GOGA4_RAT
ID GOGA4_RAT Reviewed; 2259 AA.
AC Q5U4E6;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Golgin subfamily A member 4 {ECO:0000250|UniProtKB:Q13439};
GN Name=Golga4 {ECO:0000312|EMBL:AAH85124.1, ECO:0000312|RGD:1591925};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000312|EMBL:AAH85124.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1669-2259.
RC STRAIN=Brown Norway {ECO:0000269|PubMed:15489334};
RC TISSUE=Lung {ECO:0000312|EMBL:AAH85124.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305}
RP IDENTIFICATION BY MASS SPECTROMETRY, TISSUE SPECIFICITY, AND MASS
RP SPECTROMETRY.
RC STRAIN=Holtzman {ECO:0000269|PubMed:20966424};
RC TISSUE=Sperm {ECO:0000269|PubMed:20966424};
RX PubMed=20966424; DOI=10.2164/jandrol.110.010967;
RA Suryawanshi A.R., Khan S.A., Gajbhiye R.K., Gurav M.Y., Khole V.V.;
RT "Differential proteomics leads to identification of domain specific
RT epididymal sperm proteins.";
RL J. Androl. 32:240-259(2011).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Involved in vesicular trafficking at the Golgi apparatus
CC level. May play a role in delivery of transport vesicles containing
CC GPI-linked proteins from the trans-Golgi network through its
CC interaction with MACF1. Involved in endosome-to-Golgi trafficking.
CC {ECO:0000250|UniProtKB:Q13439}.
CC -!- SUBUNIT: Homodimer. Interacts with GTP-bound ARL1 and ARL3. Interacts
CC with MACF1. Directly interacts with TBC1D23. Interacts with FAM91A1;
CC this interaction may be mediated by TBC1D23.
CC {ECO:0000250|UniProtKB:Q13439}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13439}. Golgi
CC apparatus membrane {ECO:0000250|UniProtKB:Q13439}; Peripheral membrane
CC protein {ECO:0000250|UniProtKB:Q13439}. Golgi apparatus, trans-Golgi
CC network membrane {ECO:0000250|UniProtKB:Q13439}.
CC -!- TISSUE SPECIFICITY: Expressed in the head of epididymal sperm but not
CC in testicular sperm (at protein level). {ECO:0000269|PubMed:20966424}.
CC -!- DOMAIN: Extended rod-like protein with coiled-coil domains.
CC {ECO:0000250|UniProtKB:Q13439}.
CC -!- MASS SPECTROMETRY: Mass=257406; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:20966424};
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DR EMBL; BC085124; AAH85124.1; -; mRNA.
DR AlphaFoldDB; Q5U4E6; -.
DR SMR; Q5U4E6; -.
DR STRING; 10116.ENSRNOP00000039533; -.
DR CarbonylDB; Q5U4E6; -.
DR iPTMnet; Q5U4E6; -.
DR PhosphoSitePlus; Q5U4E6; -.
DR jPOST; Q5U4E6; -.
DR PaxDb; Q5U4E6; -.
DR PeptideAtlas; Q5U4E6; -.
DR PRIDE; Q5U4E6; -.
DR UCSC; RGD:1591925; rat.
DR RGD; 1591925; Golga4.
DR eggNOG; ENOG502QTM0; Eukaryota.
DR InParanoid; Q5U4E6; -.
DR Reactome; R-RNO-6811440; Retrograde transport at the Trans-Golgi-Network.
DR PRO; PR:Q5U4E6; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000029910; Expressed in skeletal muscle tissue and 19 other tissues.
DR ExpressionAtlas; Q5U4E6; baseline and differential.
DR Genevisible; Q5U4E6; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051020; F:GTPase binding; ISO:RGD.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; ISO:RGD.
DR GO; GO:0048193; P:Golgi vesicle transport; IBA:GO_Central.
DR GO; GO:0045773; P:positive regulation of axon extension; ISO:RGD.
DR InterPro; IPR000237; GRIP_dom.
DR Pfam; PF01465; GRIP; 1.
DR SMART; SM00755; Grip; 1.
