GON1_HAPBU
ID GON1_HAPBU Reviewed; 94 AA.
AC P51918; O93387;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Progonadoliberin-1;
DE AltName: Full=Progonadoliberin I;
DE Contains:
DE RecName: Full=Gonadoliberin-1;
DE AltName: Full=Gonadoliberin I;
DE AltName: Full=Gonadotropin-releasing hormone I;
DE Short=GnRH-I;
DE AltName: Full=Luliberin I;
DE AltName: Full=Luteinizing hormone-releasing hormone I;
DE Short=LH-RH I;
DE Contains:
DE RecName: Full=GnRH-associated peptide 1;
DE AltName: Full=GnRH-associated peptide I;
DE Flags: Precursor;
GN Name=gnrh1;
OS Haplochromis burtoni (Burton's mouthbrooder) (Chromis burtoni).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Haplochromini; Haplochromis.
OX NCBI_TaxID=8153;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7667296; DOI=10.1073/pnas.92.18.8363;
RA White S.A., Kasten T.L., Bond C.T., Adelman J.P., Fernald R.D.;
RT "Three gonadotropin-releasing hormone genes in one organism suggest novel
RT roles for an ancient peptide.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:8363-8367(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9843638; DOI=10.1006/gcen.1998.7142;
RA White R.B., Fernald R.D.;
RT "Ontogeny of gonadotropin-releasing hormone (GnRH) gene expression reveals
RT a distinct origin for GnRH-containing neurons in the midbrain.";
RL Gen. Comp. Endocrinol. 112:322-329(1998).
RN [3]
RP PROTEIN SEQUENCE OF 23-32, PYROGLUTAMATE FORMATION AT GLN-23, AMIDATION AT
RP GLY-32, AND MASS SPECTROMETRY.
RC TISSUE=Pituitary;
RX PubMed=7644702; DOI=10.1016/0167-0115(95)00014-3;
RA Powell J.F.F., Fischer W.H., Park M., Craig A.G., Rivier J.E., White S.A.,
RA Francis R.C., Fernald R.D., Licht P., Warby C., Sherwood N.M.;
RT "Primary structure of solitary form of gonadotropin-releasing hormone
RT (GnRH) in cichlid pituitary; three forms of GnRH in brain of cichlid and
RT pumpkinseed fish.";
RL Regul. Pept. 57:43-53(1995).
CC -!- FUNCTION: Stimulates the secretion of gonadotropins. May be responsible
CC for the regulation of the hypothalamic-pituitary-gonadal axis.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Synthesized in preoptic neurons and is transported
CC to the pituitary in the preoptic-hypophyseal axons.
CC -!- MASS SPECTROMETRY: [Gonadoliberin-1]: Mass=1113.9; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:7644702};
CC -!- SIMILARITY: Belongs to the GnRH family. {ECO:0000305}.
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DR EMBL; U31865; AAC59691.1; -; mRNA.
DR EMBL; AF076961; AAC27716.1; -; Genomic_DNA.
DR PIR; I50739; I50739.
DR RefSeq; NP_001273225.1; NM_001286296.1.
DR AlphaFoldDB; P51918; -.
DR STRING; 8153.XP_005927046.1; -.
DR GeneID; 102291227; -.
DR CTD; 2796; -.
DR OrthoDB; 1556205at2759; -.
DR Proteomes; UP000264840; Whole Genome Shotgun Assembly.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0005183; F:gonadotropin hormone-releasing hormone activity; NAS:UniProtKB.
DR InterPro; IPR002012; GnRH.
DR InterPro; IPR019792; Gonadoliberin.
DR InterPro; IPR004079; Gonadoliberin_I_precursor.
DR PANTHER; PTHR10522; PTHR10522; 1.
DR Pfam; PF00446; GnRH; 1.
DR PRINTS; PR01541; GONADOLIBRNI.
DR PROSITE; PS00473; GNRH; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Hormone; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:7644702"
FT CHAIN 23..94
FT /note="Progonadoliberin-1"
FT /id="PRO_0000012432"
FT PEPTIDE 23..32
FT /note="Gonadoliberin-1"
FT /id="PRO_0000012433"
FT PEPTIDE 36..94
FT /note="GnRH-associated peptide 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000012434"
FT MOD_RES 23
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:7644702"
FT MOD_RES 32
FT /note="Glycine amide"
FT /evidence="ECO:0000269|PubMed:7644702"
FT CONFLICT 86..94
FT /note="ENGHRTFKK -> KMDTGHSRNERFL (in Ref. 1; AAC59691)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 94 AA; 10382 MW; E57DBA83333278D7 CRC64;
MAAKILALWL LLAGTVFPQG CCQHWSYGLS PGGKRDLDNF SDTLGNMVEE FPRVEAPCSV
FGCAEESPFA KMYRVKGLLA SVAERENGHR TFKK
