ID   GOLM2_CHICK             Reviewed;         375 AA.
AC   Q5ZKQ5;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein GOLM2 {ECO:0000305};
DE   AltName: Full=Cancer susceptibility candidate gene 4 protein homolog;
DE            Short=CASC4;
DE   AltName: Full=Golgi membrane protein 2 {ECO:0000305};
GN   Name=GOLM2; Synonyms=CASC4; ORFNames=RCJMB04_9k24;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GOLM family. {ECO:0000305}.
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DR   EMBL; AJ720029; CAG31688.1; -; mRNA.
DR   RefSeq; NP_001025727.1; NM_001030556.1.
DR   AlphaFoldDB; Q5ZKQ5; -.
DR   SMR; Q5ZKQ5; -.
DR   STRING; 9031.ENSGALP00000013350; -.
DR   PaxDb; Q5ZKQ5; -.
DR   PRIDE; Q5ZKQ5; -.
DR   GeneID; 415575; -.
DR   KEGG; gga:415575; -.
DR   CTD; 415575; -.
DR   VEuPathDB; HostDB:geneid_415575; -.
DR   eggNOG; ENOG502QTYH; Eukaryota.
DR   InParanoid; Q5ZKQ5; -.
DR   PhylomeDB; Q5ZKQ5; -.
DR   PRO; PR:Q5ZKQ5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026141; CASC4.
DR   InterPro; IPR026139; GOLM1/CASC4.
DR   PANTHER; PTHR15896; PTHR15896; 1.
DR   PANTHER; PTHR15896:SF7; PTHR15896:SF7; 1.
DR   PRINTS; PR02084; GOLM1CASC4.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..375
FT                   /note="Protein GOLM2"
FT                   /id="PRO_0000291846"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..375
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          81..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          193..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          34..198
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        193..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..363
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   375 AA;  42497 MW;  FB8C8BD35C61F368 CRC64;
     MVGFGANRRG GRLPSFLLAA LLLVIAVLAF NCWNAASRQA VLREELAELQ SQAKRTEVAR
     GRLEKRNSDL LGRVDSHRKQ LEQKEADYSQ LSSQLQARDG QVKRCEDSRV KLQNNISYQM
     ADIHRLKEQL AELRQEFIRQ EDQLHEYKKN NTYLTRRLEY DSLQCGQQIK EMRIQHEENI
     KKLMDQIVRE QKATQRIQSS KDAEVNPNGD NQPISKTVPE MEVKNAENNE LPSDRVVNGK
     EKVKPGGDAG MPEIEDNDPA KAEDTPTAPR SDNHHQADVN LPTEQPHAPN LAPGLHGDSD
     GNADIAKEIP PNSLQHLNFG ENMDSQNENK IEADHLKLQK GRAVGLQKMK QNDEERDLQN
     DLVDYSKPRF GDGVL