DR PROSITE; PS50913; GRIP; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..2259
FT /note="Golgin subfamily A member 4"
FT /id="PRO_0000413421"
FT DOMAIN 2199..2246
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..235
FT /note="Interaction with MACF1"
FT /evidence="ECO:0000250"
FT REGION 1932..1977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 167..2182
FT /evidence="ECO:0000255"
FT COMPBIAS 11..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 10
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13439"
FT MOD_RES 39
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q91VW5"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13439"
FT MOD_RES 104
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 111
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13439"
SQ SEQUENCE 2259 AA; 260191 MW; C1DB3ADC09BFD9CD CRC64;
MFKKLKQKIS EEQQQLQQAL APAQASSSSS TPTRTRSRTS SFTDQLDDAT PNRELLAGMV
AEPAFLSEYT IFALDPSKQP KTQTGSVSGD TQTFAQKLQL RVPSMESLFR SPIKESLFRS
SKESLVRTSS RESLNQVDLD CAVATFDPPS DMESEAEDAP WSSDSLSREQ LLQRLRRMER
SLSSYRGKYS ELVTAFQTLQ REKKKLQGIL SQSQDKSLRR ISELREELQM DQQAKRHLQE
EFDACVEEKD QYISVLQTQV SLLKQRLQNG PMSVDVPKPL PPVELQAEAH SDMEKLEEKL
EEKLEEKLEE KLEGVGEAVG GGTSAKTLEM LQQRVKRQEN LLQRCKETIG SHKEQCALLL
SEKEALQEQL EERLQELEKM KELHMAEKTK LITQLRDAKN LIEQLEQDKG MVITEAKRQM
LETLELKDDE IAQLRSHIQR MTTQGEELRE QKEKSERAAF EELEKALSTA QKTEDAQRRM
KVEMDEQIKA VERAGEEERL RLQHELSRVR QEAVSMAKKN SEQRADLQKL HAEQLASKEQ
ELSQKLESRE RELQEQMRMA LEKSRSEYLK LTQEKEQQES LALEELELQK KAILTESENK
LQGLRQEAEV HRTRIRELET SLEKSLQESR TQSERLAVHL EAEKSKHKTE LTALAEKHRT
ELEGLQQQQH SLWTERLQNL SQQHQAAVEE LREKHQQEKD ALLKEKESLF QAHIQDMNEK
TLEKLDKKQM ELESVSSELS EALKARDQLA EELSVLRGDA DQMKQALEAE LQEQRRHHQR
EVDSISGQQE IIVRRTEKAL KDEISQLGGL LKEKDEHLQE RQAQVHNLEA CLQKSAEELQ
QALAKLDLLQ AQQSTTHAQT GAYEEQLAQM QQKVSDLETE KNLLTKQVVE VETQKKRVCV
ELDAQRAQVQ QLERQRSELE DKVKSLAQLQ ESQLKNSHVE KEQAQQILTE KENVILQMRE
EQAKEIEILK QKLFSKEESI SILHEEYETK FKNQEKRMEK IKQKAKEMQE MKKKLLDQEA
KLKKELENTV LELSQKEKQF NAKILEMAQA NSAGISDTVS RLEENQRQQI ESLTGAHQRE
LDDLIESWEK KLSQQAEELR DQHEKLIEEK EQELGELKQK VLTVQSEKEE VTQEVARLTE
AVTGQDVTLA GLQGQLEQKS AAVLALSDSH AQLQSQVEKL EVDLGCALNE KLSLQEELAE
LKMLAEREKL RVSELTGKVQ AAEEELQSCK SLHEVSRKSL EDKSLNLRTL LEELASQLDR
HCERTKALLE AKTNELVCTS RDKADAILAR LSRCQRHTAT VGEALLRRMG QVSELEAQLT
QLTEEQCTLK NSFQQVTNQL EEKENQIKTM KADMEGLIAE KEALQQEGGQ QQQVASEKES
CITQLKKELS ENINAVTLLR EELSEKKSEI ASLSKQLSDV SAQLENSISP SDKAEAISAL
SKQHEEQELQ LQAQLRELSS KVDALSKEKM SALEQVDHWS NKFSEWKKKA QPRFAQYQST
IKDLQTQLDL KAKEAGEKDE QIRLLKEDLD QQNERFESLK GEMEKKECDL ETELKTRTAR
VVELEDCITQ RKKEVESLNE ALRNCSQQRD TEHSGLVQTL QRLEELGQEK DNKVREAEET
VLGLRERVSS LEAELRVVRK ELDDVNSSVK SRDGELKALE DKLELESAAK VELKRKAEQK
LAAIRKQLLS QMEAKVQQCA KDTESQLSEL RAKLQGREKQ IHILEGKLKN LASSPHPERA
VVSGSMGNVA ASPEQEAADS QECTQKACKE RVCVLQRSVI EKERLTQRLQ QGEREAAPSQ
SEVRHRELSV KLDRARAKQL EDQVLIGCLQ EELEERMKCP SILSQPMGEE TGKNNTGLKQ
NWASMVDTVQ KTLQEKELSC QALERRVREL ESDLITERDA HRLEVEKLTL KYEKSQSPQQ
EMGGKNTSVE ILEDRPEENS KSHVIESKLG TPMDGRHSDL ESKLAGSERE KQKLSKEVGR
LQKDLRALRK EHQQELDILR KECEQEAEEK LKQEQEDLEL KHSSTLKQLM REFNTQLAQK
EQELERTVQE TIDKAQEVEA ELLQSHQEET QQLHRKIAEK EDDLQRTARR YEEILDAREE
EMTAKVMDLQ TRLEELQKKY EHRLEQEESA KDSVTVLELQ TQLAQKTTLI SDSKLKEQEL
REQVHNLEDR LKSYEKSVCA AAVGAPYRGG NLYHTEVSLF GEPTEFEYLR KVLFEYMMGR
ETKTMAKVIT TVLRFPDDQA QKILEREDAR LMSWLRTSS