ID   GOLM2_PONAB             Reviewed;         436 AA.
AC   Q5R5X4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Protein GOLM2 {ECO:0000305};
DE   AltName: Full=Cancer susceptibility candidate gene 4 protein homolog;
DE            Short=CASC4;
DE   AltName: Full=Golgi membrane protein 2 {ECO:0000305};
GN   Name=GOLM2; Synonyms=CASC4 {ECO:0000250|UniProtKB:Q6P4E1};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GOLM family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR860727; CAH92842.1; -; mRNA.
DR   RefSeq; NP_001126659.1; NM_001133187.1.
DR   AlphaFoldDB; Q5R5X4; -.
DR   SMR; Q5R5X4; -.
DR   STRING; 9601.ENSPPYP00000007285; -.
DR   GeneID; 100173659; -.
DR   KEGG; pon:100173659; -.
DR   CTD; 113201; -.
DR   eggNOG; ENOG502QTYH; Eukaryota.
DR   InParanoid; Q5R5X4; -.
DR   OrthoDB; 913812at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026141; CASC4.
DR   InterPro; IPR026139; GOLM1/CASC4.
DR   PANTHER; PTHR15896; PTHR15896; 1.
DR   PANTHER; PTHR15896:SF11; PTHR15896:SF11; 1.
DR   PRINTS; PR02084; GOLM1CASC4.
PE   2: Evidence at transcript level;
KW   Acetylation; Coiled coil; Membrane; Phosphoprotein; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..436
FT                   /note="Protein GOLM2"
FT                   /id="PRO_0000291845"
FT   TOPO_DOM        1..14
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..436
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          193..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          35..195
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        222..245
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        276..339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..400
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..421
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
FT   MOD_RES         233
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
FT   MOD_RES         275
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
FT   MOD_RES         328
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
FT   MOD_RES         332
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
FT   MOD_RES         366
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P4E1"
SQ   SEQUENCE   436 AA;  49417 MW;  5160C98996AC6A03 CRC64;
     MVGFGANRRA GRLPSLVLVV LLVVIVVLAF NYWSISSRHV LLQEEVAELQ GQVQRTEVAR
     GRLEKRNSGL LLLVDTHKKQ IDQKEADYGR LSSRLQAREG LGKRCEDDKV KLQNNISYQM
     ADIHHLKEQL AELRQEFLRQ EDQLQDYRKN NTYLVKRLEY ESFQCGQQIK ELRAQHEENI
     KKLADQFLQE QKQEAHKIQS NDGKELDIND QVVPKNIPKV AENVADKNEE PSSNHIPHGK
     EQIKRGGDAG MPGIEENDLA KVDDLPPALR KPPISVSQHE SHQTISHIPT GQPLSPNMPP
     DSHVNHNGNP GTSKQNPSSP LQRLIPGSNL DSEPRIQTDI LKQATKDRVS DFHKLKQSRF
     FDENESPVDP QHGSKLADYN GDDGNVGEYE ADKQAELAYN EEEDGDGGEE DVQDDEEREL
     QMDPADYGKQ HFNDVL