ID   GOLI4_XENTR             Reviewed;         638 AA.
AC   Q08D19;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Golgi integral membrane protein 4;
DE   AltName: Full=Golgi phosphoprotein 4;
GN   Name=golim4; Synonyms=golph4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Lung;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in endosome to Golgi protein trafficking.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane
CC       {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
CC       Endosome membrane {ECO:0000250}; Single-pass type II membrane protein
CC       {ECO:0000250}. Note=Localizes to cis and medial Golgi cisternae.
CC       Probably cycles between early Golgi and distal compartments like
CC       endosome (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GOLIM4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI23988.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC123987; AAI23988.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001072668.2; NM_001079200.1.
DR   AlphaFoldDB; Q08D19; -.
DR   SMR; Q08D19; -.
DR   STRING; 8364.ENSXETP00000049430; -.
DR   DNASU; 780125; -.
DR   GeneID; 780125; -.
DR   KEGG; xtr:780125; -.
DR   CTD; 27333; -.
DR   Xenbase; XB-GENE-980151; golim4.
DR   InParanoid; Q08D19; -.
DR   OrthoDB; 619770at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   InterPro; IPR042336; GOLIM4.
DR   PANTHER; PTHR22909; PTHR22909; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Golgi apparatus; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..638
FT                   /note="Golgi integral membrane protein 4"
FT                   /id="PRO_0000285100"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..638
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          38..107
FT                   /note="Golgi targeting"
FT                   /evidence="ECO:0000250"
FT   REGION          80..175
FT                   /note="Endosome targeting"
FT                   /evidence="ECO:0000250"
FT   REGION          176..220
FT                   /note="Golgi targeting"
FT                   /evidence="ECO:0000250"
FT   REGION          217..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          66..216
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        227..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        302..351
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..389
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..494
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        529..549
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        550..564
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        591..612
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  74883 MW;  6CD818896B61F0D5 CRC64;
     MGNGMCSRRQ KRIFQALACL AVAIGFVYGA MLNYHLQNDL KKAEAVALKY QQHHESMSAQ
     LQVVYEHRSR LEKSLQKERL EHKKAKEDFL VYKLEAQETL NKGRQDSNNR YNALGVQHEM
     LKSQHEELRK QHNELQGEHQ KLGEDLTRTY SNHKEKYLLL QQEKEQEHSK LKESIYNLRE
     ENKQLRKAHQ DVHLQLQDVK SQVEEYVQLK KALNKMSSLR QPEKDTVPIG RNNSPTIAPT
     QEHATEQELM TNVQTRQVVD HDIIIRSSTA ANDEAVHLNR VKTNLDKPDE DTVPLPEAEA
     ATEHPVEVEE EHKKELEEEE MEQVGKPERL VEEQDQVQEE QEQHKPEEDD ALEGNNEEQK
     EEETNNMQGN KHTERDPTLK PHSKYKSAYE EQLEQQQLAA RQMEEARHLK EQQDLLHQQR
     LKEHILRQQQ LHENDIELQR QNKYKEEQLA EKLRKQAEYE NVDHDIVQGE EEQPIQQEEA
     AYERDNHQDE AEDVDAANNA NEEQALDQEA ESREGQEKAA AEDVNPADDP NNQGEDEFEE
     AEQEREENLP DENEAQRQQQ EHPEVQEHLA MAGNPDQQED NIDQQYQEEE EEERQIGAER
     EPDAQQEENK ERNEENYEEE EEEEDGAAGV KNKRRAEM