GOGA7_MOUSE
ID GOGA7_MOUSE Reviewed; 137 AA.
AC Q91W53; Q8BN18; Q9JJE0;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Golgin subfamily A member 7;
GN Name=Golga7; ORFNames=MNCb-1213;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Bone marrow, Embryo, Head, Inner ear, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Colon, Limb, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in protein transport from Golgi to cell
CC surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific
CC for HRAS and NRAS (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with GOLGA3. Interacts with ZDHHC9 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Lipid-
CC anchor {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91W53-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91W53-2; Sequence=VSP_016281;
CC -!- PTM: Palmitoylated on Cys-69 and Cys-72; which is required for Golgi
CC localization and interaction with GOLGA3. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ERF4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA95052.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB041568; BAA95052.1; ALT_FRAME; mRNA.
DR EMBL; AK048175; BAC33266.1; -; mRNA.
DR EMBL; AK077582; BAC36875.1; -; mRNA.
DR EMBL; AK089856; BAC40977.1; -; mRNA.
DR EMBL; AK150462; BAE29580.1; -; mRNA.
DR EMBL; AK150696; BAE29775.1; -; mRNA.
DR EMBL; AK151353; BAE30329.1; -; mRNA.
DR EMBL; AK152520; BAE31280.1; -; mRNA.
DR EMBL; AK152606; BAE31353.1; -; mRNA.
DR EMBL; AK153213; BAE31811.1; -; mRNA.
DR EMBL; AK158227; BAE34413.1; -; mRNA.
DR EMBL; AK170129; BAE41583.1; -; mRNA.
DR EMBL; BC058523; AAH58523.1; -; mRNA.
DR EMBL; BC016894; AAH16894.1; -; mRNA.
DR EMBL; BC103796; AAI03797.1; -; mRNA.
DR EMBL; BC093518; AAH93518.1; -; mRNA.
DR CCDS; CCDS40297.1; -. [Q91W53-1]
DR RefSeq; NP_001035949.1; NM_001042484.1. [Q91W53-1]
DR RefSeq; NP_065610.2; NM_020585.2. [Q91W53-1]
DR AlphaFoldDB; Q91W53; -.
DR SMR; Q91W53; -.
DR BioGRID; 208294; 1.
DR STRING; 10090.ENSMUSP00000112935; -.
DR iPTMnet; Q91W53; -.
DR PhosphoSitePlus; Q91W53; -.
DR SwissPalm; Q91W53; -.
DR EPD; Q91W53; -.
DR jPOST; Q91W53; -.
DR MaxQB; Q91W53; -.
DR PaxDb; Q91W53; -.
DR PeptideAtlas; Q91W53; -.
DR PRIDE; Q91W53; -.
DR ProteomicsDB; 271249; -. [Q91W53-1]
DR ProteomicsDB; 271250; -. [Q91W53-2]
DR Antibodypedia; 23926; 129 antibodies from 22 providers.
DR DNASU; 57437; -.
DR Ensembl; ENSMUST00000051094; ENSMUSP00000062983; ENSMUSG00000015341. [Q91W53-1]
DR Ensembl; ENSMUST00000121783; ENSMUSP00000112935; ENSMUSG00000015341. [Q91W53-1]
DR GeneID; 57437; -.
DR KEGG; mmu:57437; -.
DR UCSC; uc009les.1; mouse. [Q91W53-1]
DR UCSC; uc009leu.1; mouse. [Q91W53-2]
DR CTD; 51125; -.
DR MGI; MGI:1931029; Golga7.
DR VEuPathDB; HostDB:ENSMUSG00000015341; -.
DR eggNOG; KOG4069; Eukaryota.
DR GeneTree; ENSGT00390000000134; -.
DR HOGENOM; CLU_130071_0_1_1; -.
DR InParanoid; Q91W53; -.
DR OMA; QSFEYTI; -.
DR OrthoDB; 1528169at2759; -.
DR PhylomeDB; Q91W53; -.
DR TreeFam; TF313115; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR Reactome; R-MMU-9648002; RAS processing.
DR BioGRID-ORCS; 57437; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Golga7; mouse.
DR PRO; PR:Q91W53; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q91W53; protein.
DR Bgee; ENSMUSG00000015341; Expressed in neural tube and 131 other tissues.
DR Genevisible; Q91W53; MM.
DR GO; GO:0000139; C:Golgi membrane; ISO:MGI.
DR GO; GO:0005795; C:Golgi stack; ISS:CAFA.
DR GO; GO:0031228; C:intrinsic component of Golgi membrane; ISS:CAFA.
DR GO; GO:0002178; C:palmitoyltransferase complex; ISS:CAFA.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; ISS:CAFA.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; ISO:MGI.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; ISS:CAFA.
DR GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR019383; Golgin_A_7/ERF4.
DR Pfam; PF10256; Erf4; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Lipoprotein; Membrane; Palmitate;
KW Reference proteome.
FT CHAIN 1..137
FT /note="Golgin subfamily A member 7"
FT /id="PRO_0000213978"
FT LIPID 69
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 72
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 90..137
FT /note="LKKVSKYIQEQNEKIYAPQGLLLTDPIERGLRVIEITIYEDRGVSSGR ->
FT WLHLCSVKSLNTMKEDKSLHINSSFKLEKPLYNSDFVIALTVQSTQKWVLSVCEIGQHV
FT QVCLG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016281"
SQ SEQUENCE 137 AA; 15792 MW; 00280547CA6702A3 CRC64;
MRPQQAPVSG KVFIQRDYSS GTRCQFQTKF PAELENRIDR QQFEETVRTL NNLYAEAEKL
GGQSYLEGCL ACLTAYTIFL CMETHYEKVL KKVSKYIQEQ NEKIYAPQGL LLTDPIERGL
RVIEITIYED RGVSSGR
