GOGA2_HUMAN
ID GOGA2_HUMAN Reviewed; 1002 AA.
AC Q08379; A0A0C4DGS5; Q6GRM9; Q9BRB0; Q9NYF9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 3.
DT 03-AUG-2022, entry version 199.
DE RecName: Full=Golgin subfamily A member 2;
DE AltName: Full=130 kDa cis-Golgi matrix protein {ECO:0000303|PubMed:8315394};
DE Short=GM130 {ECO:0000303|PubMed:26363069, ECO:0000303|PubMed:8315394};
DE AltName: Full=GM130 autoantigen {ECO:0000303|PubMed:8315394};
DE AltName: Full=Golgin-95 {ECO:0000303|PubMed:8315394};
GN Name=GOLGA2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND SUBCELLULAR LOCATION.
RC TISSUE=Liver;
RX PubMed=8315394; DOI=10.1084/jem.178.1.49;
RA Fritzler M.J., Hamel J.C., Ochs R.L., Chan E.K.L.;
RT "Molecular characterization of two human autoantigens: unique cDNAs
RT encoding 95- and 160-kD proteins of a putative family in the Golgi
RT complex.";
RL J. Exp. Med. 178:49-62(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Colon adenocarcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 13-1002 (ISOFORM 1), AND INTERACTION WITH
RP RAB1B.
RC TISSUE=Placenta;
RX PubMed=11306556; DOI=10.1093/embo-reports/kve065;
RA Weide T., Bayer M., Koester M., Siebrasse J.-P., Peters R., Barnekow A.;
RT "The Golgi matrix protein GM130: a specific interacting partner of the
RT small GTPase rab1b.";
RL EMBO Rep. 2:336-341(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 528-1002 (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=11781572; DOI=10.1038/ncb1201-1101;
RA Marra P., Maffucci T., Daniele T., Tullio G.D., Ikehara Y., Chan E.K.,
RA Luini A., Beznoussenko G., Mironov A., De Matteis M.A.;
RT "The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain
RT of the intermediate compartment.";
RL Nat. Cell Biol. 3:1101-1113(2001).
RN [8]
RP CLEAVAGE BY CASPASE.
RX PubMed=15003503; DOI=10.1016/j.bbrc.2004.02.015;
RA Walker A., Ward C., Sheldrake T.A., Dransfield I., Rossi A.G., Pryde J.G.,
RA Haslett C.;
RT "Golgi fragmentation during Fas-mediated apoptosis is associated with the
RT rapid loss of GM130.";
RL Biochem. Biophys. Res. Commun. 316:6-11(2004).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=16964243; DOI=10.1038/nbt1240;
RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT "A probability-based approach for high-throughput protein phosphorylation
RT analysis and site localization.";
RL Nat. Biotechnol. 24:1285-1292(2006).
RN [10]
RP FUNCTION, AND INTERACTION WITH GORASP1.
RX PubMed=16489344; DOI=10.1038/ncb1366;
RA Puthenveedu M.A., Bachert C., Puri S., Lanni F., Linstedt A.D.;
RT "GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-
RT enzyme distribution.";
RL Nat. Cell Biol. 8:238-248(2006).
RN [11]
RP FUNCTION.
RX PubMed=17314401; DOI=10.1091/mbc.e06-10-0886;
RA Marra P., Salvatore L., Mironov A. Jr., Di Campli A., Di Tullio G.,
RA Trucco A., Beznoussenko G., Mironov A., De Matteis M.A.;
RT "The biogenesis of the Golgi ribbon: the roles of membrane input from the
RT ER and of GM130.";
RL Mol. Biol. Cell 18:1595-1608(2007).
RN [12]
RP INTERACTION WITH ZFPL1.
RX PubMed=18323775; DOI=10.1038/emboj.2008.40;
RA Chiu C.-F., Ghanekar Y., Frost L., Diao A., Morrison D., McKenzie E.,
RA Lowe M.;
RT "ZFPL1, a novel ring finger protein required for cis-Golgi integrity and
RT efficient ER-to-Golgi transport.";
RL EMBO J. 27:934-947(2008).
RN [13]
RP FUNCTION, AND INTERACTION WITH GORASP1.
RX PubMed=18045989; DOI=10.1091/mbc.e07-08-0847;
RA Kodani A., Sutterlin C.;
RT "The Golgi protein GM130 regulates centrosome morphology and function.";
RL Mol. Biol. Cell 19:745-753(2008).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [15]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-438, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [16]
RP FUNCTION, AND INTERACTION WITH AKAP9.
RX PubMed=19242490; DOI=10.1038/emboj.2009.47;
RA Rivero S., Cardenas J., Bornens M., Rios R.M.;
RT "Microtubule nucleation at the cis-side of the Golgi apparatus requires
RT AKAP450 and GM130.";
RL EMBO J. 28:1016-1028(2009).
RN [17]
RP FUNCTION.
RX PubMed=19109421; DOI=10.1091/mbc.e08-08-0834;
RA Kodani A., Kristensen I., Huang L., Sutterlin C.;
RT "GM130-dependent control of Cdc42 activity at the Golgi regulates
RT centrosome organization.";
RL Mol. Biol. Cell 20:1192-1200(2009).
RN [18]
RP FUNCTION, PHOSPHORYLATION AT SER-37, METHYLATION AT ARG-18; ARG-30 AND
RP ARG-35, AND MUTAGENESIS OF ARG-18; ARG-30 AND ARG-35.
RX PubMed=20421892; DOI=10.1038/cr.2010.56;
RA Zhou Z., Sun X., Zou Z., Sun L., Zhang T., Guo S., Wen Y., Liu L., Wang Y.,
RA Qin J., Li L., Gong W., Bao S.;
RT "PRMT5 regulates Golgi apparatus structure through methylation of the
RT golgin GM130.";
RL Cell Res. 20:1023-1033(2010).
RN [19]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-953, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [20]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [21]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-438; SER-953 AND
RP SER-981, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [22]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-273; SER-690 AND SER-937, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [23]
RP FUNCTION, SUBCELLULAR LOCATION, DOMAIN, PHOSPHORYLATION, AND MUTAGENESIS OF
RP 26-LYS--LYS-49 AND SER-37.
RX PubMed=26165940; DOI=10.1016/j.cell.2015.06.014;
RA Wei J.H., Zhang Z.C., Wynn R.M., Seemann J.;
RT "GM130 regulates Golgi-derived spindle assembly by activating TPX2 and
RT capturing microtubules.";
RL Cell 162:287-299(2015).
RN [24]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [25] {ECO:0007744|PDB:4REY}
RP X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 980-1002 IN COMPLEX WITH GORASP1,
RP INTERACTION WITH GORASP1, FUNCTION, SUBUNIT, AND MUTAGENESIS OF PHE-987 AND
RP ILE-1002.
RX PubMed=26363069; DOI=10.1074/jbc.m115.657940;
RA Hu F., Shi X., Li B., Huang X., Morelli X., Shi N.;
RT "Structural basis for the interaction between the Golgi reassembly-stacking
RT protein GRASP65 and the Golgi matrix protein GM130.";
RL J. Biol. Chem. 290:26373-26382(2015).
CC -!- FUNCTION: Peripheral membrane component of the cis-Golgi stack that
CC acts as a membrane skeleton that maintains the structure of the Golgi
CC apparatus, and as a vesicle thether that facilitates vesicle fusion to
CC the Golgi membrane (Probable) (PubMed:16489344). Required for normal
CC protein transport from the endoplasmic reticulum to the Golgi apparatus
CC and the cell membrane (By similarity). Together with p115/USO1 and
CC STX5, involved in vesicle tethering and fusion at the cis-Golgi
CC membrane to maintain the stacked and inter-connected structure of the
CC Golgi apparatus. Plays a central role in mitotic Golgi disassembly:
CC phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the
CC interaction with p115/USO1, preventing tethering of COPI vesicles and
CC thereby inhibiting transport through the Golgi apparatus during mitosis
CC (By similarity). Also plays a key role in spindle pole assembly and
CC centrosome organization (PubMed:26165940). Promotes the mitotic spindle
CC pole assembly by activating the spindle assembly factor TPX2 to
CC nucleate microtubules around the Golgi and capture them to couple
CC mitotic membranes to the spindle: upon phosphorylation at the onset of
CC mitosis, GOLGA2 interacts with importin-alpha via the nuclear
CC localization signal region, leading to recruit importin-alpha to the
CC Golgi membranes and liberate the spindle assembly factor TPX2 from
CC importin-alpha. TPX2 then activates AURKA kinase and stimulates local
CC microtubule nucleation. Upon filament assembly, nascent microtubules
CC are further captured by GOLGA2, thus linking Golgi membranes to the
CC spindle (PubMed:19242490, PubMed:26165940). Regulates the meiotic
CC spindle pole assembly, probably via the same mechanism (By similarity).
