GON1_CHICK
ID GON1_CHICK Reviewed; 92 AA.
AC P37042; P20407;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH-I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=GnRH-associated peptide 1;
DE AltName: Full=GnRH-associated peptide I;
DE Flags: Precursor;
GN Name=GNRH1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=White leghorn;
RX PubMed=7902095; DOI=10.1677/jme.0.0110019;
RA Dunn I.C., Chen Y., Hook C., Sharp P.J., Sang H.M.;
RT "Characterization of the chicken preprogonadotrophin-releasing hormone-I
RT gene.";
RL J. Mol. Endocrinol. 11:19-29(1993).
RN [2]
RP PROTEIN SEQUENCE OF 24-33, PYROGLUTAMATE FORMATION AT GLN-24, AND AMIDATION
RP AT GLY-33.
RC TISSUE=Hypothalamus;
RX PubMed=7050119; DOI=10.1016/s0021-9258(18)33883-3;
RA King J.A., Millar R.P.;
RT "Structure of chicken hypothalamic luteinizing hormone-releasing hormone.
RT II. Isolation and characterization.";
RL J. Biol. Chem. 257:10729-10732(1982).
RN [3]
RP PROTEIN SEQUENCE OF 24-33.
RC TISSUE=Hypothalamus;
RA King J.A., Millar R.P.;
RT "Structure of avian hypothalamic gonadotrophin-releasing hormone.";
RL S. Afr. J. Sci. 78:124-125(1982).
RN [4]
RP SYNTHESIS OF 24-33.
RX PubMed=7050118; DOI=10.1016/s0021-9258(18)33882-1;
RA King J.A., Millar R.P.;
RT "Structure of chicken hypothalamic luteinizing hormone-releasing hormone.
RT I. Structural determination on partially purified material.";
RL J. Biol. Chem. 257:10722-10728(1982).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; X69491; CAA49246.1; -; Genomic_DNA.
DR PIR; I50644; I50644.
DR RefSeq; NP_001074346.1; NM_001080877.1.
DR AlphaFoldDB; P37042; -.
DR STRING; 9031.ENSGALP00000000365; -.
DR PaxDb; P37042; -.
DR Ensembl; ENSGALT00000000366; ENSGALP00000000365; ENSGALG00000000277.
DR GeneID; 770134; -.
DR KEGG; gga:770134; -.
DR CTD; 2796; -.
DR VEuPathDB; HostDB:geneid_770134; -.
DR eggNOG; ENOG502S8C8; Eukaryota.
DR GeneTree; ENSGT00390000008225; -.
DR HOGENOM; CLU_2412553_0_0_1; -.
DR InParanoid; P37042; -.
DR OMA; ISSGQHW; -.
DR OrthoDB; 1556205at2759; -.
DR PhylomeDB; P37042; -.
DR TreeFam; TF330934; -.
DR Reactome; R-GGA-375281; Hormone ligand-binding receptors.
DR Reactome; R-GGA-416476; G alpha (q) signalling events.
DR PRO; PR:P37042; -.
DR Proteomes; UP000000539; Chromosome 22.
DR Bgee; ENSGALG00000000277; Expressed in granulocyte and 10 other tissues.
DR ExpressionAtlas; P37042; baseline.
DR GO; GO:0030424; C:axon; IDA:AgBase.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0043204; C:perikaryon; IDA:AgBase.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; IDA:UniProtKB.
DR GO; GO:0031530; F:gonadotropin-releasing hormone receptor binding; IDA:Roslin.
DR GO; GO:0032275; P:luteinizing hormone secretion; IMP:AgBase.
DR GO; GO:0033686; P:positive regulation of luteinizing hormone secretion; IDA:AgBase.
DR GO; GO:0046885; P:regulation of hormone biosynthetic process; TAS:AgBase.
DR GO; GO:2000843; P:regulation of testosterone secretion; IMP:AgBase.
DR GO; GO:0000003; P:reproduction; IMP:Roslin.
DR GO; GO:0043279; P:response to alkaloid; IDA:AgBase.
DR GO; GO:1904014; P:response to serotonin; IDA:AgBase.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR InterPro; IPR004079; Gonadoliberin_I_precursor.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR PRINTS; PR01541; GONADOLIBRNI.
DR PROSITE; PS00473; GNRH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:7050119, ECO:0000269|Ref.3"
FT CHAIN 24..92
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012419"
FT PEPTIDE 24..33
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012420"
FT PEPTIDE 37..92
FT /note="GnRH-associated peptide 1"
FT /id="PRO_0000012421"
FT MOD_RES 24
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:7050119"
FT MOD_RES 33
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:7050119"
SQ SEQUENCE 92 AA; 10206 MW; 61AEB7EBAF508B6A CRC64;
MEKSRKILVG VLLFTASVAI CLAQHWSYGL QPGGKRNAEN LVESFQEIAN EMESLGEGQK
AECPGSYQHP RLSDLKETMA SLIEGEARRK EI
