GOG8R_HUMAN
ID GOG8R_HUMAN Reviewed; 631 AA.
AC I6L899; F5GYM5;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2012, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Golgin subfamily A member 8R;
GN Name=GOLGA8R {ECO:0000312|HGNC:HGNC:44407};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:16572171};
CC IsoId=I6L899-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:16572171};
CC IsoId=I6L899-2; Sequence=VSP_044756, VSP_044757, VSP_044758;
CC -!- SIMILARITY: Belongs to the GOLGA8 family. {ECO:0000255}.
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DR EMBL; AC019322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS61575.1; -. [I6L899-1]
DR RefSeq; NP_001269413.1; NM_001282484.1. [I6L899-1]
DR AlphaFoldDB; I6L899; -.
DR SMR; I6L899; -.
DR BioGRID; 3190633; 6.
DR IntAct; I6L899; 2.
DR iPTMnet; I6L899; -.
DR PhosphoSitePlus; I6L899; -.
DR BioMuta; GOLGA8R; -.
DR EPD; I6L899; -.
DR jPOST; I6L899; -.
DR MassIVE; I6L899; -.
DR MaxQB; I6L899; -.
DR PaxDb; I6L899; -.
DR PeptideAtlas; I6L899; -.
DR PRIDE; I6L899; -.
DR Antibodypedia; 77921; 1 antibodies from 1 providers.
DR DNASU; 101059918; -.
DR Ensembl; ENST00000327271.11; ENSP00000323217.10; ENSG00000186399.11. [I6L899-1]
DR GeneID; 101059918; -.
DR KEGG; hsa:101059918; -.
DR MANE-Select; ENST00000327271.11; ENSP00000323217.10; NM_001282484.1; NP_001269413.1.
DR UCSC; uc021shi.3; human. [I6L899-1]
DR CTD; 101059918; -.
DR GeneCards; GOLGA8R; -.
DR HGNC; HGNC:44407; GOLGA8R.
DR HPA; ENSG00000186399; Low tissue specificity.
DR neXtProt; NX_I6L899; -.
DR OpenTargets; ENSG00000186399; -.
DR VEuPathDB; HostDB:ENSG00000186399; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR HOGENOM; CLU_012403_1_2_1; -.
DR InParanoid; I6L899; -.
DR PhylomeDB; I6L899; -.
DR PathwayCommons; I6L899; -.
DR Reactome; R-HSA-9013148; CDC42 GTPase cycle.
DR Reactome; R-HSA-9013405; RHOD GTPase cycle.
DR SignaLink; I6L899; -.
DR BioGRID-ORCS; 101059918; 97 hits in 847 CRISPR screens.
DR GenomeRNAi; 101059918; -.
DR Pharos; I6L899; Tdark.
DR PRO; PR:I6L899; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; I6L899; protein.
DR Bgee; ENSG00000186399; Expressed in sural nerve and 97 other tissues.
DR GO; GO:0005801; C:cis-Golgi network; IBA:GO_Central.
DR GO; GO:0000137; C:Golgi cis cisterna; IBA:GO_Central.
DR GO; GO:0032580; C:Golgi cisterna membrane; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 2.
PE 3: Inferred from homology;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..631
FT /note="Golgin subfamily A member 8R"
FT /id="PRO_0000420862"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 85..149
FT /evidence="ECO:0000255"
FT COILED 209..247
FT /evidence="ECO:0000255"
FT COILED 303..419
FT /evidence="ECO:0000255"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 104..262
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16572171"
FT /id="VSP_044756"
FT VAR_SEQ 400..453
FT /note="EHLEVASQQNQQLTAQLSLMALPGEGHGGEHLDSEGEEAPQPMPSVPEDPES
FT RE -> VKETETSTPSKKGWEAGSSLLGGEVPGQRQLPAWGLVTTAPRRAVLRLFLTSC
FT L (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16572171"
FT /id="VSP_044757"
FT VAR_SEQ 454..631
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16572171"
FT /id="VSP_044758"
SQ SEQUENCE 631 AA; 71490 MW; 2A3B894884383C3B CRC64;
MAEETQHNKL AAAKKKLKEY WQKNRPRVPA GVNRNRKTNG SIPETATSGG CQPPGDSATG
FHREGPTSSA TLKDLESPCQ ERAVVLDSTS VKISRLKNTI KSLKQQKKQV EHQLEEEKKA
NNERQKAERV LEVQIQTLII QKEELNTDLY HMERSLRYFE EESKDLAVRL QHSLQCKGEL
ERALSAVIAT EKKKANQLSS CSKAHTEWEL EQSLQDQALL KAQLTQLKES FQQLQLERDE
CAEHIEGERA RWHQRMSKMS QEICTLKKEK QDMRWVEQLE WSLSKLKNQT AEPLPPEPPA
VPSEVELQHL RKELERVAGE LQSQVKNNQH ISLLNRRQEE RIREQEERLR KQEERLQEQH
EKLRQLAKPQ SVFEELNNEN KSTLQLEQQV KELQEKLGEE HLEVASQQNQ QLTAQLSLMA
LPGEGHGGEH LDSEGEEAPQ PMPSVPEDPE SREAMSSFMD HLKEKADLSE LLKKQELRFI
QYWQERCHQK IHHLLSEPGG RAKDAALGGG HHQAGAQGGD EGEAAGAAAD GIAAYSNYNN
GHRKFLAAAH NSADEPGPGA PAPQELGAAD KHGDLREVTL TSSAQGEARE DPLLDKPTAQ
PIVQDHQEHP GLGSNCCVPL FCWAWLPRRR R