CC Also regulates the centrosome organization (PubMed:18045989,
CC PubMed:19109421). Also required for the Golgi ribbon formation and
CC glycosylation of membrane and secretory proteins (PubMed:16489344,
CC PubMed:17314401). {ECO:0000250|UniProtKB:Q62839,
CC ECO:0000250|UniProtKB:Q921M4, ECO:0000269|PubMed:16489344,
CC ECO:0000269|PubMed:17314401, ECO:0000269|PubMed:18045989,
CC ECO:0000269|PubMed:19109421, ECO:0000269|PubMed:19242490,
CC ECO:0000269|PubMed:26165940, ECO:0000305|PubMed:26363069}.
CC -!- SUBUNIT: Homodimer, may assemble into homohexamers (PubMed:26363069).
CC Homotetramer; forms a parallel homotetramer with a flexible rod-like
CC structure that can give rise to I- and Y-shaped conformations (By
CC similarity). Interacts with GORASP1/GRASP65 (PubMed:16489344,
CC PubMed:18045989, PubMed:26363069). The homooligomer forms a complex
CC with GORASP1 with a 1:1 stoichiometry (By similarity). Interacts with
CC RAB1B that has been activated by GTP-binding (PubMed:11306556).
CC Interacts with p115/USO1; interaction with p115/USO1 inhibits
CC interaction with STX5 and/or RAB1B. Interacts with STX5 (By
CC similarity). Interacts with ZFPL1 (PubMed:18323775). Interacts with
CC AKAP450/AKAP9; leading to recruit AKAP450/AKAP9 to the cis-Golgi
CC (PubMed:19242490). {ECO:0000250|UniProtKB:Q62839,
CC ECO:0000269|PubMed:11306556, ECO:0000269|PubMed:16489344,
CC ECO:0000269|PubMed:18045989, ECO:0000269|PubMed:18323775,
CC ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:26363069}.
CC -!- INTERACTION:
CC Q08379; O75689: ADAP1; NbExp=3; IntAct=EBI-618309, EBI-714732;
CC Q08379; Q9UHB7: AFF4; NbExp=3; IntAct=EBI-618309, EBI-395282;
CC Q08379; Q9UHB7-2: AFF4; NbExp=3; IntAct=EBI-618309, EBI-10261324;
CC Q08379; Q99996: AKAP9; NbExp=3; IntAct=EBI-618309, EBI-1048311;
CC Q08379; Q6NS38: ALKBH2; NbExp=3; IntAct=EBI-618309, EBI-2371780;
CC Q08379; Q96Q83: ALKBH3; NbExp=5; IntAct=EBI-618309, EBI-6658697;
CC Q08379; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-618309, EBI-10187270;
CC Q08379; Q8IWG5: ANKHD1; NbExp=3; IntAct=EBI-618309, EBI-355540;
CC Q08379; X5D778: ANKRD11; NbExp=4; IntAct=EBI-618309, EBI-17183751;
CC Q08379; A1A5B0: ANKRD36; NbExp=3; IntAct=EBI-618309, EBI-14100900;
CC Q08379; Q96IX9: ANKRD36BP1; NbExp=3; IntAct=EBI-618309, EBI-744859;
CC Q08379; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-618309, EBI-11954519;
CC Q08379; P29972: AQP1; NbExp=3; IntAct=EBI-618309, EBI-745213;
CC Q08379; P53365: ARFIP2; NbExp=3; IntAct=EBI-618309, EBI-638194;
CC Q08379; Q92619: ARHGAP45; NbExp=3; IntAct=EBI-618309, EBI-2825900;
CC Q08379; Q15052: ARHGEF6; NbExp=3; IntAct=EBI-618309, EBI-1642523;
CC Q08379; Q0P5N6: ARL16; NbExp=7; IntAct=EBI-618309, EBI-10186132;
CC Q08379; P40617: ARL4A; NbExp=6; IntAct=EBI-618309, EBI-2875746;
CC Q08379; O15145: ARPC3; NbExp=6; IntAct=EBI-618309, EBI-351829;
CC Q08379; P48047: ATP5PO; NbExp=3; IntAct=EBI-618309, EBI-355815;
CC Q08379; Q8NEY4-2: ATP6V1C2; NbExp=6; IntAct=EBI-618309, EBI-10270867;
CC Q08379; Q6PJ05: ATP6V1D; NbExp=3; IntAct=EBI-618309, EBI-10253919;
CC Q08379; Q8N5Z9: ATP6V1D; NbExp=3; IntAct=EBI-618309, EBI-10266952;
CC Q08379; O75348: ATP6V1G1; NbExp=3; IntAct=EBI-618309, EBI-711802;
CC Q08379; O15169: AXIN1; NbExp=3; IntAct=EBI-618309, EBI-710484;
CC Q08379; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-618309, EBI-742750;
CC Q08379; A0AVN2: BARD1; NbExp=3; IntAct=EBI-618309, EBI-9977322;
CC Q08379; Q99728: BARD1; NbExp=6; IntAct=EBI-618309, EBI-473181;
CC Q08379; A0A0A0MR97: BAZ2B; NbExp=3; IntAct=EBI-618309, EBI-11985607;
CC Q08379; O75934: BCAS2; NbExp=9; IntAct=EBI-618309, EBI-1050106;
CC Q08379; P41182: BCL6; NbExp=5; IntAct=EBI-618309, EBI-765407;
CC Q08379; A8KA13: BCL6B; NbExp=3; IntAct=EBI-618309, EBI-10174813;
CC Q08379; Q13895: BYSL; NbExp=8; IntAct=EBI-618309, EBI-358049;
CC Q08379; Q8NA57: C12orf50; NbExp=7; IntAct=EBI-618309, EBI-10268935;
CC Q08379; Q9H6X5-2: C19orf44; NbExp=3; IntAct=EBI-618309, EBI-12061599;
CC Q08379; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-618309, EBI-8643161;
CC Q08379; Q53TS8: C2CD6; NbExp=6; IntAct=EBI-618309, EBI-739879;
CC Q08379; Q9Y376: CAB39; NbExp=3; IntAct=EBI-618309, EBI-306905;
CC Q08379; Q9Y6W3: CAPN7; NbExp=3; IntAct=EBI-618309, EBI-1765641;
CC Q08379; Q9NQ75-2: CASS4; NbExp=3; IntAct=EBI-618309, EBI-12270182;
CC Q08379; Q9HC52: CBX8; NbExp=6; IntAct=EBI-618309, EBI-712912;
CC Q08379; Q8IX12: CCAR1; NbExp=6; IntAct=EBI-618309, EBI-356265;
CC Q08379; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-618309, EBI-744556;
CC Q08379; Q8IYE1: CCDC13; NbExp=3; IntAct=EBI-618309, EBI-10961312;
CC Q08379; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-618309, EBI-10247802;
CC Q08379; Q8NCX0: CCDC150; NbExp=3; IntAct=EBI-618309, EBI-10269342;
CC Q08379; Q8NCX0-3: CCDC150; NbExp=3; IntAct=EBI-618309, EBI-12235840;
CC Q08379; Q96LX7: CCDC17; NbExp=3; IntAct=EBI-618309, EBI-719840;
CC Q08379; Q8N715: CCDC185; NbExp=3; IntAct=EBI-618309, EBI-740814;
CC Q08379; E9PSE9: CCDC198; NbExp=3; IntAct=EBI-618309, EBI-11748295;
CC Q08379; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-618309, EBI-10238351;
CC Q08379; Q6NSX1: CCDC70; NbExp=3; IntAct=EBI-618309, EBI-6873045;
CC Q08379; Q9NVE4: CCDC87; NbExp=6; IntAct=EBI-618309, EBI-749261;
CC Q08379; Q8TD31-3: CCHCR1; NbExp=8; IntAct=EBI-618309, EBI-10175300;
CC Q08379; P24863: CCNC; NbExp=3; IntAct=EBI-618309, EBI-395261;
CC Q08379; P51946: CCNH; NbExp=9; IntAct=EBI-618309, EBI-741406;
CC Q08379; Q86Y33: CDC20B; NbExp=3; IntAct=EBI-618309, EBI-10260504;
CC Q08379; Q86Y33-5: CDC20B; NbExp=3; IntAct=EBI-618309, EBI-11983537;
CC Q08379; Q16543: CDC37; NbExp=3; IntAct=EBI-618309, EBI-295634;
CC Q08379; Q99459: CDC5L; NbExp=6; IntAct=EBI-618309, EBI-374880;
CC Q08379; O00311: CDC7; NbExp=3; IntAct=EBI-618309, EBI-374980;
CC Q08379; Q6P1J9: CDC73; NbExp=12; IntAct=EBI-618309, EBI-930143;
CC Q08379; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-618309, EBI-5278764;
CC Q08379; Q07002: CDK18; NbExp=6; IntAct=EBI-618309, EBI-746238;
CC Q08379; Q8IVW4: CDKL3; NbExp=3; IntAct=EBI-618309, EBI-3919850;
CC Q08379; O76039: CDKL5; NbExp=3; IntAct=EBI-618309, EBI-1752465;
