GOGA7_HUMAN
ID GOGA7_HUMAN Reviewed; 137 AA.
AC Q7Z5G4; D3DSX9; J3KQ24; Q96EQ4; Q9P1S0; Q9Y5U7;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Golgin subfamily A member 7;
DE AltName: Full=Golgi complex-associated protein of 16 kDa;
GN Name=GOLGA7; Synonyms=GCP16; ORFNames=HDCKB03P, HSPC041;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH GOLGA3, TISSUE
RP SPECIFICITY, PALMITOYLATION AT CYS-69 AND CYS-72, MUTAGENESIS OF CYS-24;
RP CYS-69; CYS-72 AND CYS-81, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=14522980; DOI=10.1074/jbc.m310014200;
RA Ohta E., Misumi Y., Sohda M., Fujiwara T., Yano A., Ikehara Y.;
RT "Identification and characterization of GCP16, a novel acylated Golgi
RT protein that interacts with GCP170.";
RL J. Biol. Chem. 278:51957-51967(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Zhao Z., Huang X., Li N., Zhu X., Cao X.;
RT "A novel gene from human dendritic cell.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH ZDHHC9, AND
RP FUNCTION.
RX PubMed=16000296; DOI=10.1074/jbc.m504113200;
RA Swarthout J.T., Lobo S., Farh L., Croke M.R., Greentree W.K.,
RA Deschenes R.J., Linder M.E.;
RT "DHHC9 and GCP16 constitute a human protein fatty acyltransferase with
RT specificity for H- and N-Ras.";
RL J. Biol. Chem. 280:31141-31148(2005).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: May be involved in protein transport from Golgi to cell
CC surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific
CC for HRAS and NRAS. {ECO:0000269|PubMed:14522980,
CC ECO:0000269|PubMed:16000296}.
CC -!- SUBUNIT: Interacts with GOLGA3. Interacts with ZDHHC9.
CC {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}.
CC -!- INTERACTION:
CC Q7Z5G4; P35609: ACTN2; NbExp=3; IntAct=EBI-4403685, EBI-77797;
CC Q7Z5G4; Q6L9T8: FAM72D; NbExp=3; IntAct=EBI-4403685, EBI-18397873;
CC Q7Z5G4; P22607: FGFR3; NbExp=3; IntAct=EBI-4403685, EBI-348399;
CC Q7Z5G4; Q9NS61-2: KCNIP2; NbExp=3; IntAct=EBI-4403685, EBI-1053003;
CC Q7Z5G4; Q9Y2W7: KCNIP3; NbExp=3; IntAct=EBI-4403685, EBI-751501;
CC Q7Z5G4; Q6PIL6: KCNIP4; NbExp=3; IntAct=EBI-4403685, EBI-1051469;
CC Q7Z5G4; Q14696: MESD; NbExp=3; IntAct=EBI-4403685, EBI-6165891;
CC Q7Z5G4; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-4403685, EBI-10172526;
CC Q7Z5G4; P61601: NCALD; NbExp=3; IntAct=EBI-4403685, EBI-749635;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}; Lipid-
CC anchor {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7Z5G4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z5G4-3; Sequence=VSP_046793;
CC -!- TISSUE SPECIFICITY: Expressed in all tissues except colon and thymus.
CC {ECO:0000269|PubMed:14522980, ECO:0000269|PubMed:16000296}.
CC -!- PTM: Palmitoylated on Cys-69 and Cys-72; which is required for Golgi
CC localization and interaction with GOLGA3.
CC {ECO:0000269|PubMed:14522980}.
CC -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD39919.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAF65180.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB104615; BAC82368.1; -; mRNA.
DR EMBL; AF068291; AAF65180.1; ALT_INIT; mRNA.
DR EMBL; AF125102; AAD39919.1; ALT_SEQ; mRNA.
DR EMBL; AC009630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471080; EAW63258.1; -; Genomic_DNA.
DR EMBL; CH471080; EAW63259.1; -; Genomic_DNA.
DR EMBL; BC012032; AAH12032.1; -; mRNA.
DR CCDS; CCDS34887.1; -. [Q7Z5G4-1]
DR CCDS; CCDS55226.1; -. [Q7Z5G4-3]
DR RefSeq; NP_001002296.1; NM_001002296.1. [Q7Z5G4-1]
DR RefSeq; NP_001167595.1; NM_001174124.1. [Q7Z5G4-3]
DR RefSeq; NP_057183.2; NM_016099.2. [Q7Z5G4-1]
DR AlphaFoldDB; Q7Z5G4; -.
DR SMR; Q7Z5G4; -.
DR BioGRID; 119312; 64.
DR IntAct; Q7Z5G4; 21.
DR STRING; 9606.ENSP00000350378; -.
DR TCDB; 8.A.114.1.5; the huntington-interacting protein 14 (hip14) family.
DR iPTMnet; Q7Z5G4; -.
DR PhosphoSitePlus; Q7Z5G4; -.
DR SwissPalm; Q7Z5G4; -.
DR BioMuta; GOLGA7; -.
DR DMDM; 82592879; -.
DR EPD; Q7Z5G4; -.
DR jPOST; Q7Z5G4; -.
