ID   GOLM2_BOVIN             Reviewed;         380 AA.
AC   A2VE10;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Protein GOLM2 {ECO:0000305};
DE   AltName: Full=Cancer susceptibility candidate gene 4 protein homolog;
DE            Short=CASC4;
DE   AltName: Full=Golgi membrane protein 2 {ECO:0000305};
GN   Name=GOLM2; Synonyms=CASC4 {ECO:0000250|UniProtKB:Q6P4E1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GOLM family. {ECO:0000305}.
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DR   EMBL; BC133511; AAI33512.1; -; mRNA.
DR   RefSeq; NP_001075206.1; NM_001081737.2.
DR   AlphaFoldDB; A2VE10; -.
DR   SMR; A2VE10; -.
DR   STRING; 9913.ENSBTAP00000048585; -.
DR   PaxDb; A2VE10; -.
DR   PRIDE; A2VE10; -.
DR   Ensembl; ENSBTAT00000057473; ENSBTAP00000048585; ENSBTAG00000012545.
DR   GeneID; 540780; -.
DR   KEGG; bta:540780; -.
DR   CTD; 113201; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012545; -.
DR   VGNC; VGNC:84818; GOLM2.
DR   eggNOG; ENOG502QTYH; Eukaryota.
DR   GeneTree; ENSGT00530000063675; -.
DR   HOGENOM; CLU_052047_1_0_1; -.
DR   InParanoid; A2VE10; -.
DR   OrthoDB; 913812at2759; -.
DR   TreeFam; TF331127; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000012545; Expressed in occipital lobe and 108 other tissues.
DR   ExpressionAtlas; A2VE10; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026141; CASC4.
DR   InterPro; IPR026139; GOLM1/CASC4.
DR   PANTHER; PTHR15896; PTHR15896; 2.
DR   PANTHER; PTHR15896:SF7; PTHR15896:SF7; 2.
DR   PRINTS; PR02084; GOLM1CASC4.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Membrane; Phosphoprotein; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..380
FT                   /note="Protein GOLM2"
FT                   /id="PRO_0000291842"
FT   TOPO_DOM        1..14
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..380
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          192..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          35..195
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        192..208
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        228..245
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..325
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
FT   MOD_RES         233
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
FT   MOD_RES         275
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
SQ   SEQUENCE   380 AA;  43199 MW;  DE919BD30261474F CRC64;
     MVGFGANRRA GRLPSLVLAV LLVVIAVLAF NYWSISSRHV LLQEEVAELQ GQVQRTEVAR
     GRLEKRNSDL LLLVDSHKKQ IDQKEADYGR LSSRLQAREG LGKRCEDDKV KLQNNISYQM
     ADIHHLKEQL AELRQEFLRQ EDQLQDYRKN NTYLVKRLEY ESFQCGQQIK ELRAQHEENI
     KKLADQFLQE QKQEAHKFES KGGNELDTDN HAVPKNIPEV AENGAGKNEE PSSHHIPHGK
     EQIKRGGDAG MPGIEENDLA KAEDVPVALK KPPVSFSQYE SHQVISHLPT GQPLSPNMVP
     DSHINHNGNS RTSKQNPSNP LQRLIPGPNL ENEPRIQAEV LKQATKDRAG DFHKLKQNDE
     ERELQMDPAD YGKQRFNDAL