CC Q08379; P38936: CDKN1A; NbExp=3; IntAct=EBI-618309, EBI-375077;
CC Q08379; Q6IPU0: CENPP; NbExp=3; IntAct=EBI-618309, EBI-10250303;
CC Q08379; Q8IYX8: CEP57L1; NbExp=6; IntAct=EBI-618309, EBI-1104570;
CC Q08379; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-618309, EBI-10181988;
CC Q08379; Q96GE4: CEP95; NbExp=3; IntAct=EBI-618309, EBI-372775;
CC Q08379; Q9Y6H1: CHCHD2; NbExp=6; IntAct=EBI-618309, EBI-2321769;
CC Q08379; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-618309, EBI-743375;
CC Q08379; Q96RK0: CIC; NbExp=4; IntAct=EBI-618309, EBI-945857;
CC Q08379; Q9BW66: CINP; NbExp=6; IntAct=EBI-618309, EBI-739784;
CC Q08379; Q96DZ5: CLIP3; NbExp=3; IntAct=EBI-618309, EBI-12823145;
CC Q08379; P31146: CORO1A; NbExp=3; IntAct=EBI-618309, EBI-1046676;
CC Q08379; P10606: COX5B; NbExp=3; IntAct=EBI-618309, EBI-1053725;
CC Q08379; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-618309, EBI-739773;
CC Q08379; Q1MSJ5-1: CSPP1; NbExp=3; IntAct=EBI-618309, EBI-10239122;
CC Q08379; Q93034: CUL5; NbExp=3; IntAct=EBI-618309, EBI-1057139;
CC Q08379; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-618309, EBI-5453285;
CC Q08379; Q6BCY4: CYB5R2; NbExp=3; IntAct=EBI-618309, EBI-744761;
CC Q08379; Q6BCY4-2: CYB5R2; NbExp=3; IntAct=EBI-618309, EBI-12102608;
CC Q08379; Q9UER7: DAXX; NbExp=8; IntAct=EBI-618309, EBI-77321;
CC Q08379; Q9UJW0: DCTN4; NbExp=7; IntAct=EBI-618309, EBI-2134033;
CC Q08379; O43602: DCX; NbExp=4; IntAct=EBI-618309, EBI-8646694;
CC Q08379; O43602-2: DCX; NbExp=3; IntAct=EBI-618309, EBI-14148644;
CC Q08379; P26196: DDX6; NbExp=6; IntAct=EBI-618309, EBI-351257;
CC Q08379; Q05D60: DEUP1; NbExp=6; IntAct=EBI-618309, EBI-748597;
CC Q08379; O95886: DLGAP3; NbExp=3; IntAct=EBI-618309, EBI-1752541;
CC Q08379; Q15398: DLGAP5; NbExp=3; IntAct=EBI-618309, EBI-748280;
CC Q08379; Q08495: DMTN; NbExp=3; IntAct=EBI-618309, EBI-715275;
CC Q08379; Q86UW9: DTX2; NbExp=3; IntAct=EBI-618309, EBI-740376;
CC Q08379; Q5THR3-2: EFCAB6; NbExp=3; IntAct=EBI-618309, EBI-12282559;
CC Q08379; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-618309, EBI-743105;
CC Q08379; A0A0S2Z3U4: EGR2; NbExp=6; IntAct=EBI-618309, EBI-16431598;
CC Q08379; O75821: EIF3G; NbExp=3; IntAct=EBI-618309, EBI-366632;
CC Q08379; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-618309, EBI-744099;
CC Q08379; Q6UWV6: ENPP7; NbExp=3; IntAct=EBI-618309, EBI-12047821;
CC Q08379; Q56NI9: ESCO2; NbExp=3; IntAct=EBI-618309, EBI-3951849;
CC Q08379; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-618309, EBI-742102;
CC Q08379; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-618309, EBI-371876;
CC Q08379; Q9BQ89: FAM110A; NbExp=6; IntAct=EBI-618309, EBI-1752811;
CC Q08379; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-618309, EBI-741626;
CC Q08379; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-618309, EBI-11986315;
CC Q08379; Q8IXS8: FAM126B; NbExp=3; IntAct=EBI-618309, EBI-8787606;
CC Q08379; Q3B820: FAM161A; NbExp=5; IntAct=EBI-618309, EBI-719941;
CC Q08379; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-618309, EBI-7225287;
CC Q08379; Q6P9G8: FAM184A; NbExp=3; IntAct=EBI-618309, EBI-10253239;
CC Q08379; Q96PV7-2: FAM193B; NbExp=3; IntAct=EBI-618309, EBI-10292648;
CC Q08379; Q32MH5: FAM214A; NbExp=3; IntAct=EBI-618309, EBI-2866142;
CC Q08379; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-618309, EBI-745689;
CC Q08379; Q9Y247: FAM50B; NbExp=6; IntAct=EBI-618309, EBI-742802;
CC Q08379; Q86YD7: FAM90A1; NbExp=8; IntAct=EBI-618309, EBI-6658203;
CC Q08379; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-618309, EBI-10244131;
CC Q08379; Q96D16: FBXL18; NbExp=3; IntAct=EBI-618309, EBI-744419;
CC Q08379; Q9NVF7: FBXO28; NbExp=7; IntAct=EBI-618309, EBI-740282;
CC Q08379; Q6UN15: FIP1L1; NbExp=3; IntAct=EBI-618309, EBI-1021914;
CC Q08379; A4D1I3: FLJ34048; NbExp=3; IntAct=EBI-618309, EBI-10173415;
CC Q08379; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-618309, EBI-744935;
CC Q08379; Q99958: FOXC2; NbExp=3; IntAct=EBI-618309, EBI-3956892;
CC Q08379; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-618309, EBI-372506;
CC Q08379; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-618309, EBI-7960826;
CC Q08379; O95995: GAS8; NbExp=3; IntAct=EBI-618309, EBI-1052570;
CC Q08379; P23769: GATA2; NbExp=4; IntAct=EBI-618309, EBI-2806671;
CC Q08379; Q86YP4: GATAD2A; NbExp=3; IntAct=EBI-618309, EBI-726224;
CC Q08379; Q8WXI9: GATAD2B; NbExp=3; IntAct=EBI-618309, EBI-923440;
CC Q08379; Q96CN9: GCC1; NbExp=6; IntAct=EBI-618309, EBI-746252;
CC Q08379; P55040: GEM; NbExp=6; IntAct=EBI-618309, EBI-744104;
CC Q08379; P14136: GFAP; NbExp=9; IntAct=EBI-618309, EBI-744302;
CC Q08379; Q86UU5: GGN; NbExp=3; IntAct=EBI-618309, EBI-10259069;
CC Q08379; Q8IVS8: GLYCTK; NbExp=6; IntAct=EBI-618309, EBI-748515;
CC Q08379; P63218: GNG5; NbExp=3; IntAct=EBI-618309, EBI-10220734;
CC Q08379; Q9NVN8: GNL3L; NbExp=3; IntAct=EBI-618309, EBI-746682;
CC Q08379; Q08379: GOLGA2; NbExp=6; IntAct=EBI-618309, EBI-618309;
CC Q08379; Q9H8Y8: GORASP2; NbExp=7; IntAct=EBI-618309, EBI-739467;
CC Q08379; O95872: GPANK1; NbExp=4; IntAct=EBI-618309, EBI-751540;
CC Q08379; Q92917: GPKOW; NbExp=9; IntAct=EBI-618309, EBI-746309;
CC Q08379; Q14449: GRB14; NbExp=3; IntAct=EBI-618309, EBI-2680889;
CC Q08379; Q14687: GSE1; NbExp=9; IntAct=EBI-618309, EBI-372619;
CC Q08379; A4D1E9: GTPBP10; NbExp=3; IntAct=EBI-618309, EBI-5453796;
CC Q08379; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-618309, EBI-2514791;
CC Q08379; P56524: HDAC4; NbExp=3; IntAct=EBI-618309, EBI-308629;
CC Q08379; P56524-2: HDAC4; NbExp=3; IntAct=EBI-618309, EBI-11953488;
CC Q08379; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-618309, EBI-16429135;
CC Q08379; O14964: HGS; NbExp=3; IntAct=EBI-618309, EBI-740220;
CC Q08379; P09067: HOXB5; NbExp=3; IntAct=EBI-618309, EBI-3893317;
CC Q08379; P17482: HOXB9; NbExp=3; IntAct=EBI-618309, EBI-745290;
CC Q08379; P42858: HTT; NbExp=3; IntAct=EBI-618309, EBI-466029;
CC Q08379; Q96M11: HYLS1; NbExp=3; IntAct=EBI-618309, EBI-720016;
CC Q08379; Q8IY31: IFT20; NbExp=3; IntAct=EBI-618309, EBI-744203;
