GOGA5_DROME
ID GOGA5_DROME Reviewed; 516 AA.
AC Q8SZ63; Q8SYC2; Q9VC88;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Golgin-84;
GN Name=Golgin84; ORFNames=CG17785;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=12429822; DOI=10.1091/mbc.e02-06-0349;
RA Gillingham A.K., Pfeifer A.C., Munro S.;
RT "CASP, the alternatively spliced product of the gene encoding the CCAAT-
RT displacement protein transcription factor, is a Golgi membrane protein
RT related to giantin.";
RL Mol. Biol. Cell 13:3761-3774(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64 AND SER-74, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: May be involved in maintaining Golgi structure and in intra-
CC Golgi transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type IV membrane protein {ECO:0000250}.
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DR EMBL; AE014297; AAF56287.2; -; Genomic_DNA.
DR EMBL; AY071091; AAL48713.1; -; mRNA.
DR EMBL; AY071645; AAL49267.1; -; mRNA.
DR RefSeq; NP_651250.2; NM_142993.3.
DR AlphaFoldDB; Q8SZ63; -.
DR SMR; Q8SZ63; -.
DR BioGRID; 67832; 11.
DR IntAct; Q8SZ63; 6.
DR STRING; 7227.FBpp0084013; -.
DR iPTMnet; Q8SZ63; -.
DR PaxDb; Q8SZ63; -.
DR PRIDE; Q8SZ63; -.
DR EnsemblMetazoa; FBtr0084629; FBpp0084013; FBgn0039188.
DR GeneID; 42905; -.
DR KEGG; dme:Dmel_CG17785; -.
DR UCSC; CG17785-RA; d. melanogaster.
DR CTD; 42905; -.
DR FlyBase; FBgn0039188; Golgin84.
DR VEuPathDB; VectorBase:FBgn0039188; -.
DR eggNOG; KOG4677; Eukaryota.
DR GeneTree; ENSGT00390000018470; -.
DR HOGENOM; CLU_022484_0_0_1; -.
DR InParanoid; Q8SZ63; -.
DR OMA; HKLQMQT; -.
DR OrthoDB; 1325011at2759; -.
DR PhylomeDB; Q8SZ63; -.
DR BioGRID-ORCS; 42905; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42905; -.
DR PRO; PR:Q8SZ63; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039188; Expressed in testis and 22 other tissues.
DR Genevisible; Q8SZ63; DM.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0031985; C:Golgi cisterna; ISS:FlyBase.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; ISS:FlyBase.
DR GO; GO:0007030; P:Golgi organization; ISS:UniProtKB.
DR GO; GO:0048193; P:Golgi vesicle transport; ISS:UniProtKB.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; IBA:GO_Central.
DR InterPro; IPR019177; Golgin_subfamily_A_member_5.
DR PANTHER; PTHR13815; PTHR13815; 2.
DR Pfam; PF09787; Golgin_A5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..516
FT /note="Golgin-84"
FT /id="PRO_0000190066"
FT TOPO_DOM 1..492
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 514..516
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 28..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 108..423
FT /evidence="ECO:0000255"
FT COMPBIAS 28..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 74
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 13
FT /note="E -> G (in Ref. 3; AAL48713)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 516 AA; 58680 MW; 19FFFF8EA6588EF2 CRC64;
MSSWITGLAD KAENILNKLD QNAATALQTE NATGSADPMR RSMTSSTQSL STSLKSTLSP
VRRSGANSSS SVKSDGGVSV VTKDMRQKMT TSASFSNSPD ISANSMDTNE LAAFKIALNE
ITAERDELRL RLEDLNNETE KFDLHQHTQV LEALVKSLSE ERDKAVHDYN EAQAANMAYV
HSISELETNL AKLQQEYISA AHKLQMQTKE TEQQRQELQE YRIKAQRALQ AKDSLIAELK
AKPTEEGADP NLVSKDSETR FLQIEHESLK QELEHANEEL QKARLQLDDY VSQERQRQVE
LSSARQREET LAKELRQARE HSVTSESDQR VLTQELASLR QQLSNQMAAA ATRLQEREQQ
LQQMRQRLSE EANTGAKSDY ETRLKALTQS LVERQSLLER VTSERNALRL QHEKAQTQLQ
QNMHLVEMES QRGSSRHTML NSTDDVKAQF PLLMHPSPFD NRVARRFKRA LRQADSMGIR
VGTFLRRYPM MRVSVIVYVA LLHLWVMFVL LSTTPN
