GOGC1_ARATH
ID GOGC1_ARATH Reviewed; 707 AA.
AC Q8S8N9; B0F9L5; Q0WNI1; Q6NMI2;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Golgin candidate 1;
DE Short=AtGC1;
DE AltName: Full=Golgin-84;
GN Name=GC1; OrderedLocusNames=At2g19950; ORFNames=F6F22.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, GENE FAMILY,
RP AND NOMENCLATURE.
RX PubMed=18182439; DOI=10.1093/jxb/erm304;
RA Latijnhouwers M., Gillespie T., Boevink P., Kriechbaumer V., Hawes C.,
RA Carvalho C.M.;
RT "Localization and domain characterization of Arabidopsis golgin
RT candidates.";
RL J. Exp. Bot. 58:4373-4386(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION.
RX PubMed=12429822; DOI=10.1091/mbc.e02-06-0349;
RA Gillingham A.K., Pfeifer A.C., Munro S.;
RT "CASP, the alternatively spliced product of the gene encoding the CCAAT-
RT displacement protein transcription factor, is a Golgi membrane protein
RT related to giantin.";
RL Mol. Biol. Cell 13:3761-3774(2002).
CC -!- FUNCTION: Golgi matrix protein playing a role in tethering of vesicles
CC to Golgi membranes and in maintaining the overall structure of the
CC Golgi apparatus.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:18182439}; Single-pass type II membrane protein
CC {ECO:0000269|PubMed:18182439}. Note=Probably located to cisternal rims
CC of cis or medial Golgi.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8S8N9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8S8N9-2; Sequence=VSP_035177;
CC -!- DOMAIN: The C-terminal domain (558-707) is necessary and sufficient for
CC Golgi targeting.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM15012.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; EU249328; ABY67248.1; -; mRNA.
DR EMBL; AC005169; AAM15012.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06947.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06948.1; -; Genomic_DNA.
DR EMBL; BT011678; AAS49041.1; -; mRNA.
DR EMBL; AK229460; BAF01318.1; -; mRNA.
DR PIR; B84583; B84583.
DR RefSeq; NP_001189556.1; NM_001202627.2. [Q8S8N9-2]
DR RefSeq; NP_179585.3; NM_127553.3. [Q8S8N9-1]
DR AlphaFoldDB; Q8S8N9; -.
DR SMR; Q8S8N9; -.
DR STRING; 3702.AT2G19950.2; -.
DR TCDB; 9.B.392.2.2; the golgi apparatus golgin (golgin) family.
DR iPTMnet; Q8S8N9; -.
DR PaxDb; Q8S8N9; -.
DR PRIDE; Q8S8N9; -.
DR ProteomicsDB; 247017; -. [Q8S8N9-1]
DR EnsemblPlants; AT2G19950.1; AT2G19950.1; AT2G19950. [Q8S8N9-1]
DR EnsemblPlants; AT2G19950.2; AT2G19950.2; AT2G19950. [Q8S8N9-2]
DR GeneID; 816514; -.
DR Gramene; AT2G19950.1; AT2G19950.1; AT2G19950. [Q8S8N9-1]
DR Gramene; AT2G19950.2; AT2G19950.2; AT2G19950. [Q8S8N9-2]
DR KEGG; ath:AT2G19950; -.
DR Araport; AT2G19950; -.
DR TAIR; locus:2051930; AT2G19950.
DR eggNOG; ENOG502QT7E; Eukaryota.
DR HOGENOM; CLU_405131_0_0_1; -.
DR InParanoid; Q8S8N9; -.
DR OMA; ILSFHTS; -.
DR PhylomeDB; Q8S8N9; -.
DR PRO; PR:Q8S8N9; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8S8N9; baseline and differential.
DR Genevisible; Q8S8N9; AT.
DR GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
DR GO; GO:0031985; C:Golgi cisterna; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; IBA:GO_Central.
DR InterPro; IPR019177; Golgin_subfamily_A_member_5.
DR PANTHER; PTHR13815; PTHR13815; 1.
DR Pfam; PF09787; Golgin_A5; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Golgi apparatus; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..707
FT /note="Golgin candidate 1"
FT /id="PRO_0000190068"
FT TOPO_DOM 1..664
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 665..685
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 686..707
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 22..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 287..424
FT /evidence="ECO:0000255"
FT COILED 452..608
FT /evidence="ECO:0000255"
FT COMPBIAS 66..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 53
FT /note="K -> KARQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18182439"
FT /id="VSP_035177"
FT CONFLICT 636
FT /note="A -> D (in Ref. 1; ABY67248)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 707 AA; 79180 MW; 8C2000DD18CE8D5C CRC64;
MASWLKAAED LFEVVDRRAK SVVEDLSEEQ NDLQLPASGR KGSQGKRTSS KKKKLVKEES
SNKRDSSGDQ SGPGVSQSEV PPSKSSVSTD ETSSSGPVLL TREIHPTDAD VQSVLSLPLS
VADTKSDDAA VVAQESIVDG DRSESKHADG DIPNDSLVQP SPSLPDKEIE VVVSENLMDA
PKNGTQRELD DSSKRDVENL DSVVHAPSVN EGNVAQSTGD EVKVGTSINL EKEQEPKVPV
TSTNLKREQD RRADTTSMKI QDQLEEAQGL LKATVSTGQS KEARLARVCA GLSSRLQEIK
AENAQLEELL TAEQELTKSY EASIRHLQKD LSAAKSEVTK VESSMVEALA AKNSEIETLV
SAMDALKNQA ALNEGKLSSL QGDMESIMRN RELAETRMMQ ALREELATTE RRAEEERSAH
NATKMAAMER ERELEHRAVD ASTALVRIQR IADERTAKVA DFEQKVALLE AECTSLNQEL
QDMEVRARRG QKKAPDEANQ VIQIQAWQDE VDRARQGQRD AEEKLSLMEA EMQKLRVEMA
AMKRDAEHYS RQEHTELEKR YRELTDLLYY KQTQLETMAS EKAAAEFQLE KEVKRLHEAQ
VEVEKSRVSR RASATWEEDS EIKTLEPLPL YHRHMATAST QLQNAVKLLD SGAVRATRFL
WRYPIARMFL LFYLVFVHLF LMYLIHRLQE QAEAQEVAAM TNNVFRL