CC Q08379; Q9BW83: IFT27; NbExp=3; IntAct=EBI-618309, EBI-747093;
CC Q08379; Q86VF2-5: IGFN1; NbExp=3; IntAct=EBI-618309, EBI-11955401;
CC Q08379; Q14005-2: IL16; NbExp=3; IntAct=EBI-618309, EBI-17178971;
CC Q08379; Q15735: INPP5J; NbExp=6; IntAct=EBI-618309, EBI-10236940;
CC Q08379; Q8NA54: IQUB; NbExp=3; IntAct=EBI-618309, EBI-10220600;
CC Q08379; Q9H1K1: ISCU; NbExp=3; IntAct=EBI-618309, EBI-1047335;
CC Q08379; P18084: ITGB5; NbExp=3; IntAct=EBI-618309, EBI-1223434;
CC Q08379; P27987: ITPKB; NbExp=4; IntAct=EBI-618309, EBI-751388;
CC Q08379; Q63ZY3: KANK2; NbExp=7; IntAct=EBI-618309, EBI-2556193;
CC Q08379; Q7Z3B3: KANSL1; NbExp=4; IntAct=EBI-618309, EBI-740244;
CC Q08379; Q92993: KAT5; NbExp=3; IntAct=EBI-618309, EBI-399080;
CC Q08379; O60341: KDM1A; NbExp=3; IntAct=EBI-618309, EBI-710124;
CC Q08379; Q5T5P2-6: KIAA1217; NbExp=6; IntAct=EBI-618309, EBI-10188326;
CC Q08379; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-618309, EBI-2125614;
CC Q08379; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-618309, EBI-14069005;
CC Q08379; P04264: KRT1; NbExp=6; IntAct=EBI-618309, EBI-298429;
CC Q08379; P05783: KRT18; NbExp=7; IntAct=EBI-618309, EBI-297888;
CC Q08379; P02538: KRT6A; NbExp=7; IntAct=EBI-618309, EBI-702198;
CC Q08379; P04259: KRT6B; NbExp=3; IntAct=EBI-618309, EBI-740907;
CC Q08379; P48668: KRT6C; NbExp=3; IntAct=EBI-618309, EBI-2564105;
CC Q08379; O95678: KRT75; NbExp=3; IntAct=EBI-618309, EBI-2949715;
CC Q08379; Q969R5: L3MBTL2; NbExp=3; IntAct=EBI-618309, EBI-739909;
CC Q08379; Q14847: LASP1; NbExp=3; IntAct=EBI-618309, EBI-742828;
CC Q08379; Q6PJG3: LATS1; NbExp=3; IntAct=EBI-618309, EBI-10253976;
CC Q08379; Q96JN0: LCOR; NbExp=3; IntAct=EBI-618309, EBI-746045;
CC Q08379; Q13094: LCP2; NbExp=6; IntAct=EBI-618309, EBI-346946;
CC Q08379; Q96BZ8: LENG1; NbExp=8; IntAct=EBI-618309, EBI-726510;
CC Q08379; P17931: LGALS3; NbExp=3; IntAct=EBI-618309, EBI-1170392;
CC Q08379; Q6NVH9: LGALS3; NbExp=3; IntAct=EBI-618309, EBI-10187804;
CC Q08379; A0A0S2Z5S9: LHX4; NbExp=3; IntAct=EBI-618309, EBI-16429099;
CC Q08379; Q7Z4I7-5: LIMS2; NbExp=3; IntAct=EBI-618309, EBI-10257651;
CC Q08379; O14910: LIN7A; NbExp=3; IntAct=EBI-618309, EBI-2513988;
CC Q08379; Q96FE5: LINGO1; NbExp=3; IntAct=EBI-618309, EBI-719955;
CC Q08379; Q03252: LMNB2; NbExp=3; IntAct=EBI-618309, EBI-2830427;
CC Q08379; P25800: LMO1; NbExp=6; IntAct=EBI-618309, EBI-8639312;
CC Q08379; P25791: LMO2; NbExp=3; IntAct=EBI-618309, EBI-739696;
CC Q08379; Q8TAP4-4: LMO3; NbExp=5; IntAct=EBI-618309, EBI-11742507;
CC Q08379; P61968: LMO4; NbExp=6; IntAct=EBI-618309, EBI-2798728;
CC Q08379; O75608: LYPLA1; NbExp=3; IntAct=EBI-618309, EBI-1052185;
CC Q08379; Q6IAQ1: LYPLA1; NbExp=3; IntAct=EBI-618309, EBI-10249913;
CC Q08379; Q96S90: LYSMD1; NbExp=3; IntAct=EBI-618309, EBI-10293291;
CC Q08379; Q9Y586: MAB21L2; NbExp=3; IntAct=EBI-618309, EBI-6659161;
CC Q08379; P61326: MAGOH; NbExp=6; IntAct=EBI-618309, EBI-299134;
CC Q08379; Q96A72: MAGOHB; NbExp=6; IntAct=EBI-618309, EBI-746778;
CC Q08379; O95983: MBD3; NbExp=3; IntAct=EBI-618309, EBI-1783068;
CC Q08379; O95983-2: MBD3; NbExp=3; IntAct=EBI-618309, EBI-11978579;
CC Q08379; Q7L590-2: MCM10; NbExp=3; IntAct=EBI-618309, EBI-10233517;
CC Q08379; P33993: MCM7; NbExp=3; IntAct=EBI-618309, EBI-355924;
CC Q08379; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-618309, EBI-348259;
CC Q08379; P55081: MFAP1; NbExp=6; IntAct=EBI-618309, EBI-1048159;
CC Q08379; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-618309, EBI-14086479;
CC Q08379; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-618309, EBI-10172526;
CC Q08379; Q8IVT2: MISP; NbExp=3; IntAct=EBI-618309, EBI-2555085;
CC Q08379; Q9BU76: MMTAG2; NbExp=4; IntAct=EBI-618309, EBI-742459;
CC Q08379; P51948: MNAT1; NbExp=3; IntAct=EBI-618309, EBI-716139;
CC Q08379; Q9UBU8: MORF4L1; NbExp=3; IntAct=EBI-618309, EBI-399246;
CC Q08379; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-618309, EBI-10288852;
CC Q08379; Q15014: MORF4L2; NbExp=3; IntAct=EBI-618309, EBI-399257;
CC Q08379; Q6PF18: MORN3; NbExp=8; IntAct=EBI-618309, EBI-9675802;
CC Q08379; P00540: MOS; NbExp=6; IntAct=EBI-618309, EBI-1757866;
CC Q08379; Q8IXL7: MSRB3; NbExp=3; IntAct=EBI-618309, EBI-8634060;
CC Q08379; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-618309, EBI-10699187;
CC Q08379; Q499L9: MST4; NbExp=3; IntAct=EBI-618309, EBI-6137569;
CC Q08379; Q6P444: MTFR2; NbExp=3; IntAct=EBI-618309, EBI-10252703;
CC Q08379; Q9P2K5-2: MYEF2; NbExp=6; IntAct=EBI-618309, EBI-10318831;
CC Q08379; Q5VTT5-2: MYOM3; NbExp=3; IntAct=EBI-618309, EBI-12247808;
CC Q08379; P19878: NCF2; NbExp=9; IntAct=EBI-618309, EBI-489611;
CC Q08379; O14777: NDC80; NbExp=3; IntAct=EBI-618309, EBI-715849;
CC Q08379; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-618309, EBI-928842;
CC Q08379; O76041: NEBL; NbExp=4; IntAct=EBI-618309, EBI-2880203;
CC Q08379; I6L9F6: NEFL; NbExp=3; IntAct=EBI-618309, EBI-10178578;
CC Q08379; P07196: NEFL; NbExp=3; IntAct=EBI-618309, EBI-475646;
CC Q08379; Q9Y5B8: NME7; NbExp=6; IntAct=EBI-618309, EBI-744782;
CC Q08379; P29474: NOS3; NbExp=6; IntAct=EBI-618309, EBI-1391623;
CC Q08379; P48552: NRIP1; NbExp=3; IntAct=EBI-618309, EBI-746484;
CC Q08379; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-618309, EBI-12028784;
CC Q08379; Q96HA8: NTAQ1; NbExp=8; IntAct=EBI-618309, EBI-741158;
CC Q08379; O43809: NUDT21; NbExp=3; IntAct=EBI-618309, EBI-355720;
CC Q08379; Q9NPJ8: NXT2; NbExp=3; IntAct=EBI-618309, EBI-752122;
CC Q08379; Q9NPJ8-3: NXT2; NbExp=3; IntAct=EBI-618309, EBI-10698339;
CC Q08379; P00973-2: OAS1; NbExp=3; IntAct=EBI-618309, EBI-12081862;
CC Q08379; Q96NG3: ODAD4; NbExp=3; IntAct=EBI-618309, EBI-1046387;
CC Q08379; Q96F82: ORC1L; NbExp=3; IntAct=EBI-618309, EBI-10285558;
CC Q08379; Q8N7B6-2: PACRGL; NbExp=3; IntAct=EBI-618309, EBI-10694433;
CC Q08379; Q9BYG5: PARD6B; NbExp=3; IntAct=EBI-618309, EBI-295391;
CC Q08379; Q86TB9: PATL1; NbExp=6; IntAct=EBI-618309, EBI-2562092;
CC Q08379; O75928: PIAS2; NbExp=3; IntAct=EBI-618309, EBI-348555;
CC Q08379; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-618309, EBI-14066006;