DR MassIVE; Q7Z5G4; -.
DR MaxQB; Q7Z5G4; -.
DR PaxDb; Q7Z5G4; -.
DR PeptideAtlas; Q7Z5G4; -.
DR PRIDE; Q7Z5G4; -.
DR ProteomicsDB; 69287; -. [Q7Z5G4-1]
DR Antibodypedia; 23926; 129 antibodies from 22 providers.
DR DNASU; 51125; -.
DR Ensembl; ENST00000357743.9; ENSP00000350378.4; ENSG00000147533.18. [Q7Z5G4-1]
DR Ensembl; ENST00000405786.2; ENSP00000386030.2; ENSG00000147533.18. [Q7Z5G4-3]
DR Ensembl; ENST00000518270.5; ENSP00000429329.1; ENSG00000147533.18. [Q7Z5G4-1]
DR Ensembl; ENST00000687203.1; ENSP00000510742.1; ENSG00000147533.18. [Q7Z5G4-1]
DR GeneID; 51125; -.
DR KEGG; hsa:51125; -.
DR MANE-Select; ENST00000357743.9; ENSP00000350378.4; NM_001002296.2; NP_001002296.1.
DR UCSC; uc003xnu.4; human. [Q7Z5G4-1]
DR CTD; 51125; -.
DR DisGeNET; 51125; -.
DR GeneCards; GOLGA7; -.
DR HGNC; HGNC:24876; GOLGA7.
DR HPA; ENSG00000147533; Low tissue specificity.
DR MIM; 609453; gene.
DR neXtProt; NX_Q7Z5G4; -.
DR OpenTargets; ENSG00000147533; -.
DR PharmGKB; PA37002; -.
DR VEuPathDB; HostDB:ENSG00000147533; -.
DR eggNOG; KOG4069; Eukaryota.
DR GeneTree; ENSGT00390000000134; -.
DR HOGENOM; CLU_130071_0_1_1; -.
DR InParanoid; Q7Z5G4; -.
DR OMA; CVQTHSL; -.
DR OrthoDB; 1528169at2759; -.
DR PhylomeDB; Q7Z5G4; -.
DR TreeFam; TF313115; -.
DR PathwayCommons; Q7Z5G4; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR Reactome; R-HSA-9648002; RAS processing.
DR Reactome; R-HSA-9694548; Maturation of spike protein.
DR SignaLink; Q7Z5G4; -.
DR SIGNOR; Q7Z5G4; -.
DR BioGRID-ORCS; 51125; 22 hits in 1088 CRISPR screens.
DR ChiTaRS; GOLGA7; human.
DR GenomeRNAi; 51125; -.
DR Pharos; Q7Z5G4; Tbio.
DR PRO; PR:Q7Z5G4; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q7Z5G4; protein.
DR Bgee; ENSG00000147533; Expressed in inferior vagus X ganglion and 216 other tissues.
DR Genevisible; Q7Z5G4; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0000139; C:Golgi membrane; IDA:MGI.
DR GO; GO:0005795; C:Golgi stack; IDA:UniProtKB.
DR GO; GO:0031228; C:intrinsic component of Golgi membrane; IDA:UniProtKB.
DR GO; GO:0002178; C:palmitoyltransferase complex; IDA:UniProtKB.
DR GO; GO:1904724; C:tertiary granule lumen; TAS:Reactome.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IDA:UniProtKB.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IDA:MGI.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IDA:UniProtKB.
DR GO; GO:0050821; P:protein stabilization; IDA:UniProtKB.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR019383; Golgin_A_7/ERF4.
DR Pfam; PF10256; Erf4; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..137
FT /note="Golgin subfamily A member 7"
FT /id="PRO_0000213977"
FT LIPID 69
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000269|PubMed:14522980"
FT LIPID 72
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000269|PubMed:14522980"
FT VAR_SEQ 123..137
FT /note="IEITIYEDRGMSSGR -> FRLKLPFMKTEA (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046793"
FT MUTAGEN 24
FT /note="C->A: Slightly reduces palmitoylation."
FT /evidence="ECO:0000269|PubMed:14522980"
FT MUTAGEN 69
FT /note="C->A: Strongly reduces palmitoylation. Abolishes
FT palmitoylation and Golgi localization; when associated with
FT A-72."
FT /evidence="ECO:0000269|PubMed:14522980"
FT MUTAGEN 72
FT /note="C->A: Strongly reduces palmitoylation. Abolishes
FT palmitoylation and Golgi localization; when associated with
FT A-69."
FT /evidence="ECO:0000269|PubMed:14522980"
FT MUTAGEN 81
FT /note="C->A: Slightly reduces palmitoylation."
FT /evidence="ECO:0000269|PubMed:14522980"
FT CONFLICT 24
FT /note="C -> Y (in Ref. 2; AAF65180)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 137 AA; 15824 MW; 00280547DE3702A3 CRC64;
MRPQQAPVSG KVFIQRDYSS GTRCQFQTKF PAELENRIDR QQFEETVRTL NNLYAEAEKL
GGQSYLEGCL ACLTAYTIFL CMETHYEKVL KKVSKYIQEQ NEKIYAPQGL LLTDPIERGL
RVIEITIYED RGMSSGR
