ID   GOLM2_XENLA             Reviewed;         385 AA.
AC   Q32N32; Q7T0X8;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Protein GOLM2 {ECO:0000305};
DE   AltName: Full=Cancer susceptibility candidate gene 4 protein homolog;
DE            Short=CASC4;
DE   AltName: Full=Golgi membrane protein 2 {ECO:0000305};
GN   Name=golm2; Synonyms=casc4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Embryo, and Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q32N32-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q32N32-2; Sequence=VSP_026266;
CC   -!- SIMILARITY: Belongs to the GOLM family. {ECO:0000305}.
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DR   EMBL; BC055994; AAH55994.1; -; mRNA.
DR   EMBL; BC108864; AAI08865.1; -; mRNA.
DR   RefSeq; NP_001079843.1; NM_001086374.1. [Q32N32-1]
DR   RefSeq; XP_018106143.1; XM_018250654.1.
DR   AlphaFoldDB; Q32N32; -.
DR   SMR; Q32N32; -.
DR   DNASU; 379533; -.
DR   GeneID; 379533; -.
DR   KEGG; xla:379533; -.
DR   CTD; 379533; -.
DR   Xenbase; XB-GENE-6255485; golm2.L.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 379533; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026141; CASC4.
DR   InterPro; IPR026139; GOLM1/CASC4.
DR   PANTHER; PTHR15896; PTHR15896; 1.
DR   PANTHER; PTHR15896:SF7; PTHR15896:SF7; 1.
DR   PRINTS; PR02084; GOLM1CASC4.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Membrane; Reference proteome;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..385
FT                   /note="Protein GOLM2"
FT                   /id="PRO_0000291847"
FT   TOPO_DOM        1..12
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        13..33
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..385
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          169..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          44..193
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        169..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..303
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        323..337
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..385
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         335..363
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_026266"
FT   CONFLICT        114
FT                   /note="N -> T (in Ref. 1; AAH55994)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        181
FT                   /note="T -> S (in Ref. 1; AAH55994)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        334
FT                   /note="S -> K (in Ref. 1; AAH55994)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   385 AA;  43974 MW;  20DFD1255964ED7D CRC64;
     MVGFGAPRRT GRLPPFVLVA LLAVIGLLAF NYWSVSARQA ALHDELLGLQ AQVQRTEVAR
     SRLEKRNSEL MMQSDSHRRQ IEQKQGEYQG LGERLQARDI QAQRCELDKS KLQNNVSLQM
     ADISHLKEQL AELRHEFLRQ EDQLHEYKNN NTFLQKSLQE ESQQCAQQLA ERKREYEENL
     TKQKEELDKQ PQKDEEEGGT VDNKMHILPS EVKEKIEDPS SNRLPFAQDG IKLESDAGMP
     EIEDNEPAKE DSLQNDVKGQ DTGALPSQSK SLLEKQPSLQ PLSFTEHEVK KPLPDKKETV
     QIPEVEENAL QLEPHPLKQM PRDSKTMSFN LKQSRFFDEN ESPVDPQHGS KVADYNGDDG
     NVEDDDHDGQ ADAGEYHKDH LNETL