CC Q08379; Q7Z2X4: PID1; NbExp=3; IntAct=EBI-618309, EBI-10256685;
CC Q08379; O00459: PIK3R2; NbExp=3; IntAct=EBI-618309, EBI-346930;
CC Q08379; Q9BSJ6: PIMREG; NbExp=3; IntAct=EBI-618309, EBI-2568609;
CC Q08379; Q13526: PIN1; NbExp=6; IntAct=EBI-618309, EBI-714158;
CC Q08379; P78337: PITX1; NbExp=3; IntAct=EBI-618309, EBI-748265;
CC Q08379; Q16512: PKN1; NbExp=6; IntAct=EBI-618309, EBI-602382;
CC Q08379; Q6P5Z2: PKN3; NbExp=3; IntAct=EBI-618309, EBI-1384335;
CC Q08379; Q13835-2: PKP1; NbExp=3; IntAct=EBI-618309, EBI-9087684;
CC Q08379; Q99959-2: PKP2; NbExp=3; IntAct=EBI-618309, EBI-10987518;
CC Q08379; Q99569: PKP4; NbExp=3; IntAct=EBI-618309, EBI-726447;
CC Q08379; Q99569-2: PKP4; NbExp=3; IntAct=EBI-618309, EBI-4324902;
CC Q08379; Q96KN8-3: PLAAT5; NbExp=6; IntAct=EBI-618309, EBI-10290304;
CC Q08379; Q9HB19: PLEKHA2; NbExp=3; IntAct=EBI-618309, EBI-4401947;
CC Q08379; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-618309, EBI-10276663;
CC Q08379; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-618309, EBI-5452779;
CC Q08379; Q96HA1-2: POM121; NbExp=3; IntAct=EBI-618309, EBI-11956563;
CC Q08379; Q15319: POU4F3; NbExp=3; IntAct=EBI-618309, EBI-12033574;
CC Q08379; Q96T49: PPP1R16B; NbExp=6; IntAct=EBI-618309, EBI-10293968;
CC Q08379; Q6NYC8: PPP1R18; NbExp=6; IntAct=EBI-618309, EBI-2557469;
CC Q08379; Q5T8A7: PPP1R26; NbExp=3; IntAct=EBI-618309, EBI-308500;
CC Q08379; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-618309, EBI-12000762;
CC Q08379; O60828: PQBP1; NbExp=6; IntAct=EBI-618309, EBI-713867;
CC Q08379; Q96QH2: PRAM1; NbExp=3; IntAct=EBI-618309, EBI-2860740;
CC Q08379; Q13131: PRKAA1; NbExp=3; IntAct=EBI-618309, EBI-1181405;
CC Q08379; P54646: PRKAA2; NbExp=3; IntAct=EBI-618309, EBI-1383852;
CC Q08379; O43741: PRKAB2; NbExp=10; IntAct=EBI-618309, EBI-1053424;
CC Q08379; Q99633: PRPF18; NbExp=3; IntAct=EBI-618309, EBI-2798416;
CC Q08379; O43395: PRPF3; NbExp=3; IntAct=EBI-618309, EBI-744322;
CC Q08379; Q8WWY3: PRPF31; NbExp=11; IntAct=EBI-618309, EBI-1567797;
CC Q08379; P25786: PSMA1; NbExp=6; IntAct=EBI-618309, EBI-359352;
CC Q08379; P25789: PSMA4; NbExp=3; IntAct=EBI-618309, EBI-359310;
CC Q08379; Q16825: PTPN21; NbExp=3; IntAct=EBI-618309, EBI-2860264;
CC Q08379; P61019: RAB2A; NbExp=7; IntAct=EBI-618309, EBI-752037;
CC Q08379; Q8WUD1: RAB2B; NbExp=6; IntAct=EBI-618309, EBI-5542466;
CC Q08379; Q14964: RAB39A; NbExp=6; IntAct=EBI-618309, EBI-3048577;
CC Q08379; Q96DA2: RAB39B; NbExp=4; IntAct=EBI-618309, EBI-9089467;
CC Q08379; Q9NS91: RAD18; NbExp=3; IntAct=EBI-618309, EBI-2339393;
CC Q08379; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-618309, EBI-744023;
CC Q08379; Q86VV4: RANBP3L; NbExp=3; IntAct=EBI-618309, EBI-12028066;
CC Q08379; Q96I25: RBM17; NbExp=8; IntAct=EBI-618309, EBI-740272;
CC Q08379; Q9NW64: RBM22; NbExp=3; IntAct=EBI-618309, EBI-2602260;
CC Q08379; P49756: RBM25; NbExp=3; IntAct=EBI-618309, EBI-2211856;
CC Q08379; Q14498-3: RBM39; NbExp=3; IntAct=EBI-618309, EBI-6654703;
CC Q08379; Q96IZ5: RBM41; NbExp=6; IntAct=EBI-618309, EBI-740773;
CC Q08379; Q9Y2P8: RCL1; NbExp=3; IntAct=EBI-618309, EBI-11026509;
CC Q08379; Q9P2K3: RCOR3; NbExp=3; IntAct=EBI-618309, EBI-743428;
CC Q08379; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-618309, EBI-1504830;
CC Q08379; P57771: RGS8; NbExp=3; IntAct=EBI-618309, EBI-10216117;
CC Q08379; P57771-2: RGS8; NbExp=3; IntAct=EBI-618309, EBI-12058229;
CC Q08379; Q9BSD3: RHNO1; NbExp=3; IntAct=EBI-618309, EBI-9658624;
CC Q08379; Q9H4E5: RHOJ; NbExp=3; IntAct=EBI-618309, EBI-6285694;
CC Q08379; Q8TCX5: RHPN1; NbExp=4; IntAct=EBI-618309, EBI-746325;
CC Q08379; Q8N443: RIBC1; NbExp=3; IntAct=EBI-618309, EBI-10265323;
CC Q08379; Q13671: RIN1; NbExp=3; IntAct=EBI-618309, EBI-366017;
CC Q08379; Q96K30: RITA1; NbExp=4; IntAct=EBI-618309, EBI-2836148;
CC Q08379; Q8IUD6: RNF135; NbExp=6; IntAct=EBI-618309, EBI-9916363;
CC Q08379; Q8NCN4: RNF169; NbExp=3; IntAct=EBI-618309, EBI-6380946;
CC Q08379; Q63HN8-6: RNF213; NbExp=3; IntAct=EBI-618309, EBI-10248548;
CC Q08379; A0A0S2Z4G9: RNF6; NbExp=6; IntAct=EBI-618309, EBI-16428950;
CC Q08379; Q9UHP6: RSPH14; NbExp=6; IntAct=EBI-618309, EBI-748350;
CC Q08379; Q7L4I2-2: RSRC2; NbExp=3; IntAct=EBI-618309, EBI-10256202;
CC Q08379; Q14D33: RTP5; NbExp=3; IntAct=EBI-618309, EBI-10217913;
CC Q08379; A0A0S2Z4M5: RXRB; NbExp=3; IntAct=EBI-618309, EBI-16436147;
CC Q08379; P28702-3: RXRB; NbExp=6; IntAct=EBI-618309, EBI-16429492;
CC Q08379; Q9UPU9: SAMD4A; NbExp=3; IntAct=EBI-618309, EBI-1047497;
CC Q08379; Q9UHR5: SAP30BP; NbExp=3; IntAct=EBI-618309, EBI-751683;
CC Q08379; Q9UPN6: SCAF8; NbExp=4; IntAct=EBI-618309, EBI-7954236;
CC Q08379; O95171: SCEL; NbExp=4; IntAct=EBI-618309, EBI-7543896;
CC Q08379; Q9BWG6: SCNM1; NbExp=5; IntAct=EBI-618309, EBI-748391;
CC Q08379; Q96T21: SECISBP2; NbExp=3; IntAct=EBI-618309, EBI-954116;
CC Q08379; P59797: SELENOV; NbExp=3; IntAct=EBI-618309, EBI-10216195;
CC Q08379; Q6NXQ0: SFRS2; NbExp=3; IntAct=EBI-618309, EBI-10251550;
CC Q08379; Q9H788: SH2D4A; NbExp=6; IntAct=EBI-618309, EBI-747035;
CC Q08379; Q9H788-2: SH2D4A; NbExp=3; IntAct=EBI-618309, EBI-10308083;
CC Q08379; Q08AM8: SH3RF2; NbExp=3; IntAct=EBI-618309, EBI-10225873;
CC Q08379; Q8TEC5: SH3RF2; NbExp=4; IntAct=EBI-618309, EBI-2130111;
CC Q08379; Q92529: SHC3; NbExp=3; IntAct=EBI-618309, EBI-79084;
CC Q08379; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-618309, EBI-12037847;
CC Q08379; O95391: SLU7; NbExp=6; IntAct=EBI-618309, EBI-750559;
CC Q08379; Q9NSI2: SLX9; NbExp=4; IntAct=EBI-618309, EBI-5457304;
CC Q08379; Q969G3: SMARCE1; NbExp=6; IntAct=EBI-618309, EBI-455078;
CC Q08379; P49901: SMCP; NbExp=3; IntAct=EBI-618309, EBI-750494;
CC Q08379; Q9H0W8: SMG9; NbExp=3; IntAct=EBI-618309, EBI-2872322;
CC Q08379; Q5SQN1: SNAP47; NbExp=3; IntAct=EBI-618309, EBI-10244848;
CC Q08379; Q96H20: SNF8; NbExp=3; IntAct=EBI-618309, EBI-747719;
CC Q08379; P14678-2: SNRPB; NbExp=3; IntAct=EBI-618309, EBI-372475;
CC Q08379; P08579: SNRPB2; NbExp=3; IntAct=EBI-618309, EBI-1053651;
CC Q08379; Q5TAL4: SNRPC; NbExp=3; IntAct=EBI-618309, EBI-10246938;
CC Q08379; Q13573: SNW1; NbExp=6; IntAct=EBI-618309, EBI-632715;
