ID   GON1_CLAGA              Reviewed;          80 AA.
AC   P33439;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Progonadoliberin-1;
DE   AltName: Full=Progonadoliberin I;
DE   Contains:
DE     RecName: Full=Gonadoliberin-1;
DE     AltName: Full=Gonadoliberin I;
DE     AltName: Full=Gonadotropin-releasing hormone I;
DE              Short=GnRH-I;
DE     AltName: Full=Luliberin I;
DE     AltName: Full=Luteinizing hormone-releasing hormone I;
DE              Short=LH-RH I;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 1;
DE     AltName: Full=GnRH-associated peptide I;
DE   Flags: Precursor;
GN   Name=gnrh1;
OS   Clarias gariepinus (North African catfish) (Silurus gariepinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Clariidae; Clarias.
OX   NCBI_TaxID=13013;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8020492; DOI=10.1111/j.1432-1033.1994.tb18896.x;
RA   Bogerd J., Zandbergen T., Andersson E., Goos H.;
RT   "Isolation, characterization and expression of cDNAs encoding the catfish-
RT   type and chicken-II-type gonadotropin-releasing-hormone precursors in the
RT   African catfish.";
RL   Eur. J. Biochem. 222:541-549(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 22-31, PYROGLUTAMATE FORMATION AT GLN-22, AND AMIDATION
RP   AT GLY-31.
RC   TISSUE=Brain;
RX   PubMed=1520292; DOI=10.1016/s0006-291x(05)81468-8;
RA   Bogerd J., Li K.W., Janssen-Dommerholt C., Goos H.;
RT   "Two gonadotropin-releasing hormones from African catfish (Clarias
RT   gariepinus).";
RL   Biochem. Biophys. Res. Commun. 187:127-134(1992).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR   EMBL; X78048; CAA54970.1; -; mRNA.
DR   EMBL; X78049; CAA54971.1; -; mRNA.
DR   PIR; S45602; RHID1S.
DR   AlphaFoldDB; P33439; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR002012; GnRH.
DR   Pfam; PF00446; GnRH; 1.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..80
FT                   /note="Progonadoliberin-1"
FT                   /id="PRO_0000012426"
FT   PEPTIDE         22..31
FT                   /note="Gonadoliberin-1"
FT                   /evidence="ECO:0000269|PubMed:1520292"
FT                   /id="PRO_0000012427"
FT   PEPTIDE         35..80
FT                   /note="GnRH-associated peptide 1"
FT                   /id="PRO_0000012428"
FT   MOD_RES         22
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:1520292"
FT   MOD_RES         31
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:1520292"
FT   VARIANT         47
FT                   /note="S -> R"
FT   VARIANT         60
FT                   /note="G -> R"
SQ   SEQUENCE   80 AA;  8893 MW;  0BE5EEE0F4FF861A CRC64;
     MGIKRALWWM VVCVVVLQVS AQHWSHGLNP GGKRAVMQES AEEIPRSSGY LCDYVAVSPG
     NKPFRLKDLL TPVAGREIEE