GOGC2_ARATH
ID GOGC2_ARATH Reviewed; 668 AA.
AC B0F9L7; Q9LM30; Q9LMR9;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Golgin candidate 2;
DE Short=AtGC2;
GN Name=GC2; OrderedLocusNames=At1g18190; ORFNames=T10F20.19, T10O22.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=18182439; DOI=10.1093/jxb/erm304;
RA Latijnhouwers M., Gillespie T., Boevink P., Kriechbaumer V., Hawes C.,
RA Carvalho C.M.;
RT "Localization and domain characterization of Arabidopsis golgin
RT candidates.";
RL J. Exp. Bot. 58:4373-4386(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: Golgi matrix protein playing a role in tethering of vesicles
CC to Golgi membranes and in maintaining the overall structure of the
CC Golgi apparatus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:18182439}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:18182439}. Note=Probably located to cisternal rims
CC of cis or medial Golgi.
CC -!- DOMAIN: The C-terminal domain (508-668) is necessary and sufficient for
CC Golgi targeting.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF78387.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAF97835.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; EU249330; ABY67250.1; -; mRNA.
DR EMBL; AC034107; AAF97835.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC069551; AAF78387.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29685.1; -; Genomic_DNA.
DR RefSeq; NP_173257.2; NM_101679.4.
DR AlphaFoldDB; B0F9L7; -.
DR SMR; B0F9L7; -.
DR STRING; 3702.AT1G18190.1; -.
DR iPTMnet; B0F9L7; -.
DR PaxDb; B0F9L7; -.
DR PRIDE; B0F9L7; -.
DR ProteomicsDB; 248438; -.
DR EnsemblPlants; AT1G18190.1; AT1G18190.1; AT1G18190.
DR GeneID; 838398; -.
DR Gramene; AT1G18190.1; AT1G18190.1; AT1G18190.
DR KEGG; ath:AT1G18190; -.
DR Araport; AT1G18190; -.
DR TAIR; locus:2194075; AT1G18190.
DR eggNOG; ENOG502QVAS; Eukaryota.
DR HOGENOM; CLU_020951_1_0_1; -.
DR InParanoid; B0F9L7; -.
DR OMA; TTMMETM; -.
DR OrthoDB; 1090159at2759; -.
DR PhylomeDB; B0F9L7; -.
DR PRO; PR:B0F9L7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; B0F9L7; baseline and differential.
DR Genevisible; B0F9L7; AT.
DR GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
DR GO; GO:0031985; C:Golgi cisterna; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; IBA:GO_Central.
DR InterPro; IPR019177; Golgin_subfamily_A_member_5.
DR PANTHER; PTHR13815; PTHR13815; 1.
DR Pfam; PF09787; Golgin_A5; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..668
FT /note="Golgin candidate 2"
FT /id="PRO_0000348536"
FT TRANSMEM 594..614
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 622..642
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 22..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 331..539
FT /evidence="ECO:0000255"
FT COMPBIAS 24..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 74787 MW; 67121F104479FD6C CRC64;
MANWISSKLK AAETILQQLD QQAADSLRKD EKSETHDEVF ETSPKSGSSP VSLKDQLRKK
TYEGSDSGSG SQRNSTEQKP SYLSSSKKVR KPDQSHERTS APSQSLTQDN TKLTDNDWTE
LLSTPNQRTS TSTSRSPGGT SAIRGLKKDG KRHGNLGKNP LVSDGKKSSS SNVVNSRGRP
QKQTNKEPSD KEVSSPSDAD MKNRNAPRDI FVNSTHKESE KDVSGKTPPL DDSRRSANET
LPRETSPSVG KRDGRESRRS SVWGKQVREE VSQSNVSDGL TRKESSLSSD ESESDYESDS
STDSERERQR EERRRRRERV FAEKVATKAV AVIKERENMV ARLEGEKLSL EKIVEERAKQ
QAQEAAELQT NMMETLEAAD LEKQKHNNTR MEVLTRLAGL EAENAELTRS LAAGQKKLET
QIDQVAVLKQ QVELKESTLE ELKRNTFNIG GRGTTLKQLD TSRGDKFEHQ MLEAEISLLT
DKIGRLQDKA TKLEADIEMM RKELEEPTEV EIELKRRLNQ LTDHLIQKQS QVEALSSEKA
TILFRIEAVS RLIEENKGMS ATEASSQDLE AGDWELSGSK FKPAFQDKIR SGKKHLGWLV
MQLNAIFISG TVFLRRNPTA KIWAVVYLVC LHLWVLYILL SHSDASSSGE LRSGAVISLE
NFSNSSLQ