CC Q08379; Q96RF0: SNX18; NbExp=3; IntAct=EBI-618309, EBI-298169;
CC Q08379; O94875-10: SORBS2; NbExp=3; IntAct=EBI-618309, EBI-12037893;
CC Q08379; Q8TC71: SPATA18; NbExp=3; IntAct=EBI-618309, EBI-11334239;
CC Q08379; Q9UM82: SPATA2; NbExp=4; IntAct=EBI-618309, EBI-744066;
CC Q08379; Q8NHS9: SPATA22; NbExp=3; IntAct=EBI-618309, EBI-7067260;
CC Q08379; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-618309, EBI-742688;
CC Q08379; Q99469: STAC; NbExp=3; IntAct=EBI-618309, EBI-2652799;
CC Q08379; Q96FJ0: STAMBPL1; NbExp=3; IntAct=EBI-618309, EBI-745021;
CC Q08379; O00506: STK25; NbExp=16; IntAct=EBI-618309, EBI-618295;
CC Q08379; Q9P289: STK26; NbExp=6; IntAct=EBI-618309, EBI-618239;
CC Q08379; Q9H7L9: SUDS3; NbExp=3; IntAct=EBI-618309, EBI-540496;
CC Q08379; Q8IX01-3: SUGP2; NbExp=3; IntAct=EBI-618309, EBI-12317645;
CC Q08379; Q9H987-2: SYNPO2L; NbExp=3; IntAct=EBI-618309, EBI-12082116;
CC Q08379; Q9BSW7: SYT17; NbExp=3; IntAct=EBI-618309, EBI-745392;
CC Q08379; Q5T7P8-2: SYT6; NbExp=6; IntAct=EBI-618309, EBI-10246152;
CC Q08379; Q9NYJ8: TAB2; NbExp=3; IntAct=EBI-618309, EBI-358708;
CC Q08379; Q9NU19: TBC1D22B; NbExp=5; IntAct=EBI-618309, EBI-8787464;
CC Q08379; Q9Y2I9-2: TBC1D30; NbExp=3; IntAct=EBI-618309, EBI-17455779;
CC Q08379; Q32MN6: TBP; NbExp=6; IntAct=EBI-618309, EBI-10239991;
CC Q08379; Q15560: TCEA2; NbExp=6; IntAct=EBI-618309, EBI-710310;
CC Q08379; Q8N8B7: TCEANC; NbExp=3; IntAct=EBI-618309, EBI-954696;
CC Q08379; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-618309, EBI-11955057;
CC Q08379; D2IYK5: TCF19; NbExp=3; IntAct=EBI-618309, EBI-10176552;
CC Q08379; Q9Y242: TCF19; NbExp=5; IntAct=EBI-618309, EBI-7413767;
CC Q08379; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-618309, EBI-11746252;
CC Q08379; P56279: TCL1A; NbExp=8; IntAct=EBI-618309, EBI-749995;
CC Q08379; D3DUQ6: TEAD4; NbExp=3; IntAct=EBI-618309, EBI-10176734;
CC Q08379; Q15561: TEAD4; NbExp=6; IntAct=EBI-618309, EBI-747736;
CC Q08379; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-618309, EBI-11139477;
CC Q08379; A0A0S2Z5Z9: TEX9; NbExp=3; IntAct=EBI-618309, EBI-16431655;
CC Q08379; Q8N6V9: TEX9; NbExp=3; IntAct=EBI-618309, EBI-746341;
CC Q08379; Q01664: TFAP4; NbExp=6; IntAct=EBI-618309, EBI-2514218;
CC Q08379; Q9BT49: THAP7; NbExp=4; IntAct=EBI-618309, EBI-741350;
CC Q08379; Q08117: TLE5; NbExp=3; IntAct=EBI-618309, EBI-717810;
CC Q08379; Q08117-2: TLE5; NbExp=6; IntAct=EBI-618309, EBI-11741437;
CC Q08379; P09493: TPM1; NbExp=3; IntAct=EBI-618309, EBI-351158;
CC Q08379; P09493-5: TPM1; NbExp=3; IntAct=EBI-618309, EBI-10196387;
CC Q08379; P09493-10: TPM1; NbExp=3; IntAct=EBI-618309, EBI-12123928;
CC Q08379; Q8N7U7-2: TPRX1; NbExp=3; IntAct=EBI-618309, EBI-14115717;
CC Q08379; Q9ULW0: TPX2; NbExp=6; IntAct=EBI-618309, EBI-1037322;
CC Q08379; Q9BUZ4: TRAF4; NbExp=5; IntAct=EBI-618309, EBI-3650647;
CC Q08379; Q14142: TRIM14; NbExp=3; IntAct=EBI-618309, EBI-2820256;
CC Q08379; Q14134: TRIM29; NbExp=5; IntAct=EBI-618309, EBI-702370;
CC Q08379; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-618309, EBI-5235829;
CC Q08379; Q8IV54: TSC22D4; NbExp=3; IntAct=EBI-618309, EBI-10261521;
CC Q08379; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-618309, EBI-744794;
CC Q08379; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-618309, EBI-10241197;
CC Q08379; Q9NRE2: TSHZ2; NbExp=3; IntAct=EBI-618309, EBI-10687282;
CC Q08379; Q63HK5: TSHZ3; NbExp=3; IntAct=EBI-618309, EBI-9053916;
CC Q08379; Q9Y5U2: TSSC4; NbExp=3; IntAct=EBI-618309, EBI-717229;
CC Q08379; Q96PN8: TSSK3; NbExp=6; IntAct=EBI-618309, EBI-3918381;
CC Q08379; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-618309, EBI-6447954;
CC Q08379; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-618309, EBI-9090990;
CC Q08379; Q8N5M4: TTC9C; NbExp=3; IntAct=EBI-618309, EBI-2851213;
CC Q08379; P49638: TTPA; NbExp=3; IntAct=EBI-618309, EBI-10210710;
CC Q08379; P40222: TXLNA; NbExp=3; IntAct=EBI-618309, EBI-359793;
CC Q08379; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-618309, EBI-6116822;
CC Q08379; P63279: UBE2I; NbExp=4; IntAct=EBI-618309, EBI-80168;
CC Q08379; Q5VVX9: UBE2U; NbExp=4; IntAct=EBI-618309, EBI-2130181;
CC Q08379; Q15386: UBE3C; NbExp=3; IntAct=EBI-618309, EBI-1058871;
CC Q08379; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-618309, EBI-17208936;
CC Q08379; Q9Y4E8-2: USP15; NbExp=3; IntAct=EBI-618309, EBI-12041225;
CC Q08379; O75604: USP2; NbExp=6; IntAct=EBI-618309, EBI-743272;
CC Q08379; Q08E77: UTP14C; NbExp=3; IntAct=EBI-618309, EBI-10225961;
CC Q08379; Q5TAP6: UTP14C; NbExp=5; IntAct=EBI-618309, EBI-11737646;
CC Q08379; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-618309, EBI-5457544;
CC Q08379; Q14119: VEZF1; NbExp=3; IntAct=EBI-618309, EBI-11980193;
CC Q08379; Q548N1: VPS28; NbExp=3; IntAct=EBI-618309, EBI-10243107;
CC Q08379; Q9UK41: VPS28; NbExp=6; IntAct=EBI-618309, EBI-727424;
CC Q08379; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-618309, EBI-2559305;
CC Q08379; Q9Y3C0: WASHC3; NbExp=6; IntAct=EBI-618309, EBI-712969;
CC Q08379; Q9P202: WHRN; NbExp=3; IntAct=EBI-618309, EBI-310886;
CC Q08379; Q9BW85: YJU2; NbExp=8; IntAct=EBI-618309, EBI-10300345;
CC Q08379; Q05516: ZBTB16; NbExp=8; IntAct=EBI-618309, EBI-711925;
CC Q08379; Q9P1Z0: ZBTB4; NbExp=3; IntAct=EBI-618309, EBI-2564133;
CC Q08379; B2RXF5: ZBTB42; NbExp=3; IntAct=EBI-618309, EBI-12287587;
CC Q08379; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-618309, EBI-14104088;
CC Q08379; Q8IUH5: ZDHHC17; NbExp=3; IntAct=EBI-618309, EBI-524753;
CC Q08379; G3V1X1: ZFC3H1; NbExp=3; IntAct=EBI-618309, EBI-6448783;
CC Q08379; Q15911-2: ZFHX3; NbExp=3; IntAct=EBI-618309, EBI-10237226;
CC Q08379; Q6ZN57: ZFP2; NbExp=3; IntAct=EBI-618309, EBI-7236323;
CC Q08379; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-618309, EBI-8656416;
CC Q08379; A0A0S2Z6H0: ZGPAT; NbExp=6; IntAct=EBI-618309, EBI-16428984;
CC Q08379; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-618309, EBI-3439227;
CC Q08379; Q8N5A5-2: ZGPAT; NbExp=12; IntAct=EBI-618309, EBI-10183064;
CC Q08379; Q96NC0: ZMAT2; NbExp=6; IntAct=EBI-618309, EBI-2682299;
