VSP_044762;
CC -!- SIMILARITY: Belongs to the GOLGA6 family. {ECO:0000305}.
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DR EMBL; AC123768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59252.1; -. [A6NCC3-2]
DR RefSeq; NP_001264237.1; NM_001277308.1. [A6NCC3-2]
DR AlphaFoldDB; A6NCC3; -.
DR SMR; A6NCC3; -.
DR BioGRID; 608483; 4.
DR DIP; DIP-58933N; -.
DR IntAct; A6NCC3; 1.
DR STRING; 9606.ENSP00000423159; -.
DR iPTMnet; A6NCC3; -.
DR PhosphoSitePlus; A6NCC3; -.
DR BioMuta; GOLGA8O; -.
DR jPOST; A6NCC3; -.
DR MassIVE; A6NCC3; -.
DR MaxQB; A6NCC3; -.
DR PaxDb; A6NCC3; -.
DR PeptideAtlas; A6NCC3; -.
DR PRIDE; A6NCC3; -.
DR Antibodypedia; 73751; 18 antibodies from 2 providers.
DR DNASU; 728047; -.
DR Ensembl; ENST00000509311.7; ENSP00000423159.2; ENSG00000206127.11. [A6NCC3-2]
DR GeneID; 728047; -.
DR KEGG; hsa:728047; -.
DR MANE-Select; ENST00000509311.7; ENSP00000423159.2; NM_001277308.1; NP_001264237.1.
DR UCSC; uc031qrg.2; human. [A6NCC3-2]
DR CTD; 728047; -.
DR GeneCards; GOLGA8O; -.
DR HGNC; HGNC:44406; GOLGA8O.
DR HPA; ENSG00000206127; Group enriched (bone marrow, epididymis, testis, thyroid gland).
DR neXtProt; NX_A6NCC3; -.
DR VEuPathDB; HostDB:ENSG00000206127; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR HOGENOM; CLU_012403_1_2_1; -.
DR InParanoid; A6NCC3; -.
DR PhylomeDB; A6NCC3; -.
DR PathwayCommons; A6NCC3; -.
DR SignaLink; A6NCC3; -.
DR BioGRID-ORCS; 728047; 34 hits in 576 CRISPR screens.
DR GenomeRNAi; 728047; -.
DR Pharos; A6NCC3; Tdark.
DR PRO; PR:A6NCC3; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; A6NCC3; protein.
DR Bgee; ENSG00000206127; Expressed in right lobe of thyroid gland and 93 other tissues.
DR ExpressionAtlas; A6NCC3; baseline and differential.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..632
FT /note="Golgin subfamily A member 8O"
FT /id="PRO_0000342409"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 85..150
FT /evidence="ECO:0000255"
FT COILED 209..421
FT /evidence="ECO:0000255"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104..262
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_044760"
FT VAR_SEQ 401..456
FT /note="EHLEAASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPRPMPSVPEDPES
FT REAM -> VKETETSTPSKKGWEAGSSLLGGEVPGQRQLPAWGLVTTAPRRAVLRLFLA
FT SCL (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_044761"
FT VAR_SEQ 457..632
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_044762"
SQ SEQUENCE 632 AA; 71536 MW; D47C8F62C7FC0B4A CRC64;
MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG
FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLKQQKKQV EHQLEEEKKA
NNERQKAERE LEVQIQTLII QKEELNTDLY HMERSLRYFE EESKDLAVRL QHSLQCKGEL
ESALSAVIAT EKKKANQLSS CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE
CAEHIEGERA RWHQRMSKMS QEICTLKKEK QQDMRRVEEL ERSLSKLKNQ MAEPLPPEPP
AVPSEVELQH LRKELERVAG ELQSQVKNNQ HISLLNRRQE ERIREQEERL RKQEERLQEQ
HEKLRQLAKP QSVFEELNNE NKSTLQLEQQ VKELQEKLGE EHLEAASQQN QQLTAQLSLM
ALPGEGHGGE HLDSEGEEAP RPMPSVPEDP ESREAMSSFM DHLKEKADLS ELVKKQELRF
IQYWQERCHQ KIHHLLSEPG GRAKDAALGG GHHQAGAQGG DEGEAAGAAA DGIAAYSNYN
NGHRKFLAAA HNSADEPGPG APAPQELGAA DKHGDLREVT LTSSAQGEAR EDPLLDKPTA
QPIVQDHQEH PGLGSNCCVP LFCWAWLPRR RR