CC Q08379; Q15973: ZNF124; NbExp=3; IntAct=EBI-618309, EBI-2555767;
CC Q08379; P15622-3: ZNF250; NbExp=8; IntAct=EBI-618309, EBI-10177272;
CC Q08379; Q8ND82: ZNF280C; NbExp=3; IntAct=EBI-618309, EBI-8831272;
CC Q08379; P17036: ZNF3; NbExp=3; IntAct=EBI-618309, EBI-1640965;
CC Q08379; P13682: ZNF35; NbExp=3; IntAct=EBI-618309, EBI-11041653;
CC Q08379; Q86VK4: ZNF410; NbExp=3; IntAct=EBI-618309, EBI-720304;
CC Q08379; Q96IQ9: ZNF414; NbExp=7; IntAct=EBI-618309, EBI-744257;
CC Q08379; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-618309, EBI-740727;
CC Q08379; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-618309, EBI-11962468;
CC Q08379; Q96MX3: ZNF48; NbExp=3; IntAct=EBI-618309, EBI-12006434;
CC Q08379; Q96MN9: ZNF488; NbExp=4; IntAct=EBI-618309, EBI-948288;
CC Q08379; Q96KM6: ZNF512B; NbExp=3; IntAct=EBI-618309, EBI-1049952;
CC Q08379; Q96C55: ZNF524; NbExp=3; IntAct=EBI-618309, EBI-10283126;
CC Q08379; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-618309, EBI-10172590;
CC Q08379; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-618309, EBI-745520;
CC Q08379; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-618309, EBI-6427977;
CC Q08379; Q5T619: ZNF648; NbExp=3; IntAct=EBI-618309, EBI-11985915;
CC Q08379; A0A0S2Z5X4: ZNF688; NbExp=6; IntAct=EBI-618309, EBI-16429014;
CC Q08379; A0A0S2Z6P0: ZNF688; NbExp=3; IntAct=EBI-618309, EBI-16429989;
CC Q08379; Q6NX45: ZNF774; NbExp=7; IntAct=EBI-618309, EBI-10251462;
CC Q08379; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-618309, EBI-5667516;
CC Q08379; Q8IYH5: ZZZ3; NbExp=3; IntAct=EBI-618309, EBI-2795524;
CC Q08379; A0A384ME25; NbExp=3; IntAct=EBI-618309, EBI-10211777;
CC Q08379; A8K2R3; NbExp=3; IntAct=EBI-618309, EBI-9977437;
CC Q08379; PRO_0000449631 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-618309, EBI-25475920;
CC Q08379; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-618309, EBI-25492395;
CC Q08379; PRO_0000037946 [P29991]; Xeno; NbExp=3; IntAct=EBI-618309, EBI-8826488;
CC Q08379; PRO_0000037551 [Q9WMX2]; Xeno; NbExp=2; IntAct=EBI-618309, EBI-6863748;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000269|PubMed:11781572, ECO:0000305|PubMed:8315394}; Peripheral
CC membrane protein {ECO:0000269|PubMed:11781572}; Cytoplasmic side
CC {ECO:0000269|PubMed:11781572}. Endoplasmic reticulum-Golgi intermediate
CC compartment membrane {ECO:0000269|PubMed:11781572}; Peripheral membrane
CC protein {ECO:0000269|PubMed:11781572}; Cytoplasmic side
CC {ECO:0000269|PubMed:11781572}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000269|PubMed:26165940}. Note=Associates with the mitotic spindle
CC during mitosis (PubMed:26165940). {ECO:0000250|UniProtKB:Q62839,
CC ECO:0000269|PubMed:26165940}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q08379-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q08379-2; Sequence=VSP_007727;
CC -!- DOMAIN: Extended rod-like protein with long coiled-coil domains.
CC {ECO:0000250|UniProtKB:Q62839}.
CC -!- DOMAIN: The nuclear localization signal (cNLS) mediates interaction
CC with importin-alpha, recruiting importin-alpha to the Golgi membrane
CC and liberating TPX2. {ECO:0000269|PubMed:26165940}.
CC -!- PTM: Cleaved by caspases at the onset of apoptosis.
CC {ECO:0000269|PubMed:15003503}.
CC -!- PTM: Methylation by PRMT5 is required for Golgi ribbon formation. While
CC dimethylation at Arg-30 and Arg-35 are confirmed in vivo, it is unclear
CC whether Arg-18 is methylated in vivo. {ECO:0000269|PubMed:20421892}.
CC -!- PTM: Phosphorylated at Ser-37 by CDK1 at the onset of mitosis,
CC inhibiting the interaction with p115/USO1 and triggering Golgi
CC disassembly (PubMed:20421892, PubMed:26165940). Phosphorylated at Ser-
CC 37 in prophase as the Golgi complex starts to break down, and remains
CC phosphorylated during further breakdown and partitioning of the Golgi
CC fragments in metaphase and anaphase. In telophase, GM130 is
CC dephosphorylated by PP2A as the Golgi fragments start to reassemble (By
CC similarity). {ECO:0000250|UniProtKB:Q62839,
CC ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:26165940}.
CC -!- SIMILARITY: Belongs to the GOLGA2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH69268.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP35912.1; Type=Miscellaneous discrepancy; Note=Sequence differs from that shown after position 826 due to an internal deletion.; Evidence={ECO:0000305};
CC Sequence=EAW87762.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; L06147; AAA35920.1; -; mRNA.
DR EMBL; AL590708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87762.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC014188; AAH14188.2; -; mRNA.
DR EMBL; BC069268; AAH69268.1; ALT_INIT; mRNA.
DR EMBL; AF248953; AAF65550.1; -; mRNA.
DR EMBL; BT007248; AAP35912.1; ALT_SEQ; mRNA.
DR CCDS; CCDS6896.2; -. [Q08379-1]
DR PIR; JH0821; JH0821.
DR RefSeq; NP_004477.3; NM_004486.4. [Q08379-1]
DR PDB; 4REY; X-ray; 1.96 A; B=980-1002.
DR PDB; 6IW8; X-ray; 2.80 A; A=13-60.
DR PDB; 6IWA; X-ray; 2.40 A; A=25-52.
DR PDB; 6K06; X-ray; 1.75 A; A=13-60.
DR PDBsum; 4REY; -.
DR PDBsum; 6IW8; -.
DR PDBsum; 6IWA; -.
DR PDBsum; 6K06; -.
DR AlphaFoldDB; Q08379; -.
DR SMR; Q08379; -.
DR BioGRID; 109063; 747.
DR ComplexPortal; CPX-874; GRASP65-GM130 Golgi stacking complex.
DR CORUM; Q08379; -.
DR DIP; DIP-34271N; -.
DR IntAct; Q08379; 610.
DR MINT; Q08379; -.
DR STRING; 9606.ENSP00000416097; -.
DR MoonDB; Q08379; Predicted.
DR GlyGen; Q08379; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q08379; -.
DR PhosphoSitePlus; Q08379; -.
DR BioMuta; GOLGA2; -.
DR DMDM; 294862511; -.
DR EPD; Q08379; -.
DR jPOST; Q08379; -.
DR MassIVE; Q08379; -.
DR MaxQB; Q08379; -.
DR PaxDb; Q08379; -.
DR PeptideAtlas; Q08379; -.
DR PRIDE; Q08379; -.
DR ProteomicsDB; 58604; -. [Q08379-1]
DR ProteomicsDB; 58605; -. [Q08379-2]
DR Antibodypedia; 4216; 423 antibodies from 35 providers.
DR DNASU; 2801; -.
DR Ensembl; ENST00000421699.8; ENSP00000416097.4; ENSG00000167110.19. [Q08379-1]
DR GeneID; 2801; -.
DR KEGG; hsa:2801; -.
DR UCSC; uc011maw.2; human. [Q08379-1]
DR CTD; 2801; -.
DR DisGeNET; 2801; -.
DR GeneCards; GOLGA2; -.
DR HGNC; HGNC:4425; GOLGA2.
DR HPA; ENSG00000167110; Low tissue specificity.
DR MIM; 602580; gene.
DR neXtProt; NX_Q08379; -.
DR OpenTargets; ENSG00000167110; -.
DR PharmGKB; PA28805; -.
DR VEuPathDB; HostDB:ENSG00000167110; -.
DR eggNOG; KOG4725; Eukaryota.
DR GeneTree; ENSGT00530000062932; -.
DR InParanoid; Q08379; -.
DR OMA; QLETHVE; -.
DR OrthoDB; 358120at2759; -.
DR PhylomeDB; Q08379; -.
DR TreeFam; TF316990; -.
DR PathwayCommons; Q08379; -.
DR Reactome; R-HSA-162658; Golgi Cisternae Pericentriolar Stack Reorganization.
DR Reactome; R-HSA-204005; COPII-mediated vesicle transport.
DR Reactome; R-HSA-6807878; COPI-mediated anterograde transport.
DR Reactome; R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.
DR SignaLink; Q08379; -.
DR SIGNOR; Q08379; -.
DR BioGRID-ORCS; 2801; 43 hits in 1090 CRISPR screens.
DR ChiTaRS; GOLGA2; human.
DR GeneWiki; GOLGA2; -.
DR GenomeRNAi; 2801; -.
DR Pharos; Q08379; Tbio.
DR PRO; PR:Q08379; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q08379; protein.
DR Bgee; ENSG00000167110; Expressed in pituitary gland and 205 other tissues.
DR ExpressionAtlas; Q08379; baseline and differential.
DR Genevisible; Q08379; HS.
DR GO; GO:0005801; C:cis-Golgi network; IDA:UniProtKB.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IMP:UniProtKB.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; TAS:Reactome.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000137; C:Golgi cis cisterna; IDA:CACAO.
DR GO; GO:0032580; C:Golgi cisterna membrane; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0072686; C:mitotic spindle; IDA:UniProtKB.
DR GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0061676; F:importin-alpha family protein binding; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR GO; GO:0019905; F:syntaxin binding; IPI:UniProtKB.
DR GO; GO:0008356; P:asymmetric cell division; ISS:UniProtKB.
DR GO; GO:0007098; P:centrosome cycle; IDA:UniProtKB.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR GO; GO:0090166; P:Golgi disassembly; ISS:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0090161; P:Golgi ribbon formation; IMP:UniProtKB.
DR GO; GO:0090306; P:meiotic spindle assembly; ISS:UniProtKB.
DR GO; GO:0007020; P:microtubule nucleation; IDA:UniProtKB.
DR GO; GO:0090307; P:mitotic spindle assembly; IDA:UniProtKB.
DR GO; GO:0010507; P:negative regulation of autophagy; IMP:ParkinsonsUK-UCL.
DR GO; GO:0032091; P:negative regulation of protein binding; IDA:UniProtKB.
DR GO; GO:0060050; P:positive regulation of protein glycosylation; IMP:ParkinsonsUK-UCL.
DR GO; GO:0006486; P:protein glycosylation; IMP:UniProtKB.
DR GO; GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0051225; P:spindle assembly; IMP:UniProtKB.
DR InterPro; IPR043937; GM130_C.
DR InterPro; IPR043976; GOLGA_cons_dom.
DR InterPro; IPR024858; Golgin_A.
DR PANTHER; PTHR10881; PTHR10881; 1.
DR Pfam; PF19046; GM130_C; 1.
DR Pfam; PF15070; GOLGA2L5; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell cycle; Cell division; Coiled coil;
KW Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane; Methylation;
KW Microtubule; Mitosis; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..1002
FT /note="Golgin subfamily A member 2"
FT /id="PRO_0000190054"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1..84
FT /note="Interaction with p115/USO1"
FT /evidence="ECO:0000250|UniProtKB:Q62839"
FT REGION 694..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 992..1002
FT /note="Interaction with GORASP1/GRASP65"
FT /evidence="ECO:0000250|UniProtKB:Q62839"
FT COILED 16..892
FT /evidence="ECO:0000255"
FT MOTIF 26..49
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000269|PubMed:26165940"
FT COMPBIAS 54..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..717
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="Dimethylated arginine"
FT /evidence="ECO:0000305|PubMed:20421892"
FT MOD_RES 30
FT /note="Dimethylated arginine"
FT /evidence="ECO:0000269|PubMed:20421892"
FT MOD_RES 35
FT /note="Dimethylated arginine"
FT /evidence="ECO:0000269|PubMed:20421892"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:20421892,
FT ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:18691976"
FT MOD_RES 66
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 273
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 438
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 690
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 937
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 953
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 981
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..382
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8315394"
FT /id="VSP_007727"
FT VARIANT 902
FT /note="R -> G (in dbSNP:rs2240961)"
FT /id="VAR_033974"
FT MUTAGEN 18
FT /note="R->K: Impaired methylation; when associated with R-
FT 30 and R-35."
FT /evidence="ECO:0000269|PubMed:20421892"
FT MUTAGEN 26..49
FT /note="KKKLREYQQRNSPGVPTGAKKKKK->AAALAEYQQANSPGVPTGAAAAAA:
FT Abolishes interaction with importin-alpha."
FT /evidence="ECO:0000269|PubMed:26165940"
FT MUTAGEN 30
FT /note="R->K: Impaired methylation; when associated with R-
FT 18 and R-35."
FT /evidence="ECO:0000269|PubMed:20421892"
FT MUTAGEN 35
FT /note="R->K: Impaired methylation; when associated with R-
FT 18 and R-35."
FT /evidence="ECO:0000269|PubMed:20421892"
FT MUTAGEN 37
FT /note="S->D: Phosphomimetic mutant. Does not affect
FT interaction with importin-alpha."
FT /evidence="ECO:0000269|PubMed:26165940"
FT MUTAGEN 987
FT /note="F->A: Abolishes interaction with GORASP1. Abolishes
FT membrane clustering."
FT /evidence="ECO:0000269|PubMed:26363069"
FT MUTAGEN 1002
FT /note="I->R: Abolishes interaction with GORASP1. Abolishes
FT membrane clustering."
FT /evidence="ECO:0000269|PubMed:26363069"
FT CONFLICT 709
FT /note="Missing (in Ref. 6; AAP35912)"
FT /evidence="ECO:0000305"
FT CONFLICT 762
FT /note="R -> S (in Ref. 6; AAP35912)"
FT /evidence="ECO:0000305"
FT HELIX 29..36
FT /evidence="ECO:0007829|PDB:6K06"
SQ SEQUENCE 1002 AA; 113086 MW; BD067145C5092237 CRC64;
MWPQPRLPPR PAMSEETRQS KLAAAKKKLR EYQQRNSPGV PTGAKKKKKI KNGSNPETTT
SGGCHSPEDT PKDNAATLQP SDDTVLPGGV PSPGASLTSM AASQNHDADN VPNLMDETKT
FSSTESLRQL SQQLNGLVCE SATCVNGEGP ASSANLKDLE SRYQQLAVAL DSSYVTNKQL
NITIEKLKQQ NQEITDQLEE EKKECHQKQG ALREQLQVHI QTIGILVSEK AELQTALAHT
QHAARQKEGE SEDLASRLQY SRRRVGELER ALSAVSTQQK KADRYNKELT KERDALRLEL
YKNTQSNEDL KQEKSELEEK LRVLVTEKAG MQLNLEELQK KLEMTELLLQ QFSSRCEAPD
ANQQLQQAME ERAQLEAHLG QVMESVRQLQ MERDKYAENL KGESAMWRQR MQQMSEQVHT
LREEKECSMS RVQELETSLA ELRNQMAEPP PPEPPAGPSE VEQQLQAEAE HLRKELEGLA
GQLQAQVQDN EGLSRLNREQ EERLLELERA AELWGEQAEA RRQILETMQN DRTTISRALS
QNRELKEQLA ELQSGFVKLT NENMEITSAL QSEQHVKREL GKKLGELQEK LSELKETVEL
KSQEAQSLQQ QRDQYLGHLQ QYVAAYQQLT SEKEVLHNQL LLQTQLVDQL QQQEAQGKAV
AEMARQELQE TQERLEAATQ QNQQLRAQLS LMAHPGEGDG LDREEEEDEE EEEEEAVAVP
QPMPSIPEDL ESREAMVAFF NSAVASAEEE QARLRGQLKE QRVRCRRLAH LLASAQKEPE
AAAPAPGTGG DSVCGETHRA LQGAMEKLQS RFMELMQEKA DLKERVEELE HRCIQLSGET
DTIGEYIALY QSQRAVLKER HREKEEYISR LAQDKEEMKV KLLELQELVL RLVGDRNEWH
GRFLAAAQNP ADEPTSGAPA PQELGAANQQ GDLCEVSLAG SVEPAQGEAR EGSPRDNPTA
QQIMQLLREM QNPRERPGLG SNPCIPFFYR ADENDEVKIT